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Viktor Adalsteinsson

KI alum Viktor Adalsteinsson develops liquid biopsies to detect cancer

Slice of MIT

March 6, 2024

Cancer patients who undergo surgery are often left with a frightening question: Did the surgeons get all the cancerous cells? No one wants a recurrence of disease, but additional treatments such as radiation or chemotherapy have significant side effects. That’s why Viktor Adalsteinsson PhD ’15 has been developing tools to support better-informed treatment decisions: so-called “liquid biopsies” that can detect the presence of cancer from a simple blood test.

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Showing 11–20 of 537 stories

Early SOX knockout could score cancer win

MIT News

February 28, 2024

The Yilmaz and Jacks labs, with collaborators, have found that early in colon cancer development, cells that activate the SOX17 gene can become essentially invisible to the immune system. Further, blocking SOX17 may offer a new way to treat early-stage cancers before they progress, or aid prevention in patients prone to developing colon polyps.

This work was supported in part by the Bridge Project and the MIT Stem Cell Initiative.

Sharp Lab alum Albert Almada talks stem cells

MIT News

February 21, 2024

“Digging deep into the science is what MIT taught me." Albert Almada PhD ’13 talks about how his time in the Sharp Lab helped prepare him to ask new questions about how stem cells rebuild tissues. 

Machine learning model predicts drugs that shouldn't be taken together

MIT News

February 20, 2024

The Traverso Lab developed a method to identify drugs that should not be taken together. Led by former KI postdocs Yunhua Shi and Daniel Reker, the Nature Biomedical Engineering study used both machine learning and tissue models to predict whether drugs rely on the same transporters to exit the digestive tract.

STING Discoveries garner Michelson Prize

Michelson Medical Research Foundation

February 19, 2024

Irvine Lab alum Bingxu Liu PhD '23 (VII) has been recognized with the 2024 Michelson Philanthropies and Science Prize for Immunology for uncovering how the STING signaling pathway controls a variety of immune responses. In his prize profile he recounts how he became interested in science and, eventually immunology, before focusing on STING in his graduate research at MIT.

Clinical progress for hitchhiking cancer vaccine

MIT News

February 15, 2024

A cancer therapy vaccine shows promising results in Phase 1 clinical trials, provoking surprisingly strong anti-tumor immune responses in pancreatic cancer patients. Using technology originating in the Irvine Lab with support from Bridge Project and refined by Elicio Therapeutics, the vaccine hitches a ride on the protein albumin to the lymph nodes, where large populations of immune cells can be taught to attack cancer cells. The Phase 1 vaccine targeted two variations of the cancer gene KRAS. Elicio is currently testing a vaccine that targets seven KRAS mutants, and plans to address other KRAS-driven cancers, such as colorectal and non-small cell lung cancers.  

New initiative takes aim at women’s cancers

MIT Koch Institute

February 7, 2024

A new women’s cancers research initiative will pursue the ambitious goal of early diagnosis, detection, and interception of ovarian cancer and other intractable tumors. Led by Angela Belcher, Sangeeta Bhatia, and Paula Hammond, the initiative is supported in part by a gift from the Gray Foundation.
 

Bile duct cancer diagnostic wins AMA Grand Challenge

American Medical Association

February 6, 2024

Bhatia Lab alum Jesse Kirkpatrick won first place in the 2023 AMA Research Challenge for work developing a new diagnostic for cholangiocarcinoma—a rare bile duct tumor among the deadliest cancers.

An expansive view of glioma cells

MIT News

January 31, 2024

Using their signature expansion microscopy technique, Boyden Lab researchers have imaged human brain tissue in greater detail than ever before. In a study appearing in Science Translational Medicine and funded in part by the Koch Institute Frontier Research Program via the Kathy and Curt Marble Cancer Research Fund, the team analyzed patient samples of the most aggressive primary brain tumor, high-grade glioblastoma, and low-grade gliomas, which are considered less aggressive. They found that more low grade glioma cells than expected expressed vimentin, a protein that is found in highly aggressive glioblastomas, suggesting that some of these tumors may be more aggressive than previously thought. The researchers hope that this technique could eventually be deployed to diagnose tumors, generate more accurate prognoses, and help doctors choose treatments. 
 

Paula Hammond, 2024 Franklin Institute Awards Laureate

Franklin Institute

January 31, 2024

Congratulations to Paula Hammond, 2024 Franklin Institute Awards Laureate. Now marking the second century since its inception, the award has honored the most influential scientists, engineers, and inventors who have significantly advanced science and technology, including Nikola Tesla, Marie and Pierre Curie, Orville Wright, Thomas Edison, Albert Einstein, Jane Goodall, Stephen Hawking, and more recently, vaccine pioneers Kizzmekia Corbett, Drew Weissman, and Katalin Karikó. Hammond wins the medal in chemistry for her "innovative methods to create novel materials one molecular layer at a time, and for applying these materials to areas ranging from drug delivery to energy storage."

Nancy Hopkins to receive 2024 Public Welfare Medal 

MIT Koch Institute

January 24, 2024

Congratulations to Nancy Hopkins, who will receive the prestigious the National Academy of Sciences Public Welfare Medal for “her courageous leadership over three decades to create and ensure equal opportunity for women in science.”  The medal is the Academy’s most prestigious award, established in 1914 and presented annually to honor extraordinary use of science for the public good.