The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: August 2020

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1. Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz OH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB. Nat Commun. pubmed:32807787;  doi:10.1038/s41467-020-17958-z

2. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Fahed AC, Wang M, Homburger JR, Patel AP, Bick AG, Neben CL, Lai C, Brockman D, Philippakis A, Ellinor PT, Cassa CA, Lebo M, Ng K, Lander ES, Zhou AY, Kathiresan S, Khera AV. Nat Commun. pubmed:32820175;  doi:10.1038/s41467-020-17374-3

3. Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity. Begg BE, Jens M, Wang PY, Minor CM, Burge CB. Nat Struct Mol Biol. pubmed:32807990;  doi:10.1038/s41594-020-0475-8

4. Nicotinamide riboside with pterostilbene (NRPT) increases NAD(+) in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI. Simic P, Vela Parada XF, Parikh SM, Dellinger R, Guarente LP, Rhee EP. BMC Nephrol. pubmed:32791973;  doi:10.1186/s12882-020-02006-1

5. The network effect: studying COVID-19 pathology with the Human Cell Atlas. Teichmann S, Regev A. Nat Rev Mol Cell Biol. pubmed:32606379;  doi:10.1038/s41580-020-0267-3

6. Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. McFarland JM, Paolella BR, Warren A, Geiger-Schuller K, Shibue T, Rothberg M, Kuksenko O, Colgan WN, Jones A, Chambers E, Dionne D, Bender S, Wolpin BM, Ghandi M, Tirosh I, Rozenblatt-Rosen O, Roth JA, Golub TR, Regev A, Aguirre AJ, Vazquez F, Tsherniak A. Nat Commun. pubmed:32855387;  doi:10.1038/s41467-020-17440-w

7. A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest. Tsabar M, Mock CS, Venkatachalam V, Reyes J, Karhohs KW, Oliver TG, Regev A, Jambhekar A, Lahav G. Cell Rep. pubmed:32755587;  doi:10.1016/j.celrep.2020.107995

8. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage. Lam FC, Kong YW, Huang Q, Vu Han TL, Maffa AD, Kasper EM, Yaffe MB. Nat Commun. pubmed:32796829;  doi:10.1038/s41467-020-17503-y

9. Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression. Krismer K, Bird MA, Varmeh S, Handly ED, Gattinger A, Bernwinkler T, Anderson DA, Heinzel A, Joughin BA, Kong YW, Cannell IG, Yaffe MB. Cell Rep. pubmed:32846122;  doi:N/A

10. alphaV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Catignas KK, Frick LR, Pellegatta M, Hurley E, Kolb Z, Addabbo K, McCarty JH, Hynes RO, van der Flier A, Poitelon Y, Wrabetz L, Laura Feltri M. Glia. pubmed:32744761;  doi:N/A

11. Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D, Getz G, Boland GM, Chen F, Buenrostro JD, Hacohen N, Wu CJ, Aryee MJ, Regev A, Sankaran VG. Nat Biotechnol. pubmed:32788668;  doi:N/A

12. A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood. Sangesland M, Yousif AS, Ronsard L, Kazer SW, Zhu AL, Gatter GJ, Hayward MR, Barnes RM, Quirindongo-Crespo M, Rohrer D, Lonberg N, Kwon D, Shalek AK, Lingwood D. Cell Rep. pubmed:32846123;  doi:10.1016/j.celrep.2020.108065

13. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. Arterioscler Thromb Vasc Biol. pubmed:32460581;  doi:10.1161/ATVBAHA.118.314087

14. An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease. Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA. Sci Signal. pubmed:32753478;  doi:10.1126/scisignal.aay3258

15. A platform for multiplexed colorimetric microRNA detection using shape-encoded hydrogel particles. Juthani N, Doyle PS. Analyst. pubmed:32567641;  doi:10.1039/d0an00938e

16. Ingestible transiently anchoring electronics for microstimulation and conductive signaling. Abramson A, Dellal D, Kong YL, Zhou J, Gao Y, Collins J, Tamang S, Wainer J, McManus R, Hayward A, Frederiksen MR, Water JJ, Jensen B, Roxhed N, Langer R, Traverso G. Sci Adv. pubmed:32923616;  doi:10.1126/sciadv.aaz0127

17. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Lu X, Miao L, Gao W, Chen Z, McHugh KJ, Sun Y, Tochka Z, Tomasic S, Sadtler K, Hyacinthe A, Huang Y, Graf T, Hu Q, Sarmadi M, Langer R, Anderson DG, Jaklenec A. Sci Transl Med. pubmed:32801144;  doi:N/A

18. Dissecting the antibody-OME: past, present, and future. Loos C, Lauffenburger DA, Alter G. Curr Opin Immunol. pubmed:32755751;  doi:N/A

19. A scalable approach to determine intracardiac pressure from mechanical circulatory support device signals. Chang BY, Moyer C, El Katerji A, Keller SP, Edelman ER. IEEE Trans Biomed Eng. pubmed:32784129;  doi:N/A