Using its phosphorylation analysis tools, the White Lab has identified hundreds of enzymes, many linked to chronic stress response pathways, that cause metabolic dysfunction and weight gain when mice are fed high-fat diets. The study, led by Koch Institute alum Tigist Tamir and published in Molecular Cell, showed effects were more pronounced in male mice and that an antioxidant reversed most of the damage. Tamir continues their work on cell signaling and metabolism in obesity and cancer at University of North Carolina at Chapel Hill School of Medicine. This work was partly supported by the MIT Center for Precision Cancer Medicine and a fellowship from the Ludwig Center at MIT.