The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: May 2018

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1. Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation. Cohen MA, Markoulaki S, Jaenisch R. Stem Cell Reports. pubmed:29606614;  doi:10.1016/j.stemcr.2018.03.004

2. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Nat Genet. pubmed:29662165;  doi:10.1038/s41588-018-0104-1

3. Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, De Preter K, Koster J, Asgharzadeh S, Seeger RC, Wei JS, Khan J, Vandesompele J, Mestdagh P, Versteeg R, Look AT, Young RA, Iavarone A, Lasorella A, Silva JM, Maris JM, Califano A. Cancer Discov. pubmed:29510988;  doi:10.1158/2159-8290.CD-16-0861

4. A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis. Corrionero A, Horvitz HR. Curr Biol. pubmed:29731301;  doi:10.1016/j.cub.2018.03.063

5. Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway. Kritzer JA, Freyzon Y, Lindquist S. FEMS Yeast Res. pubmed:29546391;  doi:10.1093/femsyr/foy027

6. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Elife. pubmed:29745899;  doi:10.7554/eLife.36620

7. The redox requirements of proliferating mammalian cells. Hosios AM, Vander Heiden MG. J Biol Chem. pubmed:29339555;  doi:10.1074/jbc.TM117.000239

8. Understanding the tumor immune microenvironment (TIME) for effective therapy. Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. Nat Med. pubmed:29686425;  doi:10.1038/s41591-018-0014-x

9. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz OH. Cell Stem Cell. pubmed:29727683;  doi:10.1016/j.stem.2018.04.001

10. Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation. Ji Z, He L, Rotem A, Janzer A, Cheng CS, Regev A, Struhl K. Nat Commun. pubmed:29802342;  doi:10.1038/s41467-018-04406-2

11. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT. Nat Commun. pubmed:29777137;  doi:10.1038/s41467-018-04315-4

12. Could antiretrovirals be treating EBV in MS? A case report. Drosu NC, Edelman ER, Housman DE. Mult Scler Relat Disord. pubmed:29510325;  doi:10.1016/j.msard.2018.02.029

13. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB. Bioorg Med Chem. pubmed:29555419;  doi:10.1016/j.bmc.2018.02.016

14. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB. Proc Natl Acad Sci U S A. pubmed:29666270;  doi:10.1073/pnas.1722020115

15. NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM. Science. pubmed:29700228;  doi:10.1126/science.aar2663

16. Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis. Carpenter K, Bell RB, Yunus J, Amon A, Berchowitz LE. Dev Cell. pubmed:29738715;  doi:10.1016/j.devcel.2018.04.001

17. Site-Selective Cysteine-Cyclooctyne Conjugation. Zhang C, Dai P, Vinogradov AA, Gates ZP, Pentelute BL. Angew Chem Int Ed Engl. pubmed:29575377;  doi:10.1002/anie.201800860

18. Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI. Elife. pubmed:29851380;  doi:10.7554/eLife.34469

19. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Nanomaterials (Basel). pubmed:29751516;  doi:10.3390/nano8050296

20. Advances in Biomaterials for Drug Delivery. Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Adv Mater. pubmed:29736981;  doi:10.1002/adma.201705328

21. MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling. Espinosa-Diez C, Wilson R, Chatterjee N, Hudson C, Ruhl R, Hipfinger C, Helms E, Khan OF, Anderson DG, Anand S. Cell Death Dis. pubmed:29795397;  doi:10.1038/s41419-018-0690-y

22. A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Scho NA, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA. Nat Med. pubmed:29554083;  doi:10.1038/nm.4512

23. Efficient Transport Networks in a Dual Electron/Lithium-Conducting Polymeric Composite for Electrochemical Applications. McDonald M, Hammond PT. ACS Appl Mater Interfaces. pubmed:29658692;  doi:10.1021/acsami.8b01519

24. Controlling the Growth of Staphylococcus epidermidis by Layer-by-Layer Encapsulation. Jonas AM, Glinel K, Behrens A, Anselmo AC, Langer R, Jaklenec A. ACS Appl Mater Interfaces. pubmed:29693369;  doi:10.1021/acsami.8b01988

25. Design and Synthesis of Waterborne Polyurethanes. Kang SY, Ji Z, Tseng LF, Turner SA, Villanueva DA, Johnson R, Albano A, Langer R. Adv Mater. pubmed:29543353;  doi:10.1002/adma.201706237

26. Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents. McHugh KJ, Jing L, Behrens AM, Jayawardena S, Tang W, Gao M, Langer R, Jaklenec A. Adv Mater. pubmed:29468747;  doi:10.1002/adma.201706356

27. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination. Guarecuco R, Lu J, McHugh KJ, Norman JJ, Thapa LS, Lydon E, Langer R, Jaklenec A. Vaccine. pubmed:28625520;  doi:10.1016/j.vaccine.2017.05.094

28. Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513. Wong YH, Kumar A, Liew CW, Tharakaraman K, Srinivasaraghavan K, Sasisekharan R, Verma C, Lescar J. Sci Rep. pubmed:29855525;  doi:10.1038/s41598-018-26800-y

29. Engineering modular intracellular protein sensor-actuator devices. Siciliano V, DiAndreth B, Monel B, Beal J, Huh J, Clayton KL, Wroblewska L, McKeon A, Walker BD, Weiss R. Nat Commun. pubmed:29760420;  doi:10.1038/s41467-018-03984-5

30. Large-scale patterning of living colloids for dynamic studies of neutrophil-microbe interactions. Kim JJ, Reategui E, Hopke A, Jalali F, Roushan M, Doyle PS, Irimia D. Lab Chip. pubmed:29770423;  doi:10.1039/c8lc00228b

31. A multi-landing pad DNA integration platform for mammalian cell engineering. Gaidukov L, Wroblewska L, Teague B, Nelson T, Zhang X, Liu Y, Jagtap K, Mamo S, Tseng WA, Lowe A, Das J, Bandara K, Baijuraj S, Summers NM, Lu TK, Zhang L, Weiss R. Nucleic Acids Res. pubmed:29617873;  doi:10.1093/nar/gky216

32. Light sheet theta microscopy for rapid high-resolution imaging of large biological samples. Migliori B, Datta MS, Dupre C, Apak MC, Asano S, Gao R, Boyden ES, Hermanson O, Yuste R, Tomer R. BMC Biol. pubmed:29843722;  doi:10.1186/s12915-018-0521-8

33. Vessel centerline reconstruction from non-isocentric and non-orthogonal paired monoplane angiographic images. Kunio M, O'Brien CC, Lopes ACJr, Bailey L, Lemos PA, Tearney GJ, Edelman ER. Int J Cardiovasc Imaging. pubmed:29139034;  doi:10.1007/s10554-017-1275-z

34. Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope. Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R. Cell Host Microbe. pubmed:29746833;  doi:10.1016/j.chom.2018.04.004

35. Motion of Knots in DNA Stretched by Elongational Fields. Klotz AR, Soh BW, Doyle PS. Phys Rev Lett. pubmed:29775326;  doi:10.1103/PhysRevLett.120.188003

36. An ingestible bacterial-electronic system to monitor gastrointestinal health. Mimee M, Nadeau P, Hayward A, Carim S, Flanagan S, Jerger L, Collins J, McDonnell S, Swartwout R, Citorik RJ, Bulovic V, Langer R, Traverso G, Chandrakasan AP, Lu TK. Science. pubmed:29798884;  doi:10.1126/science.aas9315

37. Renal artery anatomy assessed by quantitative analysis of selective renal angiography in 1,000 patients with hypertension. Lauder L, Ewen S, Tzafriri AR, Edelman ER, Luscher TF, Blankenstijn PJ, Dorr O, Schlaich M, Sharif F, Voskuil M, Zeller T, Ukena C, Scheller B, Bohm M, Mahfoud F. EuroIntervention. pubmed:29633939;  doi:10.4244/EIJ-D-18-00112

38. Corrigendum to "Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems". Schneider C, Langer R, Loveday D, Hair D. J Control Release. pubmed:29685764;  doi:10.1016/j.jconrel.2018.04.007