The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Immune Engineering Symposium 2019

January 28-29, 2019
Kresge Auditorium, MIT

Biological, chemical, and materials engineers are engaged at the forefront of immunology research. At their disposal is an analytical toolkit honed to solve problems in the petrochemical and materials industries, which share the presence of complex reaction networks, and convective and diffusive molecular transport. Powerful synthetic capabilities have also been crafted: binding proteins can be engineered with effectively arbitrary specificity and affinity, and multifunctional nanoparticles and gels have been designed to interact in highly specific fashions with cells and tissues. Fearless pursuit of knowledge and solutions across disciplinary boundaries characterizes this nascent discipline of immune engineering, synergizing with immunologists and clinicians to put immunotherapy into practice.

The 2019 symposium will include two poster sessions and four abstract-selected talks. Abstracts should be uploaded on the registration page

Schedule:

DAY 1: JANUARY 28, 2019

7:00-8:10: Registration

8:10-8:15 Introductory Remarks

8:15-9:40 Session I

Moderator:  Dane Wittrup | Koch Institute | MIT

Robert Schreiber | Bursky Center for Human Immunology and Immunotherapy Programs | Washington University School of Medicine in St. Louis
Neoantigens and the molecular basis of personalized cancer immunotherapy

Tyler Jacks | Koch Institute for Integrative Cancer Research | MIT
Exploring tumor-immune interactions with genetically engineered cancer models

Poster Presenter  
Scott Wilson | University of Chicago

Cathy Wu | Dana-Farber Cancer Institute | Harvard Medical School
Building better personal cancer vaccines

9:40-10:40 Poster Session | Break

10:40-11:55 Session II

Moderator: Tyler Jacks | Koch Institute | MIT

Melody Swartz | University of Chicago
Engineering local lymphangiogenesis for immunomodulation

Darrell Irvine | Koch Institute for Integrative Cancer Research | MIT
Innate immune recognition of glycosylation in nanoparticle vaccines

Stephanie Dougan | Dana-Farber Cancer Institute | Harvard Medical School
Augmenting T cell immunity to poorly immunogenic tumors

12:00-1:30 Lunch Break

1:30-3:20 Session III

Moderator: Darrell Irvine| Koch Institute | MIT

Max Krummel | Bakar ImmunoX Initiative | University of California, San Francisco
Imaging a world beyond checkpoints: Classes of immune systems in vivo

Stefani Spranger | Koch Institute for Integrative Cancer Research | MIT
The role of tumor-resident DC for productive anti-tumor immune responses

Poster Presenter 
Noor Momin | MIT

Mikael Pittet | Harvard Medical School | Massachusetts General Hospital
Myeloid cells in cancer

Michael Dustin | Kennedy Institute of Rheumatology | University of Oxford
Delivery of T cell effector function through extracellular vesicles

3:20-4:00 Poster Session | Break

DAY 2: JANUARY 29, 2019

8:15-9:40 Session IV

Moderator: Michael Birnbaum | Koch Institute | MIT

Jamie Spangler | Johns Hopkins University
Reprogramming anti-cancer immunity through molecular engineering

Bryan Bryson | MIT
Exploiting the macrophage axis in Mycobacterium tuberculosis infection

Poster Presenter 
Preeti Sharma | University of Illinois

Facundo Batista | Ragon Institute of MGH, MIT and Harvard
Vaccine evaluation in rapidly produced custom humanized mouse models

9:40-10:30 Poster Session | Break

10:30-11:45 Session V

Moderator: Dane Wittrup | Koch Institute | MIT

Yvonne Chen | University of California, Los Angeles | Parker Institute for Cancer Immunotherapy, Center at UCLA
Engineering smarter and stronger T cells for cancer immunotherapy

Michael Birnbaum | Koch Institute for Integrative Cancer Research | MIT
A repertoire-scale look at T and NK cell recognition

Glenn Dranoff | Novartis Institutes for BioMedical Research 
Mechanisms of protective tumor immunity

11:45-1:00 Lunch Break

1:00-2:00 Session VI

Moderator: Stefani Spranger | Koch Institute | MIT

Timothy A. Springer | Harvard Medical School | Boston Children's Hospital 
The Milieu Model for TGF-β Activation

Alex Shalek | Institute for Medical Engineering and Science |  Koch Institute for Integrative Cancer Research | MIT
Identifying and rationally modulating cellular drivers of enhanced immunity

Poster Presenter 
Martin LaFleur | Harvard Medical School

2:00-2:45 Poster Session | Break

2:45-3:35 Session VII

Moderator: Stefani Spranger | Koch Institute | MIT

Diane Mathis | Harvard Medical School
Tissue Tregs

Aviv Regev | Broad Institute | MIT
Cell atlases as roadmaps to understand cancer

3:35-4:00 Concluding Remarks