The Commonwealth Foundation for Cancer Research has pledged $20 million to the Bridge Project, a collaborative research program of the Koch Institute for Integrative Cancer Research at MIT and the Dana-Farber/Harvard Cancer Center, to accelerate the translation of interdisciplinary cancer solutions toward the clinic. The Commonwealth Foundation gift, which will be made over the next five years, will double the number of grants available to fund these multi-investigator teams each year. It also will create two new funding mechanisms that will extend the pipeline of collaboration and catalyze the translation of basic research toward clinical trials. “Footbridge Grants” will enable new teams to form and establish proof of concept. “Expansion Grants” will provide follow-on funding to existing teams that are on the cusp of making significant advances toward clinical implementation.