The Jaklenec Group designed a nanoparticle made from a metal organic framework (MOF) that both delivers vaccines and acts as an adjuvant to generate a strong immune response at a lower dose. In a study of mice appearing in Science Advances, the researchers showed that this MOF could successfully encapsulate and deliver part of the SARS-CoV-2 spike protein, while also acting as an adjuvant once the MOF is broken down inside cells.