The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: December 2017

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1. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG. Nat Biotechnolpubmed:29131148;  doi:10.1038/nbt.4005

2. Temporally precise single-cell-resolution optogenetics. Shemesh OA, Tanese D, Zampini V, Linghu C, Piatkevich K, Ronzitti E, Papagiakoumou E, Boyden ES, Emiliani V. Nat Neuroscipubmed:29184208;  doi:10.1038/s41593-017-0018-8

3. Topographic Pattern of Valve Calcification: A New Determinant of Disease Severity in Aortic Valve Stenosis. de Santis A, Tarasoutchi F, Araujo Filho JAB, Vieira MC, Nomura CH, Katz M, Spina GS, Sampaio RO, Accorsi TAD, Rosa VEE, Fernandes JRC, Brown J, Edelman ER, Lemos PA. JACC Cardiovasc Imagingpubmed:29248658;  doi:10.1016/j.jcmg.2017.10.006

4. Roadmap on semiconductor-cell biointerfaces. Tian B, Rogers JA, Yang P, Bao Z, Melosh NA, Gorodetsky A, Lu T, Anikeeva P, Cifra M, Cestellos-Blanco S, Carvalho-de-Souza J, Bezanilla F, Liu J, Hjort M, Cao Y, Lanzani G, Benfenati F, Galli G, Gygi F, Kautz R, Kim SS, Krivosudsky O, Havelka D, Jiang Y, Xu S. Phys Biolpubmed:29205173;  doi:10.1088/1478-3975/aa9f34

5. Liver 'organ on a chip'. Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A. Exp Cell Respubmed:29291400;  doi:10.1016/j.yexcr.2017.12.023

6. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Cancer Discovpubmed:29203461;  doi:10.1158/2159-8290.CD-17-0679

7. Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sanchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz OH. Nat Biotechnolpubmed:29220013;  doi:10.1038/nbt1217-1211a

8. Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC. Cellpubmed:29275860;  doi:10.1016/j.cell.2017.11.043

9. A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, Bouton C, Tracey KJ, Desimone R, Boyden ES, Sohal HS, Olofsson PS. J Neural Engpubmed:28628030;  doi:10.1088/1741-2552/aa7a42

10. Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy. Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, Moon J. Nano Lettpubmed:29144754;  doi:10.1021/acs.nanolett.7b03218

11. DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins. Fotoran WL, Santangelo R, de Miranda BNM, Irvine DJ, Wunderlich G. Mol Ther Methods Clin Devpubmed:28879213;  doi:10.1016/j.omtm.2017.08.004

12. Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. Shao H, Wang A, Lauffenburger D, Wells A. Int J Biochem Cell Biolpubmed:29274473;  doi:10.1016/j.biocel.2017.12.014

13. Increased expression and modulated regulatory activity of co-inhibitory receptors PD-1, TIGIT and TIM-3 in lymphocytes of systemic sclerosis patients. Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H. Arthritis Rheumatolpubmed:29245183;  doi:10.1002/art.40399

14. Temporal variation in HIV-specific IgG subclass Abs during acute infection differentiates spontaneous controllers from chronic progressors. Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith D, Little S, Lauffenburger DA, Richman D, Alter G. AIDSpubmed:29239894;  doi:10.1097/QAD.0000000000001716

15. Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. Soltis AR, Kennedy NJ, Xin X, Zhou F, Ficarro SB, Yap YS, Matthews BJ, Lauffenburger DA, White FM, Marto JA, Davis RJ, Fraenkel E. Cell Reppubmed:29241556;  doi:10.1016/j.celrep.2017.11.059

16. From Nonclinical Research to Clinical Trials and Patient-registries: Challenges and Opportunities in Biomedical Research. de la Torre Hernandez JM, Edelman ER. Rev Esp Cardiol (Engl Ed)pubmed:28838647;  doi:10.1016/j.rec.2017.07.008

17. A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non-small Cell Lung Cancer. Gu L, Deng JZ, Roy S, Hammond PT. Clin Cancer Respubmed:28912139;  doi:10.1158/1078-0432.CCR-16-2186

