Summer Symposium 2014

RNA Biology, Cancer and Therapeutic Implications

The 13th Annual Koch Institute Summer Symposium, “RNA Biology, Cancer and Therapeutic Implications,” took place on Friday, June 13, 2014 at Kresge Auditorium on the MIT campus in Cambridge, Massachusetts. The symposium focused on the molecular and cellular mechanisms underlying RNA-based gene regulation in cancer. More than 1,000 cancer researchers, RNA biologists, and clinical oncologists convened to hear updates on the latest breakthroughs in the creation of RNA-based gene-editing tools and the development and intracellular delivery of RNA-cancer medicines.

NOTE: On November 3, 2015, MIT TechTV suffered a loss of all video data, affecting the videos below. The KI web team is currently in conversation with MIT's Office of Digital Learning to determine whether or not this content can be recovered. Due to ODL's limited back ups and the high volume of recovery requests, we do not anticipate a speedy resolution to this situation. Apologies for the inconvenience and thank you for your patience.

Speakers and Presentations

	Introduction Tyler Jacks, PhD Director, Koch Institute for Integrative Cancer Research David H. Koch Professor of Biology, Massachusetts Institute of Technology Investigator, Howard Hughes Medical Institute View video
	Why RNA Biology Phillip Sharp, PhD Institute Professor, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology View video
	MicroRNAs, Poly(A) Tails and Post-transcriptional Gene Regulation David Bartel, PhD Member, Whitehead Institute Professor of Biology, Massachusetts Institute of Technology Investigator, Howard Hughes Medical Institute View video
	Novel microRNA Functions in Mammalian Physiology and Cancer Joshua Mendell, MD, PhD Professor of Molecular Biology, UT Southwestern Medical Center View video
	Targeting siRNA Delivery to Tumors Sangeeta Bhatia, MD, PhD John J. and Dorothy Wilson Professor of Health Sciences and Technology & Electrical Engineering and Computer Science, Massachusetts Institute of Technology Director, Laboratory for Multiscale Regenerative Technologies, Koch Institute for Integrative Cancer Research Investigator, Howard Hughes Medical Institute View video
	Intracellular RNA Delivery Daniel Anderson, PhD Samuel A. Goldblith Professor of Applied Biology and Associate Professor, Chemical Engineering and Institute for Medical Engineering and Science, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology View video
	Progress in Advancement of RNAi Therapeutics John Maraganore, PhD CEO and Director, Alnylam Pharmaceuticals View video
	The Human RNase H1 Degradasome, Biological Roles and Roles in Antisense Pharmacology Stan Crooke, MD, PhD Chairman of the Board and Chief Executive Officer, Isis Pharmaceuticals, Inc. View video
	The Biology of CRISPRs: From Genome Defense to Genetic Engineering Jennifer Doudna, PhD Professor of Molecular and Cell Biology and Chemistry, University of California, Berkeley Investigator, Howard Hughes Medical Institute View video
	Regulatory Interactions Between RNA and Polycomb Repressive Complex 2 Jeannie Lee, MD, PhD Professor of Genetics (and Pathology), Massachusetts General Hospital Investigator, Howard Hughes Medical Institute View video
	Long Non-coding RNAs: Molecular Regulators of Cell Fate Laurie Boyer, PhD Irwin and Helen Sizer Career Development Associate Professor of Biology, Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research View video
	Tumor Suppressor and Tumor Maintenance Genes Scott Lowe, PhD Associate Director for Basic Cancer Research, Cancer Biology and Genetics Program; Chair, Geoffrey Beene Cancer Research Center, Memorial Sloan-Kettering Cancer Center Investigator, Howard Hughes Medical Institute View video  (with closing remarks from Tyler Jacks)

We gratefully acknowledge our

Partners                                  

Biogen Idec Foundation

Affiliates                                    

Isis Pharmaceuticals
Janssen R&D LLC
Moderna Therapeutics
Onkaido Therapeutics
Thermo Fisher Scientific Inc.  

Collaborators                        

Agilent Technologies, Inc.
Alnylam Pharmaceuticals Inc
Biosearch Technologies
Sanofi
Sarepta Therapeutics

Sponsors                      

Aveo Oncology Inc.
Cell Signaling Technology, Inc.
CureVac GmbH
Merrimack Pharmaceuticals, Inc.
Mirrx Therapeutics A/S
New England Biolabs
Novartis
RaNA Therapeutics

Grant Support

This activity is supported by an educational donation provided by Amgen.

Vendors

Beckman Coulter
Biomedical Tech
Cell Signaling Technology
EMD Millipore
Intellicyt
Labcyte
New England Biolabs 
Precision Biosystems
Qiagen
Simport  
Taconic