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MIT Advocacy in Action at the AACR’s 2025 Hill Day

Koch Institute

MIT Koch Institute postdoc Meaghan McGeary traveled to Washington, DC to advocate for increased federal funding for cancer research as part of the annual American Association for Cancer Research (AACR) Hill Day. Joining other early-career scientists in a mission to make more than 50 congressional visits in a single day, she shared her experiences with policymakers, emphasizing the importance of stable research funding.  

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The Measuring Tape Heard Round the World

MIT News

Nancy Hopkins joined author and New York Times journalist Kate Zernike for a discussion of The Exceptions. The book tells the story of Hopkins' life and career, and of the 15 “exceptional” female scientists on the MIT faculty who joined Hopkins to document gender discrimination at MIT and fight for equality. Armed with a measuring tape, Hopkins began by quantifying the inequitable distribution of lab space among male and female faculty. Her findings would catalyze the  landmark 1999  report, "A Study on the Status of Women Faculty on Science at MIT," detailing the barriers standing in the way of women who want to pursue degrees and careers in science.

Elicio Doses First Patient

BioSpace

Elicio Therapeutics, which is developing the Irvine Lab’s lymph node targeting vaccine technology, has dosed its first patient of a Phase 1/2 clinical trial of a treatment of KRAS/NRAS mutated solid tumors in pancreatic and colorectal cancer patients. 

What’s Next for Alejandro Aguilera Castrejón

MIT Koch Institute

Catch up with Alejandro Aguilera Castrejón, an inaugural winner of the Angelika Amon Young Scientist Award in 2022. Aguilera talks about his plans for building on his doctoral work in embryogenesis and starting a new lab when he begins his new role as a group leader at HHMI’s Janelia Research Campus in March 2024.

Stimulating Hunger

MIT News

An ingestible capsule that delivers an electrical current can stimulate the release of the hormone ghrelin. Developed in the lab of KI alum Giovanni Traverso, the capsule could prove useful for treating diseases that involve nausea or loss of appetite, such as anorexia or cachexia (loss of body mass that can occur in patients with cancer or other chronic diseases).

Raising the Barcode for Cancer Detection

MIT News

The Bhatia Lab designed a new nanoparticle sensor that, like its previous sensors, could enable early, affordable, and accessible diagnosis of cancer with a simple urine test. As described in Nature Nanotechnology, when the nanoparticles encounter a tumor, they shed DNA “barcodes” into the urine, which can be read on a simple paper strip and analyzed in a medical lab to detect cancer, distinguish between tumor types, or monitor response to treatment.

The research was supported in part by the Marble Center for Cancer Nanomedicine and the Koch Institute Frontier Research Program via the Kathy and Curt Marble Cancer Research Fund.

Neel Bardhan Named Break Through Cancer Scientist

Break Through Cancer

Congratulations to Neelkanth Bardhan on being named a Break Through Cancer Scientist! Professional scientists in the role cooperate on and lead projects, lending their skill, knowledge and insight to maximize the impact of Break Through Cancer's cross-institutional collaborations. Bardhan works with the Intercepting Ovarian Cancer TeamLab, helping design an optical imaging system for highly sensitive detection of early precursor lesions in ovarian cancer.

Printable Vaccines

MIT News

Researchers in the Jaklenec and Langer labs have designed a mobile vaccine printer that could be scaled up to produce hundreds of vaccine doses in a day. This kind of printer, which can fit on a tabletop, could be deployed anywhere vaccines are needed, no cold storage required. The printer produces patches with hundreds of microneedles containing vaccine. The patch can be attached to the skin, allowing the vaccine to dissolve without the need for a traditional injection. In a study appearing in Nature Biotechnology, the researchers showed they could use the printer to produce thermostable Covid-19 RNA vaccines that could induce a comparable immune response to that generated by injected RNA vaccines, in mice.

Steven Truong Awarded Soros Fellowship for New Americans

MIT News

Steven Truong, a Koch Institute alum, has been awarded a 2023 Paul and Daisy Soros Fellowship for New Americans. Currently an MD-PhD student at Stanford, he aspires to help solve and treat metabolic disorders such as diabetes. Truong graduated from MIT in 2020 with a double major in biological engineering and writing, and worked in the Langer and Anderson Labs to develop smart insulins and in the Lauffenburger Lab to study the link between the immune system and diabetes.

Emit at MIT

Emit Imaging

Emit Imaging, Inc. will launch a project with the MIT Koch Institute's Preclinical Imaging and Testing Facility to enhance 3D imaging technology. The project will incorporate the Koch Institute’s research-based experiences into cryo-fluorescence tomography (CFT) workflow and method improvements, allowing for greater accuracy and efficiency in studying cancer and other diseases. Emit's CFT technology is a 3D imaging technique that allows for high-resolution, high-sensitivity imaging of biological samples, providing crucial insights into the behavior of drugs and proteins. 

Brushing Away Side Effects

MIT News

An interdisciplinary team of Koch Institute researchers designed bottlebrush-shaped nanoparticles that provoke immune response against tumors. In a study appearing in Science Advances, researchers from the Johnson, Irvine, Spranger, Langer, and Shalek labs based their nanoparticle prodrug on imidazoquinolines, a class of drugs that activates the immune system against cancer, but can also trigger significant side effects when administered intravenously. The prodrug, or an inactivated form of the medicine, is bound to the bottlebrush backbone, timed to be released in active form once it reaches the tumor. Mice treated with the nanoparticles showed a significant reduction in tumor growth, and showed no side effects.

This study was supported in part by the Koch Institute Frontier Research Program via the Kathy and Curt Marble Cancer Research Fund, and the Marble Center for Cancer Nanomedicine.