The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: August 2017

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1. Swimming bacteria promote dispersal of non-motile staphylococcal species. Samad T, Billings N, Birjiniuk A, Crouzier T, Doyle PS, Ribbeck K. ISME Jpubmed:28398350;  doi:10.1038/ismej.2017.23

2. Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis. Conrad C, Dorzweiler K, Miller MA, Lauffenburger DA, Strik H, Bartsch JW. Fluids Barriers CNSpubmed:28806983;  doi:10.1186/s12987-017-0070-5

3. Nano Tools Pave the Way to New Solutions in Infectious Disease. Hammond PT. ACS Infect Dispubmed:28797168;  doi:10.1021/acsinfecdis.7b00104

4. In vitro blood cell viability profiling of polymers used in molecular assembly. