The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: July 2019

Return to Progress index

1. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Zivna M, Baresova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A. Cell. pubmed:31348885;  doi:10.1016/j.cell.2019.07.002

2. Increased PHGDH expression promotes aberrant melanin accumulation. Mattaini KR, Sullivan MR, Lau AN, Fiske BP, Bronson RT, Vander Heiden MG. BMC Cancer. pubmed:31331318;  doi:10.1186/s12885-019-5933-5

3. Nuclei multiplexing with barcoded antibodies for single-nucleus genomics. Gaublomme JT, Li B, McCabe C, Knecht A, Yang Y, Drokhlyansky E, Van Wittenberghe N, Waldman J, Dionne D, Nguyen L, De Jager PL, Yeung B, Zhao X, Habib N, Rozenblatt-Rosen O, Regev A. Nat Commun. pubmed:31266958;  doi:10.1038/s41467-019-10756-2

4. Conservation, acquisition, and functional impact of sex-biased gene expression in mammals. Naqvi S, Godfrey AK, Hughes JF, Goodheart ML, Mitchell RN, Page DC. Science. pubmed:31320509;  doi:10.1126/science.aaw7317

5. Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. Hu G, Dong T, Wang S, Jing H, Chen J. EBioMedicine. pubmed:31278070;  doi:10.1016/j.ebiom.2019.06.039

6. Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A. Cell. pubmed:31348891;  doi:10.1016/j.cell.2019.06.029

7. Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice. Tang X, Drotar J, Li K, Clairmont CD, Brumm AS, Sullins AJ, Wu H, Liu XS, Wang J, Gray NS, Sur M, Jaenisch R. Sci Transl Med. pubmed:31366578;  doi:10.1126/scitranslmed.aau0164

8. Whsc1 links pluripotency exit with mesendoderm specification. Tian TV, Di Stefano B, Stik G, Vila-Casadesus M, Sardina JL, Vidal E, Dasti A, Segura-Morales C, De Andres-Aguayo L, Gomez A, Goldmann J, Jaenisch R, Graf T. Nat Cell Biol. pubmed:31235934;  doi:10.1038/s41556-019-0342-1

9. C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly. Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini DM, Gozzo FC, Aparicio R, Smetana JHC. FEBS Open Bio. pubmed:31314152;  doi:10.1002/2211-5463.12700

10. A unifying review of polymer networks: from rubbers and gels to porous frameworks. Gu Y, Zhao J, Johnson JA. Angew Chem Int Ed Engl. pubmed:31310443;  doi:10.1002/anie.201902900

11. Fluid assessment in dialysis patients by point-of-care magnetic relaxometry. Colucci LA, Corapi KM, Li M, Parada XV, Allegretti AS, Lin HY, Ausiello DA, Rosen MS, Cima MJ. Sci Transl Med. pubmed:31341060;  doi:10.1126/scitranslmed.aau1749

12. Antimalarial activity of primaquine operates via a two-step biochemical relay. Camarda G, Jirawatcharadech P, Priestley RS, Saif A, March S, Wong MHL, Leung S, Miller AB, Baker DA, Alano P, Paine MJI, Bhatia SN, O'Neill PM, Ward SA, Biagini GA. Nat Commun. pubmed:31324806;  doi:10.1038/s41467-019-11239-0

13. Silencing cortical activity during sound-localization training impairs auditory perceptual learning. Bajo VM, Nodal FR, Korn C, Constantinescu AO, Mann EO, Boyden ES3rd, King AJ. Nat Commun. pubmed:31300665;  doi:10.1038/s41467-019-10770-4

14. Analyzing Learned Molecular Representations for Property Prediction. Yang K, Swanson K, Jin W, Coley CW, Eiden P, Gao H, Guzman-Perez A, Hopper T, Kelley B, Mathea M, Palmer A, Settels V, Jaakkola TS, Jensen KF, Barzilay R. J Chem Inf Model. pubmed:31361484;  doi:10.1021/acs.jcim.9b00237

15. Advances in the automation of whole-cell patch clamp technology. Suk HJ, Boyden ES, van Welie I. J Neurosci Methods. pubmed:31336060;  doi:10.1016/j.jneumeth.2019.108357

16. Biohybrid Design Gets Personal: New Materials for Patient-Specific Therapy. Raman R, Langer R. Adv Mater. pubmed:31271257;  doi:10.1002/adma.201901969

17. Do Neural Information Extraction Algorithms Generalize Across Institutions?. Santus E, Li C, Yala A, Peck D, Soomro R, Faridi N, Mamshad I, Tang R, Lanahan CR, Barzilay R, Hughes K. JCO Clin Cancer Inform. pubmed:31310566;  doi:10.1200/CCI.18.00160

18. A systems biology pipeline identifies regulatory networks for stem cell engineering. Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. Nat Biotechnol. pubmed:31267104;  doi:10.1038/s41587-019-0159-2

19. Fatty Acid Metabolites Combine with Reduced beta Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR4th, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Cell Metab. pubmed:31378464;  doi:10.1016/j.cmet.2019.07.004

20. Colloidal Gelation through Thermally Triggered Surfactant Displacement. Cheng LC, Sherman ZM, Swan JW, Doyle PS. Langmuir. pubmed:31298032;  doi:10.1021/acs.langmuir.9b00596

21. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O'Fallon P, Fuimaono K, Edelman ER. Hypertension. pubmed:31303108;  doi:10.1161/HYPERTENSIONAHA.119.12918

22. Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination. Boopathy AV, Mandal A, Kulp DW, Menis S, Bennett NR, Watkins HC, Wang W, Martin JT, Thai NT, He Y, Schief WR, Hammond PT, Irvine DJ. Proc Natl Acad Sci U S A. pubmed:31358641;  doi:10.1073/pnas.1902179116