The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: September 2017

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1. Microparticle parking and isolation for highly sensitive microRNA detection. Kim JJ, Chen L, Doyle PS. Lab Chippubmed:28815227;  doi:10.1039/c7lc00653e

2. Polymer conjugated retinoids for controlled transdermal delivery. Castleberry SA, Quadir MA, Sharkh MA, Shopsowitz KE, Hammond PT. J Control Releasepubmed:28690160;  doi:10.1016/j.jconrel.2017.07.003

3. Antitumor Antibodies Can Drive Therapeutic T Cell Responses. Wittrup KD. Trends Cancerpubmed:28867165;  doi:10.1016/j.trecan.2017.07.001

4. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Sciencepubmed:28912244;  doi:10.1126/science.aah5043

5. Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections. Kwon EJ, Skalak M, Bertucci A, Braun G, Ricci F, Ruoslahti E, Sailor MJ, Bhatia SN. Adv Materpubmed:28699173;  doi:10.1002/adma.201701527

6. Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies. Tsamandouras N, Chen WLK, Edington CD, Stokes CL, Griffith LG, Cirit M. AAPS Jpubmed:28752430;  doi:10.1208/s12248-017-0122-4

7. Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition. Aday S, Zoldan J, Besnier M, Carreto L, Saif J, Fernandes R, Santos T, Bernardino L, Langer R, Emanueli C, Ferreira L. Nat Communpubmed:28963481;  doi:10.1038/s41467-017-00746-7

8. Glucose-responsive insulin by molecular and physical design. Bakh NA, Cortinas AB, Weiss MA, Langer RS, Anderson DG, Gu Z, Dutta S, Strano MS. Nat Chempubmed:28937662;  doi:10.1038/nchem.2857

9. Fabrication of fillable microparticles and other complex 3D microstructures. McHugh KJ, Nguyen TD, Linehan AR, Yang D, Behrens AM, Rose S, Tochka ZL, Tzeng SY, Norman JJ, Anselmo AC, Xu X, Tomasic S, Taylor MA, Lu J, Guarecuco R, Langer R, Jaklenec A. Sciencepubmed:28912242;  doi:10.1126/science.aaf7447

10. Multiscale technologies for treatment of ischemic cardiomyopathy. Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Nat Nanotechnolpubmed:28875984;  doi:10.1038/nnano.2017.167

11. Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems. Schneider C, Langer R, Loveday D, Hair D. J Control Releasepubmed:28789964;  doi:10.1016/j.jconrel.2017.08.004

12. Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes. Fenton OS, Kauffman KJ, Kaczmarek JC, McClellan RL, Jhunjhunwala S, Tibbitt MW, Zeng MD, Appel EA, Dorkin JR, Mir FF, Yang JH, Oberli MA, Heartlein MW, DeRosa F, Langer R, Anderson DG. Adv Materpubmed:28681930;  doi:10.1002/adma.201606944

13. A method for learning a sparse classifier in the presence of missing data for high-dimensional biological datasets. Severson KA, Monian B, Love JC, Braatz RD. Bioinformaticspubmed:28431087;  doi:10.1093/bioinformatics/btx224

14. Multiple particle tracking study of thermally-gelling nanoemulsions. Cheng LC, Hsiao LC, Doyle PS. Soft Matterpubmed:28914324;  doi:10.1039/c7sm01191a

15. Contact guidance and collective migration in the advancing epithelial monolayer. Lee G, Atia L, Lan B, Sharma Y, Nissim L, Wu MR, Pery E, Lu TK, Park CY, Butler JP, Fredberg JJ. Connect Tissue Respubmed:28945485;  doi:10.1080/03008207.2017.1384471

16. Nanoconfinement greatly speeds up the nucleation and the annealing in single-DNA collapse. Dai L, Jones JJ, Klotz AR, Levy S, Doyle PS. Soft Matterpubmed:28868564;  doi:10.1039/c7sm01249g

17. Ciprofloxacin-nitroxide hybrids with potential for biofilm control. Verderosa AD, de la Fuente-Nunez C, Mansour SC, Cao J, Lu TK, Hancock REW, Fairfull-Smith KE. Eur J Med Chempubmed:28709125;  doi:10.1016/j.ejmech.2017.06.058

18. Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration. Bachofner M, Speicher T, Bogorad RL, Muzumdar S, Derrer CP, Hurlimann F, Bohm F, Nanni P, Kockmann T, Kachaylo E, Meyer M, Padrissa-Altes S, Graf R, Anderson DG, Koteliansky V, Auf dem Keller U, Werner S. Dev Cellpubmed:28890072;  doi:10.1016/j.devcel.2017.07.025

19. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakoiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. Naturepubmed:28902842;  doi:10.1038/nature24029

20. New Insights into Genome Structure: Genes of a Feather Stick Together. Hnisz D, Young RA. Mol Cellpubmed:28886334;  doi:10.1016/j.molcel.2017.08.023

21. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6. Lee JH, Tammela T, Hofree M, Choi J, Marjanovic ND, Han S, Canner D, Wu K, Paschini M, Bhang DH, Jacks T, Regev A, Kim CF. Cellpubmed:28886383;  doi:10.1016/j.cell.2017.07.028

22. PD-L1 is an activation-independent marker of brown adipocytes. Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL. Nat Communpubmed:28935898;  doi:10.1038/s41467-017-00799-8

23. A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's Ataxia. McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM. Cell Reppubmed:28877480;  doi:10.1016/j.celrep.2017.08.051

24. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Huang NJ, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, Dong M, Shoemaker CB, Lodish HF. Nat Communpubmed:28871080;  doi:10.1038/s41467-017-00448-0

25. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF. Proc Natl Acad Sci U S Apubmed:28864529;  doi:10.1073/pnas.1711058114

26. Not just Salk. Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Sciencepubmed:28912235;  doi:10.1126/science.aao6221

27. Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism. Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. ACS Chem Neuroscipubmed:28628299;  doi:10.1021/acschemneuro.7b00187

28. Loss of native alpha-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Hum Mol Genetpubmed:28911198;  doi:10.1093/hmg/ddx227

29. Aggregation and Fibril Structure of AbetaM01-42 and Abeta1-42. Silvers R, Colvin MT, Frederick KK, Jacavone AC, Lindquist SL, Linse S, Griffin RG. Biochemistrypubmed:28792214;  doi:10.1021/acs.biochem.7b00729

30. DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression. Hua BL, Orr-Weaver TL. Geneticspubmed:28874453;  doi:10.1534/genetics.115.186627

31. Driving Rel-iant Tregs toward an Identity Crisis. Li A, Jacks T. Immunitypubmed:28930651;  doi:10.1016/j.immuni.2017.08.014

32. Targeting Metabolism for Cancer Therapy. Luengo A, Gui DY, Vander Heiden MG. Cell Chem Biolpubmed:28938091;  doi:10.1016/j.chembiol.2017.08.028

33. Intravital imaging of metastasis in adult Zebrafish. Benjamin DC, Hynes RO. BMC Cancerpubmed:28946867;  doi:10.1186/s12885-017-3647-0

34. NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis. Hofmann CL, O'Sullivan MC, Detappe A, Yu Y, Yang X, Qi W, Landon CD, Therien MJ, Dewhirst MW, Ghoroghchian PP, Palmer GM. Nanoscalepubmed:28861570;  doi:10.1039/c7nr02363dg