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Tailor-made genes

MIT News

April 30, 2025

Katie Galloway and her team developed synthetic gene circuits that enable more precise control of gene therapy. Their research, published in Cell Systems, could lead to new treatments for fragile X syndrome and other diseases caused by mutations in a single gene, ensuring more safe and effective therapeutic outcomes.

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Showing 121–130 of 624 stories

MIT’s Tiny Technologies Go to Washington

MIT Koch Institute

December 4, 2023

A team from the Marble Center for Cancer Nanomedicine showed a Washington D.C. audience several examples of how nanotechnologies developed at the Koch Institute can transform the detection and treatment of cancer and other diseases. At "American Possibilities: A White House Demo Day,” principal research scientist Ana Jaklenec highlighted several groundbreaking technologies developed her group to improve vaccines and disease diagnostics and treatment. Jeremy Li, CEO and co-founder of Cision Vision and former Belcher Lab postdoc, presented a lymph node imaging device that has been named one of Time Magazine’s Best Inventions of 2023 and is currently being used in a dozen hospitals across the U.S.
 

The Sweet Side of Cell Biology

MIT News

December 1, 2023

As a field, glycoscience—the study of the carbohydrates and sugar-coated molecules found in every living organism—is in the midst of a renaissance that could reshape scientists' understanding of the building blocks of life and the drivers of disease. An MIT News explainer gives a taste of the sweet science pursued around campus, including  research into glycans’ critical roles in normal and cancer biology by KI investigators Laura Kiessling, Tobi Oni, and Jessica Stark.

Immune Action at a Distance

MIT News

November 30, 2023

The Traverso Lab developed a gel-based platform for injecting immune-stimulating drugs directly into tumors. Ideally, direct injection of these drugs into a tumor will provoke a system-wide immune response, while avoiding the serious toxic side effects of systemic administration. In practice, tumors are difficult to target with precision and the drugs tend to leak away from the tumor too quickly. The team worked with colleagues at Mass General Brigham to design a thermoresponsive gel that is visible with a CT scanner, solidifies after injection, and releases drugs at a controlled rate. An Advanced Healthcare Materials study showed that in combination with checkpoint blockade therapy, the platform caused both treated tumors and untreated tumors at other locations to regress in mouse models.

Congratulations to our 2023 Karches Prize Winners

MIT Koch Institute

November 28, 2023

The annual Peter Karches Mentorship Prize recognizes the exemplary mentorship of up to four postdoctoral researchers, graduate students or technicians from across Koch Institute laboratories. This year’s recipients are Ryuhjin (Angela) Ahn, Mushriq Al-Jazrawe, Colin Fowler, and B.J. Kim. Congratulations to all!

Multi-Molecule Tracker

MIT News

November 28, 2023

Using fluorescent labels that switch on and off, the Boyden Lab has developed a method for simultaneously tracking several molecular interactions inside the cell. The technique, described in Cell, could help researchers better understand what happens inside cells, including in diseases such as cancer.

KI Faculty Members win Mark Foundation ASPIRE Award

The Mark Foundation

November 15, 2023

Cheers to the Koch Institute's four recipients of the 2023 Mark Foundation Aspire Award! Darrell Irvine and Dane Wittrup received an award for their project, “Induction of Tumor-Eradicating Systemic Immunity via Leukocyte-Targeted Cytokine Therapy.” Regina Barzilay and Tyler Jacks won an award in support their work to develop “AI-Driven Modeling of T Cell Receptors.”

Birnbaum Named Pew Innovation Fund Investigator

MIT News

November 14, 2023

Congratulations to Michael Birnbaum on being named a Pew Innovation Fund Investigator. Together with co-winner Dan Littman, he will investigate how microbes and antigens drive harmful immune responses in the gut in inflammatory bowel disease.

In Memoriam, Dr. Arthur Gelb, 1937-2023

MIT Koch Institute

November 14, 2023

With sadness, the KI marks the passing of long-time supporter Art Gelb, ScD ’61 (XVI), whose advocacy and philanthropy played key roles in the launch of the Bridge Project. The Bridge Project launched shortly after the opening of the Koch Institute and has continued to grow, enabling work by dozens of teams who are developing notable advances in cancer detection, monitoring, and treatment. We gratefully acknowledge Gelb’s vision, commitment, and generosity, and are honored to be part of his living legacy via the Bridge Project.

Introducing the 2023-2024 Convergence Scholars

MIT Koch Institute

November 13, 2023

The Marble Center for Cancer Nanomedicine and the MIT Center for Precision Cancer Medicine are pleased to announce the 2023-2024 class of Convergence Scholars. Founded in 2017, the Convergence Scholars Program (CSP) is designed to enhance the career development of aspiring independent scientists with diverse interests across academia, industry, science communication, and STEM outreach. This year's scholars are Jonuelle Acosta (Hemann Lab), Margaret Billingsley (Hammond Lab), Asheley Chapman (Irvine Lab), Allison Greaney (Langer Lab), Yizong Hu (Anderson Lab), Vardhman Kumar (Bhatia Lab), Corey Stevens (Belcher Lab), Elen Torres (Spranger Lab), and Bocheng Wu (Koehler Lab).

10 Years of the Bridge Project

MIT Koch Institute

November 10, 2023

In large part the brainchild of the late Art Gelb, ScD ’61, the Bridge Project was launched in 2012 with a simple idea uniquely suited to Greater Boston. Designed to leverage the collective expertise of MIT and Harvard, particularly its clinical cancer centers and teaching hospitals, the program’s goal is to enable collaborative research teams combining innovative science, tools and technologies with the translational expertise of clinical oncologists to solve challenging problems in cancer.