Contact Information

J. Christopher Love

room 76-253
phone (617) 324-2300
email clove@mit.edu

Love Lab

phone (617) 324-5295
fax (617) 258-5042
website

Administrative Assistant:

Mariann Murray
room 76-261
phone (617) 253-0632
email mariann@mit.edu

Related Items

J. Christopher Love

J. Christopher Love

Associate Professor of Chemical Engineering

Associate Member, Broad Institute

Associate Member, Ragon Institute of MGH, MIT and Harvard

Ph.D. 2004, Harvard University

 

KI Research Areas of Focus:
Nano-based DrugsPersonalized Medicine
,
Cancer Immunology

"Our interdisciplinary, team-oriented research combines principles from chemical engineering, interfacial chemistry, and materials science to develop new micro- and nanotechnologies for addressing biological questions in immunology, microbiology, systems biology, and bioprocess engineering. One broad research objective is to improve the design and implementation of quantitative bioanalytical processes in order to maximize the knowledge gained about the heterogeneities and dynamics of individual cells within a complex population. We employ these processes to characterize the pathogenesis and immunomodulation of complex immune responses in chronic human diseases, such as HIV/AIDS, multiple sclerosis, Type 1 diabetes, food allergies, and cancer."

Learn more about how the Love lab is using miniature micro titer plates and micro fluidics to evaluate populations of cells, maximize their productivity, and ultimately improve the process for developing cancer biologics by watching this video: "Inside the Lab: J. Christopher Love, Ph.D."

J. Christopher Love is an Associate Professor of Chemical Engineering at the Koch Institute for Integrative Cancer Research at MIT.  He is also an Associate Member of the Broad Institute, and an Associate Member at the Ragon Institute of MGH, MIT, and Harvard. Love earned a B.S. in chemistry from the University of Virginia and a Ph.D. in physical chemistry at Harvard University under the supervision of George Whitesides. Following completion of his doctoral studies, he extended his research into immunology at Harvard Medical School with Hidde Ploegh from 2004-2005, and at the Immune Disease Institute from 2005-2007. Dr. Love was a W.M. Keck Distinguished Young Scholar for Medical Research and a Dana Scholar for Human Immunology in 2009, a Life Sciences Research Foundation Postdoc Fellow (Gilead Sciences) in 2004, and a National Defense Science and Engineering Graduate Fellow from 1999-2002. He was also awarded the Foresight Distinguished Student Award in Nanotechnology in 2000. Love is also a Camille Dreyfus Teacher-Scholar.

Further Information

Research Summary

Love and the team of interdisciplinary researchers in his lab combine principles from chemical engineering, interfacial chemistry, and materials science to develop new micro- and nanotechnologies for addressing biological questions in immunology, microbiology, systems biology, and bioprocess engineering. One broad research objective is to improve the design and implementation of quantitative bioanalytical processes in order to maximize the knowledge gained about the heterogeneities and dynamics of individual cells within a complex population. The researchers employ these processes to characterize the pathogenesis and immunomodulation of complex immune responses in chronic human diseases, such as HIV/AIDS, multiple sclerosis, Type 1 diabetes, food allergies, and cancer.  A second objective is to develop new strategies for manufacturing biologic drugs to improve global access for patients.

Selected Publications

Love, J.C. Integrated process design for single-cell analytical technologies. AIChE J. 56, 2496-2502 (2010).

Gong, Y., Ogunniyi, A.O. & Love, J.C. Massively parallel detection of gene expression in single cells using subnanoliter wells. Lab Chip 10, 2334-2337 (2010).

Love, K.R., Panagiotou, V., Jiang, B., Stadheim, T.A. & Love, J.C. Integrated single-cell analysis shows Pichia pastoris secretes protein stochastically. Biotechnol. Bioeng. 106 (2), 319-325 (2010).

Han, Q., Bradshaw, E.M., Nilsson, B., Hafler, D.A. & Love, J.C. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip 10, 1391-1400 (2010).

Ogunniyi, A. O., Story, C.M., Papa, E., Guillen, E., & Love, J.C. Screening individual hybridomas by microengraving to discover monoclonal antibodies. Nature Protocols 4, 767-782 (2009).

Story, C. M., Papa, E., Hu, C.-C. A., Ronan, J. L., Ploegh, H. L. & Love, J. C. Profiling antibody responses by multiparametric analysis of single B cells. Proc. Natl. Acad. Sci. U. S. A. 105, 17902-17907 (2008).

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