A Nature Biomedical Engineering paper from the Shalek, Langer and Yilmaz Labs demonstrates a breakthrough screening approach for uncovering molecules that control the cellular composition of barrier tissues. Using intestinal organoids, they discovered a tissue-modifying molecule that targets intestinal stem cells and signals the creation of new Paneth cells, a rare but important antimicrobial producing cell that is known to be depleted in several diseases. Their findings could inform understanding of normal tissue function and therapeutic intervention.
Parts of this work have been supported by the MIT Stem Cell Initiative, the Koch Institute Frontier Research Program via the Kathy and Curt Marble Cancer Research Fund, and the Bridge Project.