The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Instrumentation

In-vivo instrumentation (imaging)

Ex-vivo instrumentation (non-imaging)

IVIS Spectrum bioluminescent and fluorescent imaging systems (Perkin Elmer)

 

Our two IVIS Spectrum instruments can perform both fluorescence and bioluminescence imaging. Typical applications include qualitative tumor burden tracking, high throughput in vivo and ex-vivo biodistribution and screening studies.

Typical features include:

Imaging throughput Up to 5 mice or 2 rats per imaging session
Heating Yes, heated platform
Physiological monitoring No
Acquisition type 2D (3D through surface topography)
Typical acquisition times 1 sec - 1 min
Nominal spatial resolution ex-vivo: 20 um, in-vivo: mm depending on depth in tissue
Max field of view 23 cm x 23 cm
Analysis software Living Image


For the system specifications click here

For the acquisition software manual click here


Skyscan 1276 animal and specimen x-ray microtomograph (Bruker)

Our microCT instrument can perform high resolution x-ray tomography and is typically used for bone structure imaging, lung tumor imaging, implant tracking as well as contrast enhanced vascular imaging

Typical features include:

Imaging throughput Up to 4 mice or 1 rat, multiple specimens per imaging session
Heating Yes, heated airflow
Physiological monitoring Yes (ECG, breathing, temperature)
Acquisition type 2D, 3D, 4D, helical
Typical acquisition times 1-40 mins
Nominal spatial resolution ex-vivo: 5 um, in-vivo: 20 um
Max field of view Continuously adjustable (specimen-mouse-primate)
Analysis software CTan, CTVol


 


Vevo 3100 and LAZR-X ultrasound and photoacoustic imaging system (FujiFilm-VisualSonics)

Our ultrasound system is equipped with four transducers with frequencies from 18 to 70 MHz ideal for imaging of a wide variety of species from zebrafish to primates. Typical applications include blood flow and capillary perfusion measurements, cardiac imaging, tumor imaging, needle guidance and implant imaging.

Our photoacoustic system is equipped with a multi-wavelength pulsed laser source (680-970 nm and 1200-2000nm) that allows for spectral characterization of compounds such as gold and carbon nanostructures, as well as oxygen saturation measurements in blood.

Typical features include:

Imaging throughput 1 mice or rat per imaging session
Heating Yes, heated platform
Physiological monitoring Yes (ECG, breathing, temperature)
Acquisition type 2D, 3D, 4D
Typical acquisition times real time - 5 mins (for 3D)
Nominal spatial resolution 30 um@70 MHz to 100 um@18 MHz
Max field of view 9.7 mm x 12 mm @ 70 MHz to 23 mm x 36 mm @18 MHz
Analysis software VevoLab


 


Varian (magnet) / Bruker (console) 7T MRI system (A2B Bruker upgrade)

Imaging throughput 1 mice or rat per imaging session
Heating Yes, heated airflow
Physiological monitoring Yes (ECG, breathing, temperature)
Acquisition type 2D, 3D
Typical acquisition times 2-30 mins
Nominal spatial resolution 150 um
Max field of view 40 mm
Analysis software ParaVision


 


G8 PET/CT preclinical imaging system (Perkin Elmer)

Our PET system is capable of highly sensitive tumor detection and biodistribution and therapeutic targeting studies using radioisotopes such as 18F, 64Cu, 89Zr.  It is limited to full body mouse and rat head due to the small bore which allows for superb sensitivity comparatively to other PET machines. The system also includes a CT scanner that allows for co-registration of the PET image with the anatomy of the animal.

Typical features include:

Imaging throughput 1 mouse or one rat brain per imaging session
Heating Yes
Physiological monitoring No
Acquisition type 2D, 3D
Typical acquisition times 10 mins (PET) 5 mins (CT)
Nominal spatial resolution 1.4 mm at the center of field of view
Max field of view 4.7 cm x 9.5 cm
Analysis software VivoQuant


For the system specifications click here


2480 Wizard2 automatic gamma counter (Perkin Elmer)

Our gamma counter is well suited for quantitative measurements of PET tracer and a large library of gamma emitting radionuclides in excised tissues and comparison with image-based PET biodistribution data.

Typical features include:
 

Imaging throughput 1000 samples per run
Acquisition  counts
Physiological monitoring library of 51 radionuclides
Sample volume 3-20 ml
Energy window 15-2000 keV
Analysis software StatLIA


For the system specifications click here