The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Herman N. Eisen (1918-2014)

Herman N. Eisen

Professor Emeritus

M.D. 1943, New York University


KI Research Areas of Focus:
Cancer Immunology

The KI community mourns the loss of Herman Eisen, a professor emeritus of biology and founding member of the MIT Center for Cancer Research, who died Nov. 2, 2014, at age 96. Over a 70-year career, Eisen forged a path as a pioneering immunologist whose research has significantly shaped the field. He joined the MIT faculty in 1973, having been recruited by Salvador Luria. Eisen retired from MIT in 1989, albeit only in the official sense: As a professor emeritus, he maintained an active laboratory and continued to research, publish, and advise students and postdocs until his passing. Read obituary

Further Information

Selected Publications

Promiscuous binding of extracellular peptides to cell surface class I MHC protein. Eisen HN, Hou XH, Shen C, Wang K, Tanguturi VK, Smith C, Kozyrytska K, Nambiar L, McKinley CA, Chen J, Cohen RJ. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4580-5.

Evolving concepts of specificity in immune reactions. Eisen HN, Chakraborty AK. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22373-80.

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, Chen J. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2718-23.

Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. Tsomides TJ, Aldovini A, Johnson RP, Walker BD, Young RA, Eisen HN. J Exp Med. 1994 Oct 1;180(4):1283-93.

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein. Udaka K, Tsomides TJ, Eisen HN. Cell. 1992 Jun 12;69(6):989-98.

A novel serine esterase expressed by cytotoxic T lymphocytes. Pasternack MS, Eisen HN. Nature. 1985 Apr 25-May 1;314(6013):743-5.

Myeloma proteins as tumor-specific transplantation antigens. Lynch RG, Graff RJ, Sirisinha S, Simms ES, Eisen HN. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1540-4.

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