The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Belcher Shines Brighter

fluorescence image of tumor cells with probes along the edge

In a paper published in Advanced Materials, the Belcher Lab demonstrated recent advancements to their imaging system. First, they paired short-wave infrared organic dye molecules with gold nanorods to increase the brightness of their fluorescent probes. Then, collaborating with the Hammond and Irvine groups, they designed three different surface coatings to help target the fluorescent probes to tumors. In ovarian cancer mouse models, the researchers showed that the probes are not only brighter, but that all three coatings target efficiently to tumors, making them ideal for use in real-time imaging guided surgery.
 
This work was funded in part by the Koch Institute Frontier Research Program through the Curt and Kathy Marble Cancer Research Fund.