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Black and white photo of a bearded man in very 70s apparel standing in front of a banner with "David Baltimore" and the mirror image text'

Remembering David Baltimore

MIT Koch Institute

With sadness, the Koch Institute marks the passing of Professor David Baltimore. A founding faculty member and formative influence behind the MIT Center for Cancer Research, he was not only a ground-breaking researcher but also a compelling and thoughtful voice for science. 

His discovery of reverse transcriptase changed the prevailing scientific dogma, earned him a 1975 Nobel Prize, and directly enables work in life sciences and biomedical laboratories everywhere. His decades-long advocacy work impacted national policy debates on topics such as recombinant DNA research, the AIDS epidemic, and genome editing.

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Leading the Way for Science and Technology

MIT News

President Joe Biden has named Paula Hammond to the President’s Council of Advisors on Science and Technology. Co-chaired by MIT’s own Eric Lander and Maria Zuber, PCAST is an external advisory board providing the White House with information and policy recommendations on matters involving science, technology, education, and innovation. Hammond, a chemical engineer working in nanotechnology, brings deep expertise in solving human health and global energy challenges, as well as dedication to improving equity and representation in STEM and public health. As director Matt Vander Heiden noted in an email to the KI community, this is an incredible honor, deserving of both gratitude and congratulations. Cheers, Paula!

Cultivating a Love of Science

MIT Biology

Affection for school may not have been in Courtney JnBaptiste’s DNA growing up on a St. Lucia farm, but this KI alum found his MIT home studying microRNAs in Phil Sharp’s lab—first as a high school student and then as a graduate student. Today, he is a patent agent, helping to transform laboratory discoveries into therapeutic practices. 

The Ins and Outs of Metastasis

MIT News

The Manalis Lab, in collaboration with the Jacks Lab, uses a novel cell-counting device to measure the frequency at which tumors shed circulating tumor cells into the bloodstream and how long these CTCs remain in circulation before being cleared by the body. The team's findings, published in Nature Communications, offer a detailed view into the dynamics of metastasis and lay the groundwork for analyzing drug response in real time. This work was supported in part by the Ludwig Center at MIT.

Forest vs. Fires

MIT News

Signaling expert Forest White has begun applying his signature analytical techniques to investigate how environmental factors affect cancer development and progression. A recent modeling study challenges current thinking about carcinogenic compounds called polycyclic aromatic hydrocarbons (PAHs), which are released whenever organic matter is burned, including in wildfires, driving, and cooking. The MIT team’s findings, published in GeoHealth, suggest that the PAH historically used to inform regulatory standards may be inadequate for assessing global cancer risk.

Congratulations, Sachin!

MIT News

Cheers to graduate student Sachin Bhagchandani, the first at MIT to win the National Cancer Institute Predoctoral to Postdoctoral Fellow Transition Award (F99/K00)! Collaborating with the Johnson, Irvine, Langer, and Spranger Labs, Bhagchandani combines immunology and polymer chemistry to develop a drug delivery system that makes certain kinds of cancer immunotherapies less toxic.

Diet, Cancer, and the Microbiome

Cell Stem Cell

Over the years, researchers in the laboratory of Ömer Yilmaz have uncovered important clues into the connections between diet and cancer, with recent work focusing on the role of intestinal stem cells on tumor initiation under various dietary conditions. In a study published in Cell Stem Cell, the lab examines the impact of high fat diets on gut microbes and their interactions with both stem cells and immune cells. The findings suggest that such perturbations to the microbiome significantly dampen immune recognition of premalignant intestinal stem cells, leading to increased tumorigenesis.

Copy That

MIT News

Griffith Lab researchers have developed a new way to grow tiny replicas of the pancreas. These “organoids,” described in Nature Materials, can be grown from healthy or cancerous cells and could help researchers develop and test potential drugs for pancreatic cancer—one of the most difficult types of cancer to treat.

Lees Named Associate Dean

MIT News

KI associate director and Virginia & D.K. Ludwig Professor for Cancer Research Jacqueline Lees has been appointed associate dean in the MIT School of Science. Lees, along with John W. Jarve (1978) Professor in Brain and Cognitive Sciences Rebecca Saxe, will contribute to the school's diversity, equity, and inclusion activities, as well as develop and implement mentoring and other career-development programs to support the community. This work is well aligned with Lees' longstanding leadership at both the Koch Institute and MIT's Department of Biology, and her ongoing commitment to making discovery science research accessible to all.

MIRA MIRA on the Cell

MIT News

Congratulations to chemical engineer Katie Galloway on receipt of the Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health’s National Institute of General Medical Sciences. This prestigious award will support Galloway’s molecular systems biology work to develop multi-scale tools and approaches for understanding and engineering cell-fate transitions in development, reprogramming, and cancer. 

Fighting Health Disparities with Nanomedicine

MIT Koch Institute

Congratulations to Institute Professor and KI member Paula Hammond, the inaugural recipient of the Black in Cancer Distinguished Investigator Award. Established through a partnership between Black in Cancer and the Emerald Foundation in response to racial abuse experienced by Black birdwatcher Chris Cooper in Central Park last year, this award recognizes Black excellence in cancer research and medicine. With this support, Hammond will apply her signature layer-by-layer technology—variations on which were recently featured in National Geographic and The Wall Street Journalto engineer a nanoscale delivery system that direct a combination of chemotherapy and immunotherapy to ovarian cancer cells and the surrounding tumor microenvironment. Although the incidence rate of high grade serous ovarian cancer (HGSOC) is higher in white than black women, the mortality rate is higher for black women, making Hammond's approach a powerful tool for combating serious health disparities.