Understanding the Spread of Lung Cancer

June 26, 2017

In a collaborative effort, researchers from the Jacks and Hynes laboratories applied quantitative proteomics to identify microenvironmental regulators of lung cancer metastasis. Their study, published in PNAS, identifies Tenascin-C, an extracellular matrix protein, as a novel lung cancer metastasis promoter and demonstrates the prognostic value of Tenascin-C expression for lung-cancer-patient survival. This study paves the way for future explorations of the tumor microenvironment, underexplored sources of diagnostic markers, and potential therapeutic targets for cancer patients.