immunofluorescent image of a tumor

Immuno-Pep Squad


The immune system’s ability to detect nascent tumors requires the presentation of protein fragment (peptide) antigens that it can recognize. Due to limitations in how samples are collected and studied, researchers have difficulty identifying peptide presentation patterns specific to cancer. However, an ongoing Jacks Lab/White Lab collaboration, originally begun as a hallway conversation between colleagues, shows the power of combining engineered mouse models with mass spectrometry to better profile the collection of immunopeptides on the surface of cancer cells. The researchers' latest paper, published in Nature, reveals new tumor antigens potentially useful for immunotherapies and understanding of immune response.

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KI Director to be Named to National Cancer Advisory Board

The White House

In the White House announcement of his appointment, Koch Institute Director Tyler Jacks was recognized by the President for his depth of experience and tremendous dedication to cancer research.

Koch Institute and OMJP launch TRANSCEND

MIT News

KI announced a major strategic partnership with Ortho-McNeil-Janssen Pharmaceuticals, Inc., and its affiliates, called TRANSCEND, whereby the parties will begin to collaborate in multiple areas of oncology research and technology development.

KI to host a new Center for Cancer Systems Biology

MIT News

This past week, the David H. Koch Institute for Integrative Cancer Research at MIT received funding from the National Cancer Institute (NCI) to become a Center for Cancer Systems Biology (CCSB). These centers are part of NCI's Integrative Cancer Biology Program (ICBP), which is the NCI's primary effort in cancer systems biology, a field that is rapidly seen as an essential component in the future of cancer research.

Koch Institute collaborative teams expand to include physicists

MIT News

Cancer research has traditionally been the realm of biologists, and, more recently, engineers. Now, physicists are getting in on the action. MIT has been awarded a five-year grant from the National Cancer Institute (NCI) to start a new Physical Science-Oncology Center. The funding, approximately $3.5 million per year, will support four cancer research projects led by MIT physical scientists.

David H. Koch Gives $100 Million to MIT for Cancer Research

MIT News

MIT has announced a $100 million gift from Koch Industries executive and MIT alumnus David H. Koch that will usher in new paradigms in highly integrative cancer research. The gift will bring together MIT scientists and engineers under one roof to develop new and powerful ways to detect, diagnose, treat, and manage this often deadly disease.