Turning a toxin into a tool

A team of MIT and Harvard researchers developed a novel method to enhance genome editing precision. In a PNAS study co-led by Ron Raines, Koch Institute member and professor of chemistry at MIT, and Amit Choudhary, professor of medicine at Harvard Medical School, used an anthrax-derived component to deliver anti-CRISPR proteins to effectively reduces off-target Cas9 activity and boost genome-editing specificity up to 40%.