Progress: May 2017
1. Delivering safer immunotherapies for cancer. Milling L, Zhang Y, Irvine DJ. Adv Drug Deliv Rev. pubmed:28545888; doi:10.1016/j.addr.2017.05.011
2. Harnessing the hygroscopic and biofluorescent behaviors of genetically tractable microbial cells to design biohybrid wearables. Wang W, Yao L, Cheng CY, Zhang T, Atsumi H, Wang L, Wang G, Anilionyte O, Steiner H, Ou J, Zhou K, Wawrousek C, Petrecca K, Belcher AM, Karnik R, Zhao X, Wang DIC, Ishii H. Sci Adv. pubmed:28560325; doi:10.1126/sciadv.1601984
3. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Jorgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E. Fertil Steril. pubmed:28433374; doi:10.1016/j.fertnstert.2017.03.013
4. Synergistic interactions with PI3K inhibition that induce apoptosis. Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray NS, Hahn WC. Elife. pubmed:28561737; doi:10.7554/eLife.24523
5. Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants. Spencer KC, Sy JC, Ramadi KB, Graybiel AM, Langer R, Cima MJ. Sci Rep. pubmed:28512291; doi:10.1038/s41598-017-02107-2
6. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS. Nat Cell Biol. pubmed:28436968; doi:10.1038/ncb3517
7. Investigating the cellular specificity in tumors of a surface converting nanoparticle by multimodal imaging. Fay F, Hansen L, Hectors SJ, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJ, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Perez-Medina C, Mulder WJ. Bioconjug Chem. pubmed:28316241; doi:10.1021/acs.bioconjchem.7b00086
8. Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks. Yesilyurt V, Ayoob AM, Appel EA, Borenstein JT, Langer R, Anderson DG. Adv Mater. pubmed:28295624; doi:10.1002/adma.201605947
9. Single-molecule detection of protein efflux from microorganisms using fluorescent single-walled carbon nanotube sensor arrays. Landry MP, Ando H, Chen AY, Cao J, Kottadiel VI, Chio L, Yang D, Dong J, Lu TK, Strano MS. Nat Nanotechnol. pubmed:28114298; doi:10.1038/nnano.2016.284
10. Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM. Cell Rep. pubmed:28514657; doi:10.1016/j.celrep.2017.04.021
11. Erythropoietin signaling regulates heme biosynthesis. Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH. Elife. pubmed:28553927; doi:10.7554/eLife.24767
12. Enforcement of developmental lineage specificity by transcription factor Oct1. Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin D. Elife. pubmed:28537559; doi:10.7554/eLife.20937
13. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sanchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT. Genes Dev. pubmed:28607179; doi:10.1101/gad.295857.117
14. Inference and Evolutionary Analysis of Genome-Scale Regulatory Networks in Large Phylogenies. Koch C, Konieczka J, Delorey T, Lyons A, Socha A, Davis K, Knaack SA, Thompson D, O'Shea EK, Regev A, Roy S. Cell Syst. pubmed:28544882; doi:10.1016/j.cels.2017.04.010
15. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJ, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, Fang X, Regev A, Suva ML, Hwang TH, Locasale JW, Bao S, Rich JN. Nat Neurosci. pubmed:28346452; doi:10.1038/nn.4537
16. Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation during Aging in Mice by Altering the Intestinal Microbiota. Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X. Gastroenterology. pubmed:28552621; doi:10.1053/j.gastro.2017.05.022
17. Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. Hara M, Petrova B, Orr-Weaver TL. Elife. pubmed:28555567; doi:10.7554/eLife.22219
18. Loss of hepatic DEPTOR alters the metabolic transition to fasting. Caron A, Mouchiroud M, Gautier N, Labbe SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gelinas Y, Marette A, Richard D, Sabatini DM, Laplante M. Mol Metab. pubmed:28462079; doi:10.1016/j.molmet.2017.02.005
19. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. Olenchock BA, Rathmell JC, Vander Heiden MG. Immunity. pubmed:28514672; doi:10.1016/j.immuni.2017.04.013
20. When cancer needs what's non-essential. Sullivan MR, Vander Heiden MG. Nat Cell Biol. pubmed:28422952; doi:10.1038/ncb3523
21. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T. Nature. pubmed:28489818; doi:10.1038/nature22334
22. Metabolic Teamwork in the Stem Cell Niche. Roper J, Yilmaz OH. Cell Metab. pubmed:28467944; doi:10.1016/j.cmet.2017.04.019
23. The brain, sirtuins, and ageing. Satoh A, Imai SI, Guarente L. Nat Rev Neurosci. pubmed:28515492; doi:10.1038/nrn.2017.42
24. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM. J Immunol. pubmed:28348273; doi:10.4049/jimmunol.1601743
25. Toward Responsible Human Genome Editing. Hynes RO, Coller BS, Porteus M. JAMA. pubmed:28395003; doi:10.1001/jama.2017.4548