The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Robert S. Langer

Robert S. Langer (Copyright Bachrach Photography)

David H. Koch Institute Professor

Member, Marble Center for Cancer Nanomedicine

 

KI Research Areas of Focus:
Nano-based Drugs, Cancer Immunology,
Personalized Medicine

"Our work is at the interface of biotechnology and materials science. A major focus is the study and development of polymers to deliver drugs, particularly genetically engineered proteins and DNA, continuously at controlled rates for prolonged periods of time. Our interest in drug delivery systems has extended to selective drug or substance removal systems that may circumvent toxicity. In addition, we are developing drugs that specifically inhibit the process of neovascularization that is critical to several disease processes without interfering with existing blood vessels. Finally, we have been involved in creating approaches to engineer new tissues. In particular, we are synthesizing new biodegradable polymer systems to be used in mammalian cell transplants to create liver, cartilage, and nerves, and are developing bioreactors for these purposes."

Robert Langer was born in Albany, New York.  He received his Bachelor's Degree from Cornell University (Ithaca, NY) in 1970 and his Sc.D. from the Massachusetts Institute of Technology (Cambridge, MA) in 1974, both in chemical engineering.

He is one of 12 Institute Professors at the Massachusetts Institute of Technology. He has written more than 1,400 articles and has over 1,300 issued and pending patents worldwide. 

Dr. Langer’s many awards include the US National Medal of Science, the US National Medal of Technology and Innovation, the Charles Stark Draper Prize (considered the engineering Nobel Prize), Albany Medical Center Prize (largest US medical prize), the Priestley Medal (2012), the Queen Elizabeth Prize (2015), the Wolf Prize for Chemistry, the 2014 Kyoto Prize, the 2019 Dreyfus Prize, and the Lemelson-MIT prize, for being “one of history’s most prolific inventors in medicine.” Langer is one of the very few individuals ever elected to the National Academy of Medicine, the National Academy of Engineering and the National Academy of Sciences. 

Robert Langer is a co-founder of many entities, including Momenta and Living Proof. He also serves on the Board of Directors of Moderna and Puretech, and serves as an advisor to a number of  other companies. Click here for a complete listing.

Selected Publications

Larson B, Yu S, Park H, Estes B, Moutos F, Bloomquist C, Wu P, Welter J, Langer R, Guilak F, Freed L. Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds, Tissue Engineering and Regenerative Medicine, 2019.

Langer R. Chemical and biological approaches to regenerative medicine and tissue engineering. Molecular Frontiers Journal, 3:2, 2019.

Riley R, June C, Langer R, Mitchell M. Delivery technologies for cancer immunotherapy. Nat. Rev. Drug Discov., 18:175-196, 2019.

Tzeng S, McHugh K, Behrens A, Rose S, Sugarman J, Ferber S, Langer R, Jaklenec A. Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response. PNAS, 115(23): E5269-E5278, 2018.

Y Lu, AA Aimetti, R Langer, Z Gu. Bioresponsive materials.  Nature Reviews Materials 2 (1), 16075, 2017.

AJ Vegas, O Veiseh, M Gürtler, JR Millman, FW Pagliuca, AR Bader, ...., R Langer, D Anderson. Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice.  Nature medicine 22 (3), 306. 2016

MW Tibbitt, JE Dahlman, R Langer. Emerging frontiers in drug delivery. Journal of the American Chemical Society 138 (3), 704-717.  2016

H Yin, CQ Song, JR Dorkin, LJ Zhu, Y Li, Q Wu, A Park, J Yang, S Suresh, A Bizhanova, A Gupta, M Bolukbasi, S Walsh, R Bogorad, G Gao, Z Weng, Y Dong, V Koteliansky, S Wolfe, R Langer, W Xue, D Anderson. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.  Nature biotechnology 34 (3), 328, 2016.

J Dahlman, C Barnes, O Khan, A Thiriot, S Jhunjunwala, T Shaw, Y Xing, H Sager, G Sahay, L Speciner…. R Langer, D Anderson. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nature nanotechnology 9 (8), 648, 2014.

S Mitragotri, PA Burke, R Langer.  Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies.  Nature reviews Drug discovery, 13 (9), 655, 2014.

G Sahay, W Querbes, C Alabi, A Eltoukhy, S Sarkar, C Zurenko, E Karagiannis, K Love, D Chen, R Zoncu, Y Buganim, A Schroeder, R Langer, D Anderson. Nature biotechnology, 31 (7), 653, 2013.

M Ma, L Guo, DG Anderson, R Langer.  Bio-inspired polymer composite actuator and generator driven by water gradients.  Science 339 (6116), 186-189, 2013.

Search PubMed for Langer lab publications

Robert S. Langer is the David H. Koch Institute Professor (there are 11 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member). Dr. Langer has written over 1,250 articles. He also has nearly 1,050 patents worldwide. Dr. Langer’s patents have been licensed or sublicensed to over 250 pharmaceutical, chemical, biotechnology and medical device companies. He is the most cited engineer in history.

He served as a member of the United States Food and Drug Administration’s SCIENCE Board, the FDA’s highest advisory board, from 1995 -- 2002 and as its Chairman from 1999-2002.

Dr. Langer has received over 220 major awards. He is one of 7 individuals to have received both the United States National Medal of Science (2006) and the United States National Medal of Technology and Innovation (2011). He also received the 2002 Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineers, the 2008 Millennium Prize, the world’s largest technology prize, the 2012 Priestley Medal, the highest award of the American Chemical Society, the 2013 Wolf Prize in Chemistry and the 2014 Breakthrough Prize in Life Sciences. He is the also the only engineer to receive the Gairdner Foundation International Award; 82 recipients of this award have subsequently received a Nobel Prize. Among numerous other awards Langer has received are the Dickson Prize for Science (2002), Heinz Award for Technology, Economy and Employment (2003), the Harvey Prize (2003), the John Fritz Award (2003) (given previously to inventors such as Thomas Edison and Orville Wright), the General Motors Kettering Prize for Cancer Research (2004), the Dan David Prize in Materials Science (2005), the Albany Medical Center Prize in Medicine and Biomedical Research (2005), the largest prize in the U.S. for medical research, induction into the National Inventors Hall of Fame (2006), the Max Planck Research Award (2008), the Prince of Asturias Award for Technical and Scientific Research (2008), the Warren Alpert Foundation Prize (2011) and the Terumo International Prize (2012). In 1998, he received the Lemelson-MIT prize, the world’s largest prize for invention for being “one of history’s most prolific inventors in medicine.” In 1989 Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences, and in 2012 he was elected to the National Academy of Inventors.

Forbes Magazine (1999) and Bio World (1990) have named Dr. Langer as one of the 25 most important individuals in biotechnology in the world. Discover Magazine (2002) named him as one of the 20 most important people in this area. Forbes Magazine (2002) selected Dr. Langer as one of the 15 innovators world wide who will reinvent our future. Time Magazine and CNN (2001) named Dr. Langer as one of the 100 most important people in America and one of the 18 top people in science or medicine in America (America’s Best). Parade Magazine (2004) selected Dr. Langer as one of 6 “Heroes whose research may save your life.” Dr. Langer has received honorary doctorates from Harvard University, the Mt. Sinai School of Medicine, Yale University, Western University (Canada), the ETH (Switzerland), the Technion (Israel), the Hebrew University of Jerusalem (Israel), the Universite Catholique de Louvain (Belgium), Rensselaer Polytechnic Institute, Willamette University, the University of Liverpool (England), Bates College, the University of Nottingham (England), Albany Medical College, Pennsylvania State University, Northwestern University, Uppsala University (Sweden), Tel Aviv University (Israel), Boston University, Ben Gurion University (Israel), Drexel University and the University of California – San Francisco Medal. He received his Bachelor’s Degree from Cornell University in 1970 and his Sc.D. from the Massachusetts Institute of Technology in 1974, both in Chemical Engineering. - See more at: http://www.oxbridgebiotech.com/events/biotech-boom-can-learn-banner-year/#sthash.B4F2WfTJ.dpuf
Robert S. Langer is the David H. Koch Institute Professor (there are 11 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member). Dr. Langer has written over 1,250 articles. He also has nearly 1,050 patents worldwide. Dr. Langer’s patents have been licensed or sublicensed to over 250 pharmaceutical, chemical, biotechnology and medical device companies. He is the most cited engineer in history.

He served as a member of the United States Food and Drug Administration’s SCIENCE Board, the FDA’s highest advisory board, from 1995 -- 2002 and as its Chairman from 1999-2002.

Dr. Langer has received over 220 major awards. He is one of 7 individuals to have received both the United States National Medal of Science (2006) and the United States National Medal of Technology and Innovation (2011). He also received the 2002 Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineers, the 2008 Millennium Prize, the world’s largest technology prize, the 2012 Priestley Medal, the highest award of the American Chemical Society, the 2013 Wolf Prize in Chemistry and the 2014 Breakthrough Prize in Life Sciences. He is the also the only engineer to receive the Gairdner Foundation International Award; 82 recipients of this award have subsequently received a Nobel Prize. Among numerous other awards Langer has received are the Dickson Prize for Science (2002), Heinz Award for Technology, Economy and Employment (2003), the Harvey Prize (2003), the John Fritz Award (2003) (given previously to inventors such as Thomas Edison and Orville Wright), the General Motors Kettering Prize for Cancer Research (2004), the Dan David Prize in Materials Science (2005), the Albany Medical Center Prize in Medicine and Biomedical Research (2005), the largest prize in the U.S. for medical research, induction into the National Inventors Hall of Fame (2006), the Max Planck Research Award (2008), the Prince of Asturias Award for Technical and Scientific Research (2008), the Warren Alpert Foundation Prize (2011) and the Terumo International Prize (2012). In 1998, he received the Lemelson-MIT prize, the world’s largest prize for invention for being “one of history’s most prolific inventors in medicine.” In 1989 Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences, and in 2012 he was elected to the National Academy of Inventors.

