The Koch Institute for Integrative Cancer Research at MIT

Probing Enzyme Activity with Nanosensors

Using MIT ingenuity to create knowledge, tools, and treatments to fight cancer

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MIT News

Manalis Lab researchers have discovered that before cells divide, they take out the molecular trash. In a study appearing in eLife and funded by the MIT Center for Precision Cancer Medicine, the team detected a drop in the dry mass of cancer cells using a technique deploying the Manalis Lab’s signature suspended microchannel resonator. Further experimentation revealed an uptick in lysosomal exocytosis, a process where lysosomes—cell organelles that process cellular waste—jettison their contents. Because exocytosis plays a role in the development of resistance to some chemotherapies, the findings could inform new strategies for making cancer cells more susceptible to treatment.