What makes cancer cells different, and dangerous? Among the myriad genetic alterations observed in tumors, only some propel cancer cells to proliferate abnormally, survive inappropriately and resist the drugs administered to destroy them. Furthermore, every cancer is different, as multiple pathways can lead to the same lethal conclusion. To know which alterations represent important therapeutic targets, we need to understand their place in the vast molecular network that underpins cellular function. We are using multiple genomic, proteomic, computational, and in vivo approaches to build a comprehensive “wiring diagram” for cancer cells and their molecular environment. This blueprint will lead us to better, more sophisticated strategies to control individual cancers and combat drug resistance.
Featured Faculty: Matthew Vander Heiden
Learn more about the Vander Heiden lab and their efforts to better understand cancer cell metabolism and how small molecules might be used to activate enzymes and restore the normal state of cells.
Participating Intramural Faculty
To browse recent publications by these and other Koch Institute faculty members, visit Progress, our monthly research review.