October 22, 2015
October was a big month for KI research, with two publications featured as journal cover stories. In Clinical Cancer Research, researchers from the labs of Paula Hammond, David H. Koch Professor of Engineering, and Michael Yaffe, David H. Koch Professor of Science, describe a nanoscale drug formulation engineered with Hammond’s layer-by-layer technology. The nanoparticles simultaneously block two key cell signaling pathways in an animal model of breast cancer, thus evading drug resistance and enhancing cancer-cell death. Meanwhile, in Genes & Development, researchers from the lab of Angelika Amon, the Kathleen and Curtis Marble Professor in Cancer Research, report a new link between aneuploidy — the presence of an abnormal number of chromosomes, often found in cancer cells — and lysosomal stress due to an overload of aggregated proteins.