The Cancer Biology Program is engaged in studying cancer and cancer-relevant processes using genetic systems. A major shared research activity of the Cancer Biology research teams is an integrated analysis of cell cycle regulation using classical genetic systems, including Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus as well as cell-based experiments with normal and tumor-derived human cells. Other areas of common interest include the control of cell death and mitogenic signaling pathways. Important distinguishing feature of the research in Cancer Biology is the focus on whole-organism approaches and the relationship between normal development and tumor development. Several Cancer Biology laboratories are developing improved animal models of cancer to study aspects of tumor biology ranging from the genetics of initiation to metastatic progression. The development and validation of these models is greatly aided by recent advances in genome research and an array of post-genomic tools. In order to realize the goal of understanding the process of tumorigenesis in sufficient detail so as to rationally treat cancer or prevent its development, it will be necessary to elucidate the molecular basis of normal cell cycle regulation and other basic processes that are perturbed in the cancer cell.