Forbes Magazine (1999) and Bio World (1990) have named Dr. Langer as one of the 25 most important individuals in biotechnology in the world. Discover Magazine (2002) named him as one of the 20 most important people in this area. Forbes Magazine (2002) selected Dr. Langer as one of the 15 innovators world wide who will reinvent our future. Time Magazine and CNN (2001) named Dr. Langer as one of the 100 most important people in America and one of the 18 top people in science or medicine in America (America’s Best). Parade Magazine (2004) selected Dr. Langer as one of 6 “Heroes whose research may save your life.” Dr. Langer has received honorary doctorates from Harvard University, the Mt. Sinai School of Medicine, Yale University, Western University (Canada), the ETH (Switzerland), the Technion (Israel), the Hebrew University of Jerusalem (Israel), the Universite Catholique de Louvain (Belgium), Rensselaer Polytechnic Institute, Willamette University, the University of Liverpool (England), Bates College, the University of Nottingham (England), Albany Medical College, Pennsylvania State University, Northwestern University, Uppsala University (Sweden), Tel Aviv University (Israel), Boston University, Ben Gurion University (Israel), Drexel University and the University of California – San Francisco Medal. He received his Bachelor’s Degree from Cornell University in 1970 and his Sc.D. from the Massachusetts Institute of Technology in 1974, both in Chemical Engineering. - See more at: http://www.oxbridgebiotech.com/events/biotech-boom-can-learn-banner-year/#sthash.B4F2WfTJ.dpuf
Robert S. Langer is the David H. Koch Institute Professor (there are 11 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member). Dr. Langer has written over 1,250 articles. He also has nearly 1,050 patents worldwide. Dr. Langer’s patents have been licensed or sublicensed to over 250 pharmaceutical, chemical, biotechnology and medical device companies. He is the most cited engineer in history.

He served as a member of the United States Food and Drug Administration’s SCIENCE Board, the FDA’s highest advisory board, from 1995 -- 2002 and as its Chairman from 1999-2002.

Dr. Langer has received over 220 major awards. He is one of 7 individuals to have received both the United States National Medal of Science (2006) and the United States National Medal of Technology and Innovation (2011). He also received the 2002 Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineers, the 2008 Millennium Prize, the world’s largest technology prize, the 2012 Priestley Medal, the highest award of the American Chemical Society, the 2013 Wolf Prize in Chemistry and the 2014 Breakthrough Prize in Life Sciences. He is the also the only engineer to receive the Gairdner Foundation International Award; 82 recipients of this award have subsequently received a Nobel Prize. Among numerous other awards Langer has received are the Dickson Prize for Science (2002), Heinz Award for Technology, Economy and Employment (2003), the Harvey Prize (2003), the John Fritz Award (2003) (given previously to inventors such as Thomas Edison and Orville Wright), the General Motors Kettering Prize for Cancer Research (2004), the Dan David Prize in Materials Science (2005), the Albany Medical Center Prize in Medicine and Biomedical Research (2005), the largest prize in the U.S. for medical research, induction into the National Inventors Hall of Fame (2006), the Max Planck Research Award (2008), the Prince of Asturias Award for Technical and Scientific Research (2008), the Warren Alpert Foundation Prize (2011) and the Terumo International Prize (2012). In 1998, he received the Lemelson-MIT prize, the world’s largest prize for invention for being “one of history’s most prolific inventors in medicine.” In 1989 Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences, and in 2012 he was elected to the National Academy of Inventors.

Forbes Magazine (1999) and Bio World (1990) have named Dr. Langer as one of the 25 most important individuals in biotechnology in the world. Discover Magazine (2002) named him as one of the 20 most important people in this area. Forbes Magazine (2002) selected Dr. Langer as one of the 15 innovators world wide who will reinvent our future. Time Magazine and CNN (2001) named Dr. Langer as one of the 100 most important people in America and one of the 18 top people in science or medicine in America (America’s Best). Parade Magazine (2004) selected Dr. Langer as one of 6 “Heroes whose research may save your life.” Dr. Langer has received honorary doctorates from Harvard University, the Mt. Sinai School of Medicine, Yale University, Western University (Canada), the ETH (Switzerland), the Technion (Israel), the Hebrew University of Jerusalem (Israel), the Universite Catholique de Louvain (Belgium), Rensselaer Polytechnic Institute, Willamette University, the University of Liverpool (England), Bates College, the University of Nottingham (England), Albany Medical College, Pennsylvania State University, Northwestern University, Uppsala University (Sweden), Tel Aviv University (Israel), Boston University, Ben Gurion University (Israel), Drexel University and the University of California – San Francisco Medal. He received his Bachelor’s Degree from Cornell University in 1970 and his Sc.D. from the Massachusetts Institute of Technology in 1974, both in Chemical Engineering. - See more at: http://www.oxbridgebiotech.com/events/biotech-boom-can-learn-banner-year/#sthash.B4F2WfTJ.dpuf

Contact Information

Robert S. Langer

room 76-661
phone (617) 253-3107
email rlanger@mit.edu

Langer Lab

phone (617) 253-3123
fax (617) 258-8827
website

Administrative Assistant:

Laura White
phone (617) 253-3123
email langeraa@mit.edu