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Luc7, the blue group of proteins, against a background of human cells.

Splice of life

MIT News

February 20, 2025

The Burge lab has discovered a new type of control over RNA splicing, a process critical for gene expression. Appearing in a new Nature Communications paper, their study sheds light on how this control mechanism can go wrong—and serve as a potential therapeutic target—in acute myelogenous leukemias and other diseases.

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Showing 281–290 of 613 stories

Vote now for KI cancer research in STAT Madness

STAT News

March 3, 2022

KI cancer research needs your support in STAT's annual bracket-style tournament to find the best innovations in science and medicine. Register or sign in to your free STAT account to vote early and often for these three projects: the Jacks Lab's new pancreatic cancer approach in Matchup 5; the Barzilay Lab's AI-enhanced mammography in Matchup 16; and the Langer/Traverso Lab's collaboration with Duke University to improve drug delivery with machine learning and high-throughput design in Matchup 10.

KI Leadership Team Updates

MIT Koch Institute

March 1, 2022

Jackie Lees has stepped aside after more than 20 years as an Associate Director, first at the MIT Center for Cancer Research and then at the Koch Institute. She had an enormous impact in shaping our current organization, as well as the Robert A. Swanson (1969) Biotechnology Center and core facilities. Lees will continue to support the work of MIT and the Koch Institute through her role as Associate Dean in the MIT School of Science. Angela Koehler has been named interim associate director, joining Darrell Irvine in providing administrative oversight of various research and community initiatives.

Two Degrees of Preparation

MIT News

February 27, 2022

Doyle Lab alum Nidhi Juthani is learning the languages of both science and business. Juthani’s doctoral work focused on developing hydrogel microparticles for microRNA and extracellular vesicle detection with the goal of improving tools for researching and diagnosing diseases, including cancer. With her PhD complete, Juthani is now pursuing an MBA at the Sloan School of Management with the goal of launching a career where she can serve as a bridge between scientific research and industry.

Mens, manus, et mentorship

MIT News

February 24, 2022

In addition to his award-winning work to understand and model metastatic colorectal cancer, Jacks Lab undergraduate researcher Daniel Zhang has found numerous ways to create STEM mentorship pipelines within and beyond MIT. He credits MIT’s “mens et manus” philosophy, which encourages the hands-on application of knowledge, as significant to his success.  

STATUS Report

STAT News

February 22, 2022

Cheers to Regina Barzilay and Sangeeta Bhatia on making the 2022 STATUS List! STAT’s list, featuring 46 leaders in health, medicine, and science, highlights Barzilay’s machine learning model to improve risk assessment for breast cancer and Bhatia’s efforts to increase the number of women founders in biotech through the Future Founders Initiative.  

Probing Protein Pairing

MIT News

February 3, 2022

No protein is an island; most rely on partners to carry out their vital functions. A new screening method from the Keating Lab probes more deeply into how proteins recognize and bind to one another. In studies published in eLife last December and January, researchers used information generated by the new method to guide the design of a synthetic molecule that binds ENAH, a protein implicated in cancer metastasis. Their results could inform the future design of cancer drugs, as well as fundamental understandings about cell function and regulation

Interactions of Interest

Morgridge Institute for Research

January 21, 2022

A new paper in Science Advances describes how cancer cells can hijack the metabolic activity of certain non-cancer cells in the pancreas to fuel tumor growth. The study combines a sophisticated 3D organoid model developed by the Vander Heiden Lab with optical imaging from the Morgridge Institute’s Skala Lab to better understand tumor cell proliferation in the context of the tumor microenvironment.

The Right Tempo for Cancer Screening

MIT News

January 21, 2022

Tempo, an AI-based tool developed by Regina Barzilay, tailors breast cancer screening guidelines to a patient’s individual risk. A study of hospital datasets published in Nature Medicine showed that Tempo worked most efficiently when paired with the team’s risk-assessment algorithm Mirai, detecting cancer earlier while recommending fewer screenings overall. The technology’s dynamic framework is designed to make cancer screenings more cost-effective and equitable.

Seq and Ye Shall Find

Broad Institute

January 20, 2022

One major challenge in cancer genetics is figuring out which of the millions of protein-coding mutations drive disease. A report appearing in Nature Biotechnology describes a new method that combines experimental and computational approaches to assess the functions of these genetic alterations. The work builds on sequencing tools developed in the Broad Institute labs of KI members Aviv Regev and Jesse Boehm.

Alum for the Ride

MIT News

January 10, 2022

Irvine and Wittrup lab researchers have developed a technique to make cytokine therapy less toxic. These immunostimulatory molecules are quite potent and can have devastating side effects if administered systemically. In a preclinical study appearing in Nature Biomedical Engineering and supported in part by the Marble Center for Cancer Nanomedicine, the researchers anchored the cytokines to tumors with aluminum hydroxide, a compound that is often used to make vaccines more effective. They then administered immune checkpoint blockade therapy, observing that the tumors were eliminated in 50 to 90 percent of the mice across three cancer types. The technology has been licensed to a startup company that hopes to begin clinical trials by the end of the year.