The Koch Institute for Integrative Cancer Research at MIT

an accordion of endothelial cells stained in pink and green

Using MIT ingenuity to create knowledge, tools, and treatments to fight cancer

Our Research Areas

From fundamental discoveries to engineering advances, we strategically pursue five areas of research that, across tumor types, are critical for rapid progress toward defeating cancer.

As a National Cancer Institute-designated basic cancer research center, we produce knowledge and tools to fight one of humanity's most persistent challenges.

NCI Cancer Center: A Cancer Center Designated by the National Cancer Institute

News

From Dormant to Dangerous

MIT News

New Weinberg lab research, published in PNAS, reveals how cancer cells reawaken from dormancy. They showed this mechanism is sparked by inflammation in surrounding tissue, then driven by M2 macrophages that secrete EGFR ligands signaling dormant cancer cells to rapidly multiply. Moreover, cells develop ‘awakening memory,’ no longer requiring inflammatory signals to stay active. Understanding these mechanisms could enable more effective strategies against metastatic cancer. This work was supported in part by the MIT Stem Cell Initiative.

At the Koch Institute for Integrative Cancer Research, scientists and engineers work together to solve some of the most difficult problems in cancer. We ask big questions in strategic areas, where the answers have big impacts on how we understand and treat cancer.