The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Preclinical Modeling, Imaging & Testing

Welcome to the Preclinical Modeling, Imaging & Testing Core (PMIT) at the Koch Institute. The Core’s mission is to navigate and streamline the path from the development of new therapeutic, diagnostic and basic discovery biomedical tools at the bench to their evaluation within a valid biological system. The PMIT Core combines the expertise and instrumentation to facilitate the generation and high-resolution characterization of disease models, to assist investigations of the mechanisms of disease development, to enable the evaluations of drug efficacy and resistance, and to provide the means for testing novel strategies and devices for disease detection and drug delivery.

The facilities of the core work very closely together to accelerate translation of laboratory discoveries toward clinical implementation for patients.

Preclinical Modeling Facility Preclinical Imaging & Testing Facility

Generate custom mouse models of disease including mice that contain the same mutations found in patients

  • CRISPR editing
  • Gene Targeting
  • Transgenics

Develop and optimize animal replacement technologies such as specialized culture of stems cells, organoids and primary cell lines

Develop and optimize animal replacement technologies such as specialized culture of stems cells, organoids and primary cell lines

Initiate orthotopic, subcutaneous or syngenic tumors in rodents

Multimodality imaging

  • Positron Emission Tomography
  • Magnetic Resonance Imaging
  • Micro-Computerized Tomography
  • Fluorescence and Bioluminescence Imaging
  • Ultrasound Imaging
  • Photoacoustic Imaging

Generation of preclinical imaging endpoints informed by testing data

Integration of advanced imaging computation with predictive features

Pilot and preclinical studies in cells and small vertebrates to gain pharmacokinetic and pharmacodynamic information about new drugs, delivery systems or devices

 

 

 

 

Facility Sponsors