The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Understanding the Spread of Lung Cancer

In a collaborative effort, researchers from the Jacks and Hynes laboratories applied quantitative proteomics to identify microenvironmental regulators of lung cancer metastasis. Their study, published in PNAS, identifies Tenascin-C, an extracellular matrix protein, as a novel lung cancer metastasis promoter and demonstrates the prognostic value of Tenascin-C expression for lung-cancer-patient survival. This study paves the way for future explorations of the tumor microenvironment, underexplored sources of diagnostic markers, and potential therapeutic targets for cancer patients.