18. Long-term dopamine neurochemical monitoring in primates. Schwerdt HN, Shimazu H, Amemori KI, Amemori S, Tierney PL, Gibson DJ, Hong S, Yoshida T, Langer R, Cima MJ, Graybiel AM. Proc Natl Acad Sci U S Apubmed:29158415;  doi:10.1073/pnas.1713756114

19. Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery. Schoellhammer CM, Chen Y, Cleveland C, Minahan D, Bensel T, Park JY, Saxton S, Lee YL, Booth L, Langer R, Traverso G. J Control Releasepubmed:29051063;  doi:10.1016/j.jconrel.2017.10.023

20. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Stem Cell Reportspubmed:29153990;  doi:10.1016/j.stemcr.2017.10.015

21. The yeast stands alone: the future of protein biologic production. Love KR, Dalvie NC, Love JC. Curr Opin Biotechnolpubmed:29277062;  doi:10.1016/j.copbio.2017.12.010

22. Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty HE, da Costa LHA, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH. J Clin Investpubmed:29251628;  doi:10.1172/JCI95612

23. Integrated Bottom-Up and Top-Down Liquid Chromatography-Mass Spectrometry for Characterization of Recombinant Human Growth Hormone Degradation Products. Wang YA, Wu D, Auclair JR, Salisbury JP, Sarin R, Tang Y, Mozdzierz NJ, Shah K, Zhang AF, Wu SL, Agar JN, Love JC, Love KR, Hancock WS. Anal Chempubmed:29096433;  doi:10.1021/acs.analchem.7b03026

24. Neuromicrobiology: How Microbes Influence the Brain. de la Fuente-Nunez C, Meneguetti BT, Franco OL, Lu TK. ACS Chem Neuroscipubmed:29220570;  doi:10.1021/acschemneuro.7b00373

25. 3D Printing of Living Responsive Materials and Devices. Liu X, Yuk H, Lin S, Parada GA, Tang TC, Tham E, de la Fuente-Nunez C, Lu TK, Zhao X. Adv Materpubmed:29205532;  doi:10.1002/adma.201704821

26. Production of Functional Anti-Ebola Antibodies in Pichia pastoris. Purcell O, Opdensteinen P, Chen W, Lowenhaupt K, Brown A, Hermann M, Cao J, Tenhaef N, Kallweit E, Kastilan R, Sinskey AJ, Perez-Pinera P, Buyel JF, Lu TK. ACS Synth Biolpubmed:28786662;  doi:10.1021/acssynbio.7b00234

27. Tuning up T-cell receptors. Rappazzo CG, Birnbaum ME. Nat Biotechnolpubmed:29106406;  doi:10.1038/nbt.4009

28. Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice. Kolb I, Franzesi GT, Wang M, Kodandaramaiah SB, Forest CR, Boyden ES, Singer AC. J Neuroscipubmed:29279309;  doi:10.1523/JNEUROSCI.1519-17.2017

29. Expansion microscopy of zebrafish for neuroscience and developmental biology studies. Freifeld L, Odstrcil I, Forster D, Ramirez A, Gagnon JA, Randlett O, Costa EK, Asano S, Celiker OT, Gao R, Martin-Alarcon DA, Reginato P, Dick C, Chen L, Schoppik D, Engert F, Baier H, Boyden ES. Proc Natl Acad Sci U S Apubmed:29162696;  doi:10.1073/pnas.1706281114

30. SYK kinase mediates brown fat differentiation and activation. Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF. Nat Communpubmed:29235464;  doi:10.1038/s41467-017-02162-3

31. Science Forum: The Human Cell Atlas. Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Gottgens B, Hacohen N, Haniffa M, Hemberg M, Kim SK, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake SR, Reik W, Rozenblatt-Rosen O, Sanes JR, Satija R, Schumacher TN, Shalek AK, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton MR, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt FM, Weissman JS, Wold BJ, Xavier RJ, Yosef N. Elifepubmed:29206104;  doi:10.7554/eLife.27041

32. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE. Cellpubmed:29198524;  doi:10.1016/j.cell.2017.10.044

33. YY1 Is a Structural Regulator of Enhancer-Promoter Loops. Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA. Cellpubmed:29224777;  doi:10.1016/j.cell.2017.11.008

34. Mechanisms of gene regulation in human embryos and pluripotent stem cells. Theunissen TW, Jaenisch R. Developmentpubmed:29254992;  doi:10.1242/dev.157404

35. c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification. Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look AT. Cancer Discovpubmed:29284669;  doi:10.1158/2159-8290.CD-17-0993

36. The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. Pai AA, Henriques T, McCue K, Burkholder A, Adelman K, Burge CB. Elifepubmed:29280736;  doi:10.7554/eLife.32537

37. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Muller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stancakova A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njolstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jorgensen ME, Jorgensen T, Ladenvall C, Justesen JM, Karajamaki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvanen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Magi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. Sci Datapubmed:29257133;  doi:10.1038/sdata.2017.179

38. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. Sciencepubmed:29217578;  doi:10.1126/science.aal4178

39. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS. Nat Chem Biolpubmed:29251720;  doi:10.1038/nchembio.2538

40. FKBP12 contributes to alpha-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome. Caraveo G, Soste M, Cappelleti V, Fanning S, van Rossum DB, Whitesell L, Huang Y, Chung CY, Baru V, Zaichick S, Picotti P, Lindquist S. Proc Natl Acad Sci U S Apubmed:29229832;  doi:10.1073/pnas.1711926115

41. Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. McLellan CA, Vincent BM, Solis NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S. Nat Chem Biolpubmed:29227471;  doi:10.1038/nchembio.2534

42. Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin. Pinto BS, Orr-Weaver TL. Proc Natl Acad Sci U S Apubmed:29158400;  doi:10.1073/pnas.1718450114

43. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A. Neurobiol Dispubmed:29274432;  doi:10.1016/j.nbd.2017.12.010

44. EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Guen VJ, Chavarria TE, Kroger C, Ye X, Weinberg RA, Lees JA. Proc Natl Acad Sci U S Apubmed:29158396;  doi:10.1073/pnas.1711534114

45. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Reczek CR, Birsoy K, Kong H, Martinez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS. Nat Chem Biolpubmed:29058724;  doi:10.1038/nchembio.2499

46. Adaptive and reversible resistance to Kras inhibition in pancreatic cancer cells. Chen PY, Muzumdar MD, Dorans KJ, Robbins RA, Bhutkar A, Del Rosario AM, Mertins P, Qiao J, Schafer C, Gertler FB, Carr SA, Jacks T. Cancer Respubmed:29279356;  doi:10.1158/0008-5472.CAN-17-2129

47. Replication origin-flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence. Warner MD, Azmi IF, Kang S, Zhao Y, Bell SP. J Biol Chempubmed:29074622;  doi:10.1074/jbc.M117.815639

48. Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer. Qi R, Wang Y, Bruno PM, Xiao H, Yingjie Y, Li T, Lauffer S, Wei W, Chen Q, Kang X, Song H, Yang X, Huang X, Detappe A, Matulonis U, Pepin D, Hemann MT, Birrer MJ, Ghoroghchian PP. Nat Communpubmed:29255160;  doi:10.1038/s41467-017-02390-7

49. Human Neutrophil Elastase Mediates Fibrinolysis Shutdown Through Competitive Degradation of Plasminogen and Generation of Angiostatin. Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. J Trauma Acute Care Surgpubmed:28837538;  doi:10.1097/TA.0000000000001685

50. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils. Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Sciencepubmed:29191879;  doi:10.1126/science.aal5081

51. TAZ/WWTR1 mediates the pulmonary effects of NKX2-1 mutations in Brain-Lung-Thyroid syndrome. Moya CM, Zaballos MA, Garzon L, Luna C, Simon R, Yaffe MB, Gallego E, Santisteban P, Moreno JC. J Clin Endocrinol Metabpubmed:29294041;  doi:10.1210/jc.2017-01241

52. Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR. Elkins MR, Williams JK, Gelenter MD, Dai P, Kwon B, Sergeyev IV, Pentelute BL, Hong M. Proc Natl Acad Sci U S Apubmed:29158386;  doi:10.1073/pnas.1715127114