Daniel G. Anderson

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The KI at The Leading-edge of Nanomedicine

The nanotechnology-based drug delivery systems being developed at the KI are a revolutionary gateway to new, more targeted disease treatments. An  MIT News article published on March 11 nicely featured the exciting work of KI members Dan Anderson, Paula Hammond, Michael Cima, and Robert Langer, who are engineering new nanoscale therapeutic agents that selectively target and destroy cancer cells or help monitor tumor response to treatment. “We’re doing this because we can do some cool technology, but more importantly, we’re doing it because there’s a clinically meaningful need,” says Cima.

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Nucleic Acid Origami Improves Therapeutic RNA Delivery to Cancer Tumors

KI researchers have built tiny particles made out of DNA and RNA that can deliver snippets of RNA directly to tumors, turning off genes expressed in cancer cells. The particles' composition, together with their specialized construction, poses less risk of side effects and allows for better targeting. This research is reported in the June 3rd edition of Nature Nanotechnology. more...

Cancer Drug Therapy Direct to Tumor

KI researchers devised new nanoparticles that, triggered by UV light, can synthesize proteins to fight cancer cells once they reach the tumor site. The proteins battle the cancer cells while avoiding healthy cells, reducing side effects of treatment. The research appears in the journal NanoLetters. more...

RNA Interference Inhibits Inflammation

Collaborative effort, including KI researchers, successfully delivered short strands of RNA to reduce inflammation. The findings are reported in the October 9, 2011 issue of Nature Biotechnology and could eventually lead to treatments for cancer and heart patients. more...

Nanoparticle Drug Delivery Improved

KI and Alnylam Pharmaceuticals researchers collaborated to find a new nanoparticle that successfully delivered siRNA therapeutics into cells. The researchers tested over 1,500 diverse nanoparticles to deliver the drugs. The research paper appears in this week’s issue of Proceedings of the National Academy of Sciences (PNAS). more...

Inside the Lab: Daniel Anderson

Daniel Anderson

Learn more about the work that Professor Anderson’s lab is doing to create tiny nanoparticles that can deliver RNA to a cancer cell to stop tumor growth. watch...

Biodegradable polymer (Image: Jordan Green)

Nanoparticles for gene therapy improve

About five years ago, Professor Janet Sawicki at the Lankenau Institute in Pennsylvania read an article about nanoparticles developed by MIT's Daniel Anderson and Robert Langer for gene therapy, the insertion of genes into living cells for the treatment of disease. The resulting cross-institutional collaboration has led to a promising ovarian cancer formulation. more...

Using RNAi to tackle ovarian cancer

Small RNA molecules can effectively keep ovarian tumors from growing and spreading in mice, according to a team of researchers from MIT, the Lankenau Institute for Medical Research and Alnylam Pharmaceuticals. more...

Team develops safe, effective RNA interference technique

A team of researchers from MIT and Alnylam Pharmaceuticals has developed safe and effective methods to perform RNA interference, a therapy that holds great promise for treating a variety of diseases including cancer and hepatitis. more...

Massachusetts Institute of Technology