The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: May 2017

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1. Delivering safer immunotherapies for cancer. Milling L, Zhang Y, Irvine DJ. Adv Drug Deliv Revpubmed:28545888;  doi:10.1016/j.addr.2017.05.011

2. Harnessing the hygroscopic and biofluorescent behaviors of genetically tractable microbial cells to design biohybrid wearables. Wang W, Yao L, Cheng CY, Zhang T, Atsumi H, Wang L, Wang G, Anilionyte O, Steiner H, Ou J, Zhou K, Wawrousek C, Petrecca K, Belcher AM, Karnik R, Zhao X, Wang DIC, Ishii H. Sci Advpubmed:28560325;  doi:10.1126/sciadv.1601984

3. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Jorgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E. Fertil Sterilpubmed:28433374;  doi:10.1016/j.fertnstert.2017.03.013

4. Synergistic interactions with PI3K inhibition that induce apoptosis. Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray NS, Hahn WC. Elifepubmed:28561737;  doi:10.7554/eLife.24523

5. Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants. Spencer KC, Sy JC, Ramadi KB, Graybiel AM, Langer R, Cima MJ. Sci Reppubmed:28512291;  doi:10.1038/s41598-017-02107-2

6. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS. Nat Cell Biolpubmed:28436968;  doi:10.1038/ncb3517

7. Investigating the cellular specificity in tumors of a surface converting nanoparticle by multimodal imaging. Fay F, Hansen L, Hectors SJ, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJ, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Perez-Medina C, Mulder WJ. Bioconjug Chempubmed:28316241;  doi:10.1021/acs.bioconjchem.7b00086

8. Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks. Yesilyurt V, Ayoob AM, Appel EA, Borenstein JT, Langer R, Anderson DG. Adv Materpubmed:28295624;  doi:10.1002/adma.201605947

9. Single-molecule detection of protein efflux from microorganisms using fluorescent single-walled carbon nanotube sensor arrays. Landry MP, Ando H, Chen AY, Cao J, Kottadiel VI, Chio L, Yang D, Dong J, Lu TK, Strano MS. Nat Nanotechnolpubmed:28114298;  doi:10.1038/nnano.2016.284

10. Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. Cell Reppubmed:28514657;  doi:10.1016/j.celrep.2017.04.021

11. Erythropoietin signaling regulates heme biosynthesis. Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH. Elifepubmed:28553927;  doi:10.7554/eLife.24767

12. Enforcement of developmental lineage specificity by transcription factor Oct1. Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin D. Elifepubmed:28537559;  doi:10.7554/eLife.20937

13. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sanchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT. Genes Devpubmed:28607179;  doi:10.1101/gad.295857.117

14. Inference and Evolutionary Analysis of Genome-Scale Regulatory Networks in Large Phylogenies. Koch C, Konieczka J, Delorey T, Lyons A, Socha A, Davis K, Knaack SA, Thompson D, O'Shea EK, Regev A, Roy S. Cell Systpubmed:28544882;  doi:10.1016/j.cels.2017.04.010

15. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJ, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, Fang X, Regev A, Suva ML, Hwang TH, Locasale JW, Bao S, Rich JN. Nat Neuroscipubmed:28346452;  doi:10.1038/nn.4537

16. Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation during Aging in Mice by Altering the Intestinal Microbiota. Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. Gastroenterologypubmed:28552621;  doi:10.1053/j.gastro.2017.05.022

17. Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. Hara M, Petrova B, Orr-Weaver TL. Elifepubmed:28555567;  doi:10.7554/eLife.22219

18. Loss of hepatic DEPTOR alters the metabolic transition to fasting. Caron A, Mouchiroud M, Gautier N, Labbe SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gelinas Y, Marette A, Richard D, Sabatini DM, Laplante M. Mol Metabpubmed:28462079;  doi:10.1016/j.molmet.2017.02.005

19. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. Olenchock BA, Rathmell JC, Vander Heiden MG. Immunitypubmed:28514672;  doi:10.1016/j.immuni.2017.04.013

20. When cancer needs what's non-essential. Sullivan MR, Vander Heiden MG. Nat Cell Biolpubmed:28422952;  doi:10.1038/ncb3523

21. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T. Naturepubmed:28489818;  doi:10.1038/nature22334

22. Metabolic Teamwork in the Stem Cell Niche. Roper J, Yilmaz OH. Cell Metabpubmed:28467944;  doi:10.1016/j.cmet.2017.04.019

23. The brain, sirtuins, and ageing. Satoh A, Imai SI, Guarente L. Nat Rev Neuroscipubmed:28515492;  doi:10.1038/nrn.2017.42

24. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM. J Immunolpubmed:28348273;  doi:10.4049/jimmunol.1601743

25. Toward Responsible Human Genome Editing. Hynes RO, Coller BS, Porteus M. JAMApubmed:28395003;  doi:10.1001/jama.2017.4548