The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

In the News

Faculty Position Available

The Koch Institute for Integrative Cancer Research invites applications for a junior or senior faculty appointment. Appointments are expected to be in the MIT Department of Biology, but other departments will be considered if appropriate.This is an open search with regard to field of study and specific research focus, and research programs focused on basic science questions are potentially appropriate, but some cancer relevance will be a consideration. Learn more and apply online. Complete applications are due by November 1, 2017. more...

Aren't they Wunder-ful?

Salil Garg (Sharp Lab), Jiang He (Bhatia Lab), and Michael Mitchell (Langer Lab) were all named 2017 STAT Wunderkinds for their work "blazing new trails as they attempt to answer some of the biggest questions in medicine." Langer Lab alumni Carl Schoellhammer, CEO of Suonobio, and Armon Sharei, CEO of SQZ Biotech, were both among Business Insider's 30 biotech leaders under 40 list.  Sharei also received the "Young Innovator" award at this year's Xconomy Awards! more...

Ritu Raman, a postdoc in the Langer Lab at the Koch Institute at MIT, has been named a 2017 L’Oréal USA for Women in Science Fellow.

Ritu Raman named L’Oréal USA for Women in Science Fellow

In recognition of her contributions to the advancement of STEM fields and for her support of women and girls in science, Langer Lab postdoc Ritu Raman has been awarded the L’Oréal USA For Women in Science Fellowship. The L’Oréal USA For Women in Science Fellowship recognizes female scientists at a critical early stage in their careers with grants to advance their postdoctoral research. Raman, who was also recently named one of six Convergence Scholars by the Marble Center for Cancer Nanomedicine, plans to use her L’Oréal USA award funds to support her research developing bio-hybrid materials for long-term sensing and drug delivery and her collaborations with scientists, engineers, and clinicians across the country. A staunch advocate for STEM education and outreach, Ritu hopes to one day open her own lab to teach others how to build with adaptive materials and develop curricula that explore the ethics and mechanics of building with biology. more...

Richard Hynes, Koch Institute at MIT member and Daniel K. Ludwig Professor for Cancer Research, named the recipient of the 2017 David Rall Medal from the National Academy of Medicine (NAM).

Hynes Receives National Academy of Medicine Honor

Congratulations to KI member and Daniel K. Ludwig Professor for Cancer Research, Richard Hynes, for being named the recipient of the 2017 David Rall Medal from the National Academy of Medicine (NAM). Hynes was chosen for his leadership as the co-chair of the NAM/NAS Report Committee on Human Genome Editing. To honor his recent award, Hynes sat down with NAM to discuss his research, his inspiration for getting involved in policy work, and his thoughts on how to better engage public interest in science and medicine — read here. more...

Langer Receives Kabiller Prize

There's na-no ifs, ands, or buts about it — nanotechnology is clearly a driving force in the prolific career of Robert Langer, member of the KI and the Marble Center for Cancer Nanomedicine. For his work on the design and development of novel carriers for improved small molecule drug delivery, Langer was awarded the 2017 Kabiller Prize in Nanoscience and Nanomedicine from Northwestern University’s International Institute for Nanotechnology. The Kabiller Prize honors outstanding achievement in the field of nanotechnology and its application to medicine and biology. Read more about Langer's latest honor, view the accompanying video, or listen to him on the NorthwesternU podcast. more...

Rave Tech Reviews for KI Community Members

The September/October issue of MIT Technology Review celebrates the accomplishments of three Koch Institute community members. A powerful feature story about Nancy Hopkins, KI member and MIT professor emerita, reflects on her role as a leading force for gender equity in science, the increased opportunities for women in science and engineering that have emerged at MIT and beyond as a result of her efforts, and the work that is still underway in this area. Another highlight of the issue is the 2017 list of "35 Innovators Under 35," where you can spot Love Lab alumnus Viktor Adalsteinsson in the "Visionaries" category for his work on liquid biopsies for early cancer detection and monitoring treatment response. And last, but certainly not least, Paula Hammond shines in an alumna profile focused on her career and current work creating nanoscale biomaterials to improve cancer treatments. more...

The Comings and Goings of KI Faculty Members

The Koch Institute bids a fond farewell to members Stephen Lippard and Leona Samson in their retirement, and welcomes Bradley Pentelute to the KI fold.

Samson, who has been a cancer researcher for more than 40 years, joined the MIT faculty in 2001, where she has held appointments in the departments of Biology and Biological Engineering. Her work has focused on DNA repair; now, in retirement, she will alternate between Oxford, England and Cambridge, Massachusetts — we sincerely hope she won't be a stranger!

Lippard, who completed his PhD at MIT in 1965 and has been a professor in the Department of Chemistry since 1983, is now the Arthur Amos Noyes Professor Emeritus. Koch Institute devotees are familiar with Lippard's work as "the father of bioinorganic chemistry," and his efforts to find new medicines for cancer. He will no doubt remain active at the Institute through the annual Lippard Lecture, held in honor of his late wife Judith Ann Lippard.

New extramural faculty member, Pentelute, an Associate Professor in the Department of Chemistry, is inspired by biopolymers found in nature. His lab aims to invent new chemistry to modify proteins to enhance their therapeutic properties for human medicine. Pentelute joined the MIT faculty in 2011, received tenure in 2017, and joins KI members Stefani Spranger and Eliezer Calo as the newest faculty members of the Koch Institute family. Welcome, all! more...

New Academic Year Brings New KI Leadership

The Koch Institute is pleased to announce that KI faculty members Darrell Irvine and Matthew Vander Heiden have joined the Institute's leadership team as Associate Directors.

Irvine, Professor of Biological Engineering and Materials Science & Engineering, will step into this role to lead the Koch Institute's engineering initiatives and serve as a liaison with MIT's School of Engineering. Similarly, Vander Heiden, Associate Professor of Biology, will guide the KI's life sciences cohort and work closely with MIT's School of Science. With KI Director Tyler Jacks at the helm, Irvine and Vander Heiden join current Associate Director Jacqueline Lees, who has been an integral part of the leadership of the Koch Institute since its inception and of the Center for Cancer Research for six years before that. In addition to her continued involvment in all aspects of the administration, Lees will also continue to bring particular oversight to the 12 core facilities within the Swanson Biotechnology Center along with Sarah Farrington, Core Faciltities Administrator.

Dane Wittrup, who has served as Associate Director since the Koch Institute's founding in 2007, is stepping down from the leadership team. "I have very much enjoyed working with Dane in this capacity and thank him for his hard work and dedication," KI Director Tyler Jacks said. "I look forward to his continued contributions to the KI in the years ahead."

With fresh faces, new ideas, and sustained focus on representing our strengths in both engineering and life sciences, the 2017-2018 academic year is off to an exciting start at the KI! more...

A Strand-ing Ovation for mRNA Delivery

Weaving together expertise in polymer science and chemical engineering with inspiration from nature, Hammond Lab researchers — as published in Angewandte Chemie — have designed a bioinspired delivery system for messenger RNA (mRNA) that is far more efficient than delivering these strands of genetic material on their own. mRNA holds great promise for treating disease, including cancer, but presents numerous challenges in delivering them to cells for high gene expression. The team's approach, attaching poly-A binding proteins to the mRNA tail and assembling the complex with a polymer, translates into more effective delivery to ribosomes for increased production of desired proteins. This work was supported in part by a Koch Institute Quinquennial Cancer Research Fellowship. Read more. more...

Ultrasonic Power, Start The Engine!

Langer Lab startup Suono Bio continues to ride the waves of success — this month, the company was selected as one of seven founding startups to receive investment from The Engine, MIT's new "tough-tech" development venture. Co-founded by lab members Carl Schoellhammer and Gio Traverso, along with David H. Koch Institute Professor Robert Langer and Amy Schulman of Polaris Partners, Suono Bio is developing technology to rapidly deliver drugs, proteins, vaccines, and other molecules directly into the gastrointestinal tract using ultrasound waves. The company, led by Schoellhammer as CEO, competed with 500 different startups to receive long-term funding, resources, and services from The Engine's inaugural investment cycle. Read more. more...