Jacqueline A. Lees

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Lees & Weinberg Tackle Unanswered Questions

Jacqueline Lees, associate director of the Koch Institute and professor of biology, and Robert Weinberg, Daniel K. Ludwig Professor for Cancer Research and director of the KI’s Ludwig Center for Molecular Oncology, each tackled a still-unanswered question about cancer biology in the July issue of Scientific American. Lees weighs in on the potential role of inflammation after cancer treatment and surgery in waking up dormant cancer cells, which in turn could interact with nearby normal cells and restart a tumor. According to Lees, the right sequence of drugs could suppress this interaction. When it comes to understanding the mechanisms underlying the metastasis process, Weinberg points out that how cancer cells adapt and survive in a new tissue after leaving the primary tumor site remains unknown. He hypothesizes that this process results from significant changes in gene expression. Inquiries like these help spark the bold new cancer treatment approaches in development at the KI. more...

Role of Bmi1 in Intestinal Development and Tumorigenesis

Jacqueline Lees, Koch Institute, Massachusetts Institute of Technology watch...

Inside the Lab: Jacqueline Lees

Jacqueline Lees

Learn more about the work that Professor Lees and her lab are doing to understand how proteins and pathways are mutated in cancer – and how they hope to make advances in detecting and hopefully treating osteosarcoma. watch...