A new Cell Systems paper from the White lab identified mechanisms that enable resistance to cancer therapies, offering new opportunities to intervene for better patient outcomes. Mapping cell-wide signaling networks remodeled by therapy in unprecedented depth, the study reveals new insights into cancer cell plasticity and demonstrates a new drug combination repurposing a leukemia drug against melanoma. This work was supported in part by the MIT Center for Precision Cancer Medicine and a graduate fellowship from the Ludwig Center at MIT.