Progress: October 2017
1. Advancing therapeutic applications of synthetic gene circuits. Higashikuni Y, Chen WC, Lu TK. Curr Opin Biotechnol. pubmed:28750201; doi:10.1016/j.copbio.2017.06.011
2. Menopausal hormone therapy for primary prevention: why the USPSTF is wrong. Langer RD, Simon JA, Pines A, Lobo RA, Hodis HN, Pickar JH, Archer DF, Sarrel PM, Utian WH. Menopause. pubmed:28872490; doi:10.1097/GME.0000000000000983
3. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS. JCI Insight. pubmed:28978806; doi:10.1172/jci.insight.94298
4. Nonspecificity in a nonimmune human scFv repertoire. Kelly RL, Zhao J, Le D, Wittrup KD. MAbs. pubmed:28910564; doi:10.1080/19420862.2017.1356528
5. Chaperone proteins as single component reagents to assess antibody nonspecificity. Kelly RL, Geoghegan JC, Feldman J, Jain T, Kauke M, Le D, Zhao J, Wittrup KD. MAbs. pubmed:28745541; doi:10.1080/19420862.2017.1356529
6. Tumor-Penetrating Delivery of siRNA against TNFalpha to Human Vestibular Schwannomas. Ren Y, Sagers JE, Landegger LD, Bhatia SN, Stankovic KM. Sci Rep. pubmed:29018206; doi:10.1038/s41598-017-13032-9
7. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. Tzafriri AR, Garcia-Polite F, Zani B, Stanley J, Muraj B, Knutson J, Kohler R, Markham P, Nikanorov A, Edelman ER. J Control Release. pubmed:28867375; doi:10.1016/j.jconrel.2017.08.037
8. Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery. Li J, He Y, Wang W, Wu C, Hong C, Hammond PT. Angew Chem Int Ed Engl. pubmed:28925033; doi:10.1002/anie.201707466
9. Erratum: Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants. Spencer KC, Sy JC, Ramadi KB, Graybiel AM, Langer R, Cima MJ. Sci Rep. pubmed:28993678; doi:10.1038/s41598-017-12312-8
10. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics. Bertrand N, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim JM, Karnik R, Langer R, Farokhzad OC. Nat Commun. pubmed:28974673; doi:10.1038/s41467-017-00600-w
11. Oral delivery of biologics using drug-device combinations. Caffarel-Salvador E, Abramson A, Langer R, Traverso G. Curr Opin Pharmacol. pubmed:28779684; doi:10.1016/j.coph.2017.07.003
12. Antimicrobial Peptides: Role in Human Disease and Potential as Immunotherapies. de la Fuente-Nunez C, Silva ON, Lu TK, Franco OL. Pharmacol Ther. pubmed:28435091; doi:10.1016/j.pharmthera.2017.04.002
13. An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in Escherichia coli. Cleto S, Lu TK. MBio. pubmed:29018120; doi:10.1128/mBio.01474-17
14. Biocompatibility, bone healing, and safety evaluation in rabbits with an IlluminOss bone stabilization system. McSweeney AL, Zani BG, Baird R, Stanley JR, Hayward A, Markham PM, Kopia GA, Edelman ER, Rabiner R. J Orthop Res. pubmed:28135014; doi:10.1002/jor.23532
15. Randomized Comparison of Ridaforolimus-Eluting and Zotarolimus-Eluting Coronary Stents in Patients with Coronary Artery Disease: Primary Results from the BIONICS Trial. Kandzari DE, Smits PC, Love MP, Ben-Yehuda O, Banai S, Robinson SD, Jonas M, Kornowski R, Bagur R, Iniguez A, Danenberg HD, Feldman RL, Jauhar R, Chandna H, Parikh MA, Perlman GY, Balcells M, Markham PM, Ozan MO, Genereux P, Edelman E, Leon MB, Stone GW. Circulation. pubmed:28794001; doi:10.1161/CIRCULATIONAHA.117.028885
16. Roles for Innate Immunity in Combination Immunotherapies. Moynihan KD, Irvine DJ. Cancer Res. pubmed:28928130; doi:10.1158/0008-5472.CAN-17-1340
17. Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity. Chen YC, Farzadfard F, Gharaei N, Chen WCW, Cao J, Lu TK. Mol Cell. pubmed:28985507; doi:10.1016/j.molcel.2017.09.014
18. The Human Cell Atlas: from vision to reality. Rozenblatt-Rosen O, Stubbington MJT, Regev A, Teichmann SA. Nature. pubmed:29072289; doi:10.1038/550451a
19. Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells. Semrau S, Goldmann JE, Soumillon M, Mikkelsen TS, Jaenisch R, van Oudenaarden A. Nat Commun. pubmed:29061959; doi:10.1038/s41467-017-01076-4
20. Human Embryo Editing: Opportunities and Importance of Transnational Cooperation. Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D. Cell Stem Cell. pubmed:28985523; doi:10.1016/j.stem.2017.09.010
21. An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells. Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalova P, Legartova S, Bartova E, Farkash-Amar S, Jaenisch R, Alon U, Meshorer E. Stem Cell Reports. pubmed:28966122; doi:10.1016/j.stemcr.2017.08.022
22. Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation. Edupuganti RR, Harikumar A, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MA, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R, Meshorer E. Stem Cell Reports. pubmed:28966118; doi:10.1016/j.stemcr.2017.08.021
23. Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. Kalan S, Amat R, Schachter MM, Kwiatkowski N, Abraham BJ, Liang Y, Zhang T, Olson CM, Larochelle S, Young RA, Gray NS, Fisher RP. Cell Rep. pubmed:29020632; doi:10.1016/j.celrep.2017.09.056
24. HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models. Neueder A, Gipson TA, Batterton S, Lazell HJ, Farshim PP, Paganetti P, Housman DE, Bates GP. Sci Rep. pubmed:28970536; doi:10.1038/s41598-017-12897-0
25. Landscape of X chromosome inactivation across human tissues. Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A, Cummings BB, Castel SE, Karczewski KJ, Aguet F, Byrnes A, Lappalainen T, Regev A, Ardlie KG, Hacohen N, MacArthur DG. Nature. pubmed:29022598; doi:10.1038/nature24265
26. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH. Cell Rep. pubmed:29020624; doi:10.1016/j.celrep.2017.09.039
27. Single-cell transcriptomics to explore the immune system in health and disease. Stubbington MJT, Rozenblatt-Rosen O, Regev A, Teichmann SA. Science. pubmed:28983043; doi:10.1126/science.aan6828
28. RNA targeting with CRISPR-Cas13. Abudayyeh OO, Gootenberg JS, Essletzbichler P, Han S, Joung J, Belanto JJ, Verdine V, Cox DBT, Kellner MJ, Regev A, Lander ES, Voytas DF, Ting AY, Zhang F. Nature. pubmed:28976959; doi:10.1038/nature24049
29. AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Chow RD, Guzman CD, Wang G, Schmidt F, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ, Chen S. Nat Neurosci. pubmed:28805815; doi:10.1038/nn.4620
30. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Polak P, Kim J, Braunstein LZ, Karlic R, Haradhavala NJ, Tiao G, Rosebrock D, Livitz D, Kubler K, Mouw KW, Kamburov A, Maruvka YE, Leshchiner I, Lander ES, Golub TR, Zick A, Orthwein A, Lawrence MS, Batra RN, Caldas C, Haber DA, Laird PW, Shen H, Ellisen LW, D'Andrea AD, Chanock SJ, Foulkes WD, Getz G. Nat Genet. pubmed:28825726; doi:10.1038/ng.3934
31. Massively parallel single-nucleus RNA-seq with DroNc-seq. Habib N, Avraham-Davidi I, Basu A, Burks T, Shekhar K, Hofree M, Choudhury SR, Aguet F, Gelfand E, Ardlie K, Weitz DA, Rozenblatt-Rosen O, Zhang F, Regev A. Nat Methods. pubmed:28846088; doi:10.1038/nmeth.4407
32. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Cancer Cell. pubmed:28966034; doi:10.1016/j.ccell.2017.08.018
33. Cohesin Loss Eliminates All Loop Domains. Rao SSP, Huang SC, Glenn St Hilaire B, Engreitz JM, Perez EM, Kieffer-Kwon KR, Sanborn AL, Johnstone SE, Bascom GD, Bochkov ID, Huang X, Shamim MS, Shin J, Turner D, Ye Z, Omer AD, Robinson JT, Schlick T, Bernstein BE, Casellas R, Lander ES, Aiden EL. Cell. pubmed:28985562; doi:10.1016/j.cell.2017.09.026
34. Survival of pancreatic cancer cells lacking KRAS function. Muzumdar MD, Chen PY, Dorans KJ, Chung KM, Bhutkar A, Hong E, Noll EM, Sprick MR, Trumpp A, Jacks T. Nat Commun. pubmed:29061961; doi:10.1038/s41467-017-00942-5
35. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T. Elife. pubmed:28967864; doi:10.7554/eLife.28083
36. Aneuploid cell survival relies upon sphingolipid homeostasis. Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik AA, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A. Cancer Res. pubmed:28775166; doi:10.1158/0008-5472.CAN-17-0049
37. mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM. Cell. pubmed:29053970; doi:10.1016/j.cell.2017.09.046
38. EMT, CSCs, and drug resistance: the mechanistic link and clinical implications. Shibue T, Weinberg RA. Nat Rev Clin Oncol. pubmed:28397828; doi:10.1038/nrclinonc.2017.44
39. Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Feng YX, Jin DX, Sokol ES, Reinhardt F, Miller DH, Gupta PB. Nat Commun. pubmed:29057869; doi:10.1038/s41467-017-01052-y
40. Heterochiral Knottin Protein: Folding and Solution Structure. Mong S, Cochran F, Yu H, Graziano ZA, Lin YS, Cochran JR, Pentelute BL. Biochemistry. pubmed:28952732; doi:10.1021/acs.biochem.7b00722