The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Screening Libraries

Small Molecule Libraries

The High Throughput Sciences Core currently has a collection of approximately 2700 commercially available, annotated, targeted compounds, including a comprehensive set of approved oncology therapeutics, FDA approved compounds, natural products, and epigenetics libraries. Additionally, we offer a library of 50,000 novel chemical entities (NCEs) that explores a diversity of stereochemical and structural parameters. The HTS Core has also partnered with academic chemistry research groups that have provided preliminary screening decks and opportunity for collaboration, including chemistry follow-up.

Genomic Perturbation Libraries

  • Lentiviral shRNA library targeting 2600 human genes, addressing oncology- relevant targets and pathways
  • 3 hairpins per gene, each with documented potent knockdown activity
  • CRISPR sgRNA library for all protein-coding mouse genes, ~2200 total genes
    • Divided into 48 pools based on the KEGG terms
    • 3 guides per gene

We are currently working with vendors to procure additional compounds to meet the needs of our researchers. For example, we plan to acquire a similar CRISPR sgRNA library for human genes. For the most up-to-date library information, please contact Jaime Cheah.