The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Richard O. Hynes

Richard O. Hynes is the Daniel K. Ludwig Professor for Cancer Research

Daniel K. Ludwig Professor for Cancer Research

 

KI Research Areas of Focus:
Metastasis

"Our laboratory is interested in understanding the mechanisms underlying metastasis, the spread of tumor cells throughout the body. We are particularly involved in studying the role of the extracellular matrix, a meshwork of proteins that surrounds both normal and tumor cells and plays many important roles in tumor progression.”

Professor Hynes is Daniel K. Ludwig Professor for Cancer Research at MIT. He received his bachelor's degree in biochemistry from the University of Cambridge, , and his doctorate in biology from MIT. After postdoctoral work at the Imperial Cancer Research Fund in London, where he initiated his work on cell adhesion, he returned to MIT as a faculty member. Hynes is a Fellow of the Royal Society of London, the American Academy of Arts and Sciences, the American Association for the Advancement of Science, AACR and ASCB and a member of the US National Academies of Sciences and Medicine. He received the Canada Gairdner International Award, the Pasarow Foundation Medical Research Award, the Benditt Award from the North American Vascular Biology Organization, the E.B. Wilson Medal from the American Society for Cell Biology (ASCB) and the David Rall medal from NAM. He previously headed MIT’s Biology Department, and served as Director of the MIT Center for Cancer Research. He co-chaired the NAS Committees on Human Embryonic Stem Cells and on Human Genome Editing. He is currently on the Cold Spring Harbor Cancer Center Advisory Committee, the MGH Executive Committee on Research and the Rosenstiel Award Selection Committee. Dr. Hynes serves on the Scientific Resource Board of Genentech, the Research Trends and Emerging Technologies Advisory Board of Amgen, and the Scientific Advisory Board of Blade Therapeutics.

Further Information

Research Summary

Most cells adhere to their neighbors and to the extracellular matrix, a fibrillar meshwork surrounding or underlying most cells in the body. Cell adhesion plays important roles in the normal functions of cells, contributing to cellular organization and structure, proliferation and survival, and gene expression. Appropriate cell adhesion is necessary for numerous physiological processes and can be perturbed in many diseases, including cancer. The Hynes laboratory seeks to understand the proteins involved in cell adhesion and the ways in which they control adhesion and migration of cells in both normal and pathological processes.

A major focus of the Hynes lab is cancer, a disease in which cell adhesion plays many important roles. Researchers in the Hynes group are particularly interested in understanding the mechanisms that control the metastatic spread of cancer cells throughout the body and the multiple functions of the extracellular matrix during cancer progression. The team is investigating changes in the tumor cells themselves and in their surrounding microenvironment, or niche, which includes both normal cells and the extracellular matrix. The matrix changes extensively during tumor progression and metastasis, and the Hynes lab is playing a leading role in analyzing these changes using proteomic methods, which reveal the full collection of proteins involved. Extracellular matrix (ECM) constitutes an important part of the microenvironment of tumor cells, providing signals for their growth and survival and also contributing to the development of resistance to radio- and chemo-therapy. This resistance is one of the challenging aspects of cancer therapy.      

In recent work the laboratory has developed nanobodies to ECM proteins elevated in the metastatic niche and shown their effectiveness in selectively imaging tumors, including early lesions and metastases using PET/CT and other imaging methods.  This selective targeting of tumor ECM can also be used to deliver therapeutic agents to tumors and metastases, including CAR T cells that promote and immune response to solid tumors.  These approaches offer promise for clinical applications.

For more information about Professor Hynes's research, please visit the Hynes lab webpage.

Selected Publications

Jailkhani N, Ingram JR, Rashidian M, Rickelt S, Tian C, Mak H, Jiang Z, Ploegh H, Hynes RO. 2019.  Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.  Proc Natl Acad Sci U S A. 116:14181-14190.

Xie J, Dougan M, Jailkhani N, Ingram JR, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H. 2019. Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.  Proc Natl Acad Sci U S A. 116:7624-7631

Lamar JM, Xiao Y, Norton E, Jiang ZG, Gerhard GM, Kooner S, Warren JSA, Hynes RO. 2018.  Src tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis.  J.Biol. Chem. 294:2302-2317.

Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO. 2018. Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.  Elife. 2018 Jan 2;7. pii: e29494. doi: 10.7554/eLife.29494.

Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes, RO. 2016. The extracellular matrix: tools and insights for the “omics” era. Matrix Biol. 49: 10-24.

Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO. 2015. a5 and av integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo.  Development 142: 797-808. 

Labelle M, Begum S, Hynes RO. 2014. Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci USA 111: E3053-3061.

Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO. 2014. Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14: 518.

Naba A, Clauser KR, Lamar JM, Carr SA, Hynes RO. 2014. Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters. Elife 3: e01308.

Hynes RO. 2009. The Extracellular Matrix: not just pretty fibrils. Science 326: 1216-1219.

Search PubMed for Hynes lab publications

Contact Information

Richard O. Hynes

room 76-361
phone (617) 253-6422
email rohynes@mit.edu

Hynes Lab

phone (617) 253-3025
fax (617) 253-8357
website

Laboratory Administrator:

Xiaotie Liu
phone (617) 253-6409
email xiaotie@mit.edu