The Jacks Lab developed new lung organoids for modeling lung adenocarcinoma (LUAD), which comprises approximately 40% of all non-small cell lung cancer cases in the US. Derived from stem cells, organoids are mini cultured organs that provide the ease and speed of use of cell lines, but with improved physiological replication of disease progression. The lab’s approach, described in Genes and Development, provides a gateway to better understanding of LUAD as well as a powerful and flexible strategy for future cancer modeling.