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The High Throughput Sciences Core currently has a collection of approximately 2700 commercially available, annotated, targeted compounds, including a comprehensive set of approved oncology therapeutics, FDA approved compounds, natural products, and epigenetics libraries. Additionally, we offer a library of 50,000 novel chemical entities (NCEs) that explores a diversity of stereochemical and structural parameters. The HTS Core has also partnered with academic chemistry research groups that have provided preliminary screening decks and opportunity for collaboration, including chemistry follow-up.
We are currently working with vendors to procure additional compounds to meet the needs of our researchers. For example, we plan to acquire a similar CRISPR sgRNA library for human genes. For the most up-to-date library information, please contact Jaime Cheah.