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The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: November 2019

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1. Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge 2018" (28-29 November, 2018, Naples, Italy). Ascierto PA, Bifulco C, Buonaguro L, Emens LA, Ferris RL, Fox BA, Delgoffe GM, Galon J, Gridelli C, Merlano M, Nathan P, Odunsi K, Okada H, Paulos CM, Pignata S, Schalper KA, Spranger S, Tortora G, Zarour H, Butterfield LH, Puzanov I. J Immunother Cancer. pubmed:31783779;  doi:10.1186/s40425-019-0798-3

2. A framework for examining how diet impacts tumour metabolism. Lien EC, Vander Heiden MG. Nat Rev Cancer. pubmed:31530936;  doi:10.1038/s41568-019-0198-5

3. Rare Genetic Variants Associated With Sudden Cardiac Death in Adults. Khera AV, Mason-Suares H, Brockman D, Wang M, VanDenburgh MJ, Senol-Cosar O, Patterson C, Newton-Cheh C, Zekavat SM, Pester J, Chasman DI, Kabrhel C, Jensen MK, Manson JE, Gaziano JM, Taylor KD, Sotoodehnia N, Post WS, Rich SS, Rotter JI, Lander ES, Rehm HL, Ng K, Philippakis A, Lebo M, Albert CM, Kathiresan S. J Am Coll Cardiol. pubmed:31727422;  doi:10.1016/j.jacc.2019.08.1060

4. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Subramanian A, Sidhom EH, Emani M, Vernon K, Sahakian N, Zhou Y, Kost-Alimova M, Slyper M, Waldman J, Dionne D, Nguyen LT, Weins A, Marshall JL, Rosenblatt-Rosen O, Regev A, Greka A. Nat Commun. pubmed:31784515;  doi:10.1038/s41467-019-13382-0

5. Retinoic Acid and Germ Cell Development in the Ovary and Testis. Endo T, Mikedis MM, Nicholls PK, Page DC, de Rooij DG. Biomolecules. pubmed:31771306;  doi:10.3390/biom9120775

6. Temporal release of a three-component protein subunit vaccine from polymer multilayers. Uppu DSSM, Turvey ME, Sharif ARM, Bidet K, He Y, Ho V, Tambe AD, Lescar J, Tan EY, Fink K, Chen J, Hammond PT. J Control Release. pubmed:31756392;  doi:10.1016/j.jconrel.2019.11.022

7. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma. Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlkova B, Zhang Q, Rica I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ. Crit Care Med. pubmed:31743227;  doi:10.1097/CCM.0000000000004094

8. Nutrient regulation of mTORC1 at a glance. Condon KJ, Sabatini DM. J Cell Sci. pubmed:31722960;  doi:10.1242/jcs.222570

9. Identification of DHODH as a therapeutic target in small cell lung cancer. Li L, Ng SR, Colon CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, Beytagh MC, Farago AF, Vander Heiden MG, Dyson NJ, Jacks T. Sci Transl Med. pubmed:31694929;  doi:10.1126/scitranslmed.aaw7852

10. Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM. Cell. pubmed:31704029;  doi:10.1016/j.cell.2019.10.036

11. Photoswitchable Sol-Gel Transitions and Catalysis Mediated by Polymer Networks with Coumarin-Decorated Cu24 L24 Metal-Organic Cages as Junctions. Oldenhuis NJ, Qin KP, Wang S, Ye HZ, Alt EA, Willard AP, Van Voorhis T, Craig SL, Johnson JA. Angew Chem Int Ed Engl. pubmed:31742840;  doi:10.1002/anie.201913297

12. Simultaneous profiling of gene expression and chromatin accessibility in single cells. Reyes M, Billman K, Hacohen N, Blainey PC. Adv Biosyst. pubmed:31853478;  doi:10.1002/adbi.201900065

13. A heat-stable microparticle platform for oral micronutrient delivery. Anselmo AC, Xu X, Buerkli S, Zeng Y, Tang W, McHugh KJ, Behrens AM, Rosenberg E, Duan AR, Sugarman JL, Zhuang J, Collins J, Lu X, Graf T, Tzeng SY, Rose S, Acolatse S, Nguyen TD, Le X, Guerra AS, Freed LE, Weinstock SB, Sears CB, Nikolic B, Wood L, Welkhoff PA, Oxley JD, Moretti D, Zimmermann MB, Langer R, Jaklenec A. Sci Transl Med. pubmed:31723037;  doi:10.1126/scitranslmed.aaw3680

14. Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes. Jain PK, Lo JH, Rananaware S, Downing M, Panda A, Tai M, Raghavan S, Fleming HE, Bhatia SN. Nanoscale. pubmed:31670340;  doi:10.1039/c9nr01786k

15. In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation. Smekalova EM, Gerashchenko MV, O'Connor PBF, Whittaker CA, Kauffman KJ, Fefilova AS, Zatsepin TS, Bogorad RL, Baranov PV, Langer R, Gladyshev VN, Anderson DG, Koteliansky V. Mol Ther Nucleic Acids. pubmed:31855834;  doi:10.1016/j.omtn.2019.11.009

16. Antibody Complementarity Determining Region Design Using High-Capacity Machine Learning. Liu G, Zeng H, Mueller J, Carter B, Wang Z, Schilz J, Horny G, Birnbaum ME, Ewert S, Gifford DK. Bioinformatics. pubmed:31778140;  doi:10.1093/bioinformatics/btz895

17. Murine CD8 T-cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density. Gilfillan CB, Wang C, Mohsen MO, Rufer N, Hebeisen M, Allard M, Verdeil G, Irvine DJ, Bachmann MF, Speiser DE. Eur J Immunol. pubmed:31785153;  doi:10.1002/eji.201948355

18. Localized metabolomic gradients in patient-derived xenograft models of glioblastoma. Randall EC, Lopez BGC, Peng S, Regan MS, Abdelmoula WM, Basu SS, Santagata S, Yoon H, Haigis M, Agar JN, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR. Cancer Res. pubmed:31767628;  doi:10.1158/0008-5472.CAN-19-0638

19. Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization. Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S. Cell Rep. pubmed:31722194;  doi:10.1016/j.celrep.2019.10.008

20. Designing yeast as plant-like hyperaccumulators for heavy metals. Sun GL, Reynolds EE, Belcher AM. Nat Commun. pubmed:31704944;  doi:10.1038/s41467-019-13093-6

21. Nucleic acid cleavage with a hyperthermophilic Cas9 from an uncultured Ignavibacterium. Schmidt ST, Yu FB, Blainey PC, May AP, Quake SR. Proc Natl Acad Sci U S A. pubmed:31659048;  doi:10.1073/pnas.1904273116

22. An interventional image-guided microdevice implantation and retrieval method for in-vivo drug response assessment. Bhagavatula SK, Upadhyaya K, Miller BJ, Bursch P, Lammers A, Cima MJ, Silverman SG, Jonas O. Med Phys. pubmed:31494942;  doi:10.1002/mp.13803