Preclinical Modeling, Imaging & Testing
Welcome to the Preclinical Modeling, Imaging & Testing Core (PMIT) at the Koch Institute. The Core’s mission is to navigate and streamline the path from the development of new therapeutic, diagnostic and basic discovery biomedical tools at the bench to their evaluation within a valid biological system. The PMIT Core combines the expertise and instrumentation to facilitate the generation and high-resolution characterization of disease models, to assist investigations of the mechanisms of disease development, to enable the evaluations of drug efficacy and resistance, and to provide the means for testing novel strategies and devices for disease detection and drug delivery.
The facilities of the core work very closely together to accelerate translation of laboratory discoveries toward clinical implementation for patients.
| Preclinical Modeling Facility | Preclinical Imaging & Testing Facility |
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Generate custom mouse models of disease including mice that contain the same mutations found in patients
Develop and optimize animal replacement technologies such as specialized culture of stems cells, organoids and primary cell lines Develop and optimize animal replacement technologies such as specialized culture of stems cells, organoids and primary cell lines Initiate orthotopic, subcutaneous or syngenic tumors in rodents |
Multimodality imaging
Generation of preclinical imaging endpoints informed by testing data Integration of advanced imaging computation with predictive features Pilot and preclinical studies in cells and small vertebrates to gain pharmacokinetic and pharmacodynamic information about new drugs, delivery systems or devices |
Facility Sponsors
