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Linzixuan (Rhoda) Zhang holding the medal she won in the 2024 Collegiate Inventors Competition

Rhoda Zhang Wins 2024 Collegiate Inventors Competition

MIT News

November 5, 2024

Graduate student Linzixuan (Rhoda) Zhang has won the 2024 Collegiate Inventors Competition in both the Graduate and People's Choice categories. With advisors Robert Langer and Ana Jaklenec, Zhang and KI postdoc Xin Yang are developing metal-organic frameworks and other safe, sustainable nutrient stabilizing materials to address global micronutrient deficiencies. They are also launching MOFe™ Coffee, the first iron-fortified coffee.

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Converging on Cancer on the Nanoscale

MIT News

July 7, 2017

This summer, we mark the first anniversary of the launch of our Marble Center for Cancer Nanomedicine, established through a generous gift from Kathy and Curt Marble ’63. Bringing together leading Koch Institute faculty members and their teams, the Marble Center focuses on grand challenges in cancer detection, treatment, and monitoring that can benefit from the emerging biology and physics of the nanoscale. In its first year, the Center funded six transformative research projects in the areas of drug delivery and immunotherapy, established a scientific advisory board, and provided fellowship support for trainees, along with valuable opportunities for mentorship, scientific exchange, and professional development. We look forward to continued success and progress at the interface of nanotechnology and medicine.

The Life of a Pioneer

MedPage Today

May 23, 2017

Did you know that KI faculty member Robert Weinberg once built a cabin by hand in the woods of New Hampshire? Or that during the Civil Rights movement, he housed sharecroppers in Alabama who had been evicted from their land for registering to vote? Fascinating facts, that we enjoyed learning about in a recent article by MedPage Today. In the article, Weinberg — who is widely regarded as a cancer research pioneer for his discoveries of the first human oncogene, and the first tumor suppressor gene — talks about successes and setbacks over the course of his career, reflects on his tenure at MIT as a student, member of MIT's Center for Cancer Research (predecessor to the Koch Institute), and founding member of the Whitehead Institute.

The Cool Nano-nerds

WBUR

May 15, 2017

The KI dream team of Sangeeta Bhatia, Angela Belcher, and Paula Hammond are (as they describe themselves) "the cool kind of nerds" who are making substantial advances in cancer research on the nanoscale. Comprising half of the all-star faculty at the KI's Marble Center for Cancer Nanomedicine (of which Bhatia is the director), this power trio combines their expertise in various scientific areas and engineering disciplines to develop a theranostic platform — a combination diagnostic and therapy — made from nanomaterials to detect tumors at their earliest stages and destroy them before they become threatening. In the latest "This Moment in Cancer" segment from WBUR, these three dedicated engineers talk about the potential of nanomedicine in the fight against cancer and how, as researchers and mentors, they work to inspire the next generation of scientists and engineers. 

Jacks Went Up The Hill

MIT News

April 10, 2017

What do you get when you put three leading cancer researchers and a passionate advocate in front of the House Committee on Oversight and Government Reform? Support for cancer research on both sides of the aisle. On March 29, KI Director Tyler Jacks joined a panel of cancer research experts to testify in front of the bipartisan committee and argue that federal investment in cancer research is critical for the vitality of the nation’s citizens, economy, and status as the global leader in biomedical research. 

Defeating Diagnostic Deficits

MIT News

April 10, 2017

A major challenge in fighting cancer is catching it early, when therapies tend to be most effective and patient outcomes most improved. In a recent Nature Biomedical Engineering publication, the Bhatia Lab shows off the capabilities of the new and improved version of their non-invasive urinary diagnostic, which incorporates new design strategies for tumor-specific signal generation and better penetration into tumors.

Welcome to Langermania

Harvard Business Review

February 28, 2017

KI member Robert Langer, the David H. Koch Institute Professor, has been doing laps around the press circuit, but don't plan on him slowing down anytime soon. Most recently, Langer was featured as "The Edison of Medicine" in Harvard Business Review via an in-depth profile detailing his illustrious accomplishments as an academic and entrepreneur. The article includes business advice from Langer himself — as well as success stories about research by Langer Lab postdocs Oliver "Ollie" Jonas and Mark Tibbitt. The projects described, respectively supported in part by the Koch Institute's Frontier Research Program and S. Leslie Misrock Frontier Research Fund for Cancer Nanotechnology, highlight the culture of the lab itself and the important role that mentorship plays in transforming ideas into impact.

Langer also headlined an article in WIRED showcasing his contributions to smarter drug delivery, namely his work with polymers to create long-lasting pills and drugs. Finally, Langer got personal with the science-based human interest blog Humans of Science as he talked about his career, inspirations, and motivations. (Phew!)

What's Your Damage?

Nature Medicine

February 27, 2017

Are all chemotherapies created equal? Researchers in the laboratories of KI members Michael Hemann and Stephen Lippard analyzed the mechanisms of action of three common platinum-based chemotherapeutics and discovered that drugs that were thought to act similarly actually kill cells in very different ways. Their results, published in Nature Medicine, suggest that our current arsenal of anti-cancer agents are not generic killers, but rather can be targeted towards specific cancer alterations to achieve optimal results.

This work was supported in part by the Koch Institute Frontier Research Program through the Michael (1957) and Inara Erdei Fund and Kathy and Curt Marble Cancer Research Fund, and a Misrock Postdoctoral Fellowship.

Takeda Care of Business

MIT News

February 13, 2017

Takeda Pharmaceuticals has given a generous gift to support groundbreaking research in immuno-oncology at the KI. The gift, aimed to encourage several novel research approaches over the next two years, will allow investigators to advance their understanding of the relationship between the immune system and cancer, and accelerate the development of new immunotherapeutic approaches. Immuno-oncology, prioritized by Takeda as “arguably one of the most impactful recent breakthroughs in cancer research” has been one of the KI’s five core focus areas since its founding.

Can't Wait for the Seq-Well

MIT News

February 13, 2017

Fans of the Love Lab’s signature nanowell technology will be captivated by a new paper in Nature Methods, and by the associated opportunities to rapidly isolate and sequence RNA from complex patient samples. Working with researchers in MIT’s Department of Chemistry, KI engineers have developed an accessible, portable platform for sequencing RNA from many cells simultaneously, which allows the researchers to identify and analyze different cell types found in individual blood or tissue samples, and look for patterns in their gene expression. With expected applications for multiple diseases, including cancer, the Seq-Well approach is sure to be a blockbuster, coming soon to laboratories near you. In fact, the line is already out the door for the new Nanowell Cytometry platform in the KI’s Flow Cytometry Core Facility, and the research team has already joined forces with clinical investigators at Dana-Farber/Harvard Cancer Center to apply this technology toward discovery of new combination immunotherapies as part of the collaborative Bridge Project.

Hammond Elected to the National Academy of Engineering

MIT News

February 10, 2017

Congratulations to the Koch Institute's Paula Hammond on her election to the National Academy of Engineering (NAE), one of the highest professional distinctions that can be accorded to an engineer. Hammond, a David H. Koch Professor of Engineering and the Head of the Department of Chemical Engineering, is one of eight faculty members from MIT named to the 2017 NAE Election Class. A polymer chemist, she was selected for her contributions to self-assembly of polyelectrolytes, colloids, and block copolymers at surfaces and interfaces for energy and health care applications.