Congratulations to Michael Birnbaum on receipt of a National Institutes of Health New Innovators Award for his work using peptide-MHC lentivirus display to identify repertoire-scale T cell antigens. Administered through the High Risk, High Reward program, the award celebrates highly innovative and unusually impactful research by extraordinarily creative early career scientists. Birnbaum, who joined the Koch Institute faculty in 2016, uses protein engineering, structural biology, and bioinformatics to understand and manipulate immune-cell recognition and signaling.