The 13th Annual Koch Institute Summer Symposium, “RNA Biology, Cancer and Therapeutic Implications,” took place on Friday, June 13, 2014 at Kresge Auditorium on the MIT campus in Cambridge, Massachusetts. The symposium focused on the molecular and cellular mechanisms underlying RNA-based gene regulation in cancer. More than 1,000 cancer researchers, RNA biologists, and clinical oncologists convened to hear updates on the latest breakthroughs in the creation of RNA-based gene-editing tools and the development and intracellular delivery of RNA-cancer medicines.
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IntroductionTyler Jacks, PhD |
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Why RNA BiologyPhillip Sharp, PhD |
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MicroRNAs, Poly(A) Tails and Post-transcriptional Gene RegulationDavid Bartel, PhD |
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Novel microRNA Functions in Mammalian Physiology and CancerJoshua Mendell, MD, PhD
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Targeting siRNA Delivery to TumorsSangeeta Bhatia, MD, PhD |
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Intracellular RNA DeliveryDaniel Anderson, PhD |
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Progress in Advancement of RNAi TherapeuticsJohn Maraganore, PhD
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The Human RNase H1 Degradasome, Biological Roles and Roles in Antisense PharmacologyStan Crooke, MD, PhD |
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The Biology of CRISPRs: From Genome Defense to Genetic EngineeringJennifer Doudna, PhD |
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Regulatory Interactions Between RNA and Polycomb Repressive Complex 2Jeannie Lee, MD, PhD |
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Long Non-coding RNAs: Molecular Regulators of Cell FateLaurie Boyer, PhD |
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Tumor Suppressor and Tumor Maintenance GenesScott Lowe, PhD View video (with closing remarks from Tyler Jacks) |
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Biogen Idec Foundation
Isis Pharmaceuticals
Janssen R&D LLC
Moderna Therapeutics
Onkaido Therapeutics
Thermo Fisher Scientific Inc.
Agilent Technologies, Inc.
Alnylam Pharmaceuticals Inc
Biosearch Technologies
Sanofi
Sarepta Therapeutics
Aveo Oncology Inc.
Cell Signaling Technology, Inc.
CureVac GmbH
Merrimack Pharmaceuticals, Inc.
Mirrx Therapeutics A/S
New England Biolabs
Novartis
RaNA Therapeutics
This activity is supported by an educational donation provided by Amgen.
Beckman Coulter
Biomedical Tech
Cell Signaling Technology
EMD Millipore
Intellicyt
Labcyte
New England Biolabs
Precision Biosystems
Qiagen
Simport
Taconic