September 3, 2013
The Koch Institute gratefully remembers notable biologist Tony Pawson, who served as a member of the KI's Scientific Advisory Board for several years. Tony is perhaps best known for clarifying key protein interactions involved in cell signaling. Specifically, he identified the SH2 domain, a protein structure found on the surface of each cell that serves as the landing site for signaling proteins. From there information is carried to the cell nucleus and sets off a chain reaction telling cells what to do and when. Tony's discoveries fundamentally changed the understanding of cell processes and of diseases, like cancer, that occur when cell communication is disrupted. Launching an entirely new field of study, his work helped spur the development of drugs for cancer, diabetes, and other illnesses. We thank Tony for his inspiring contributions to science, and for his dedicated friendship and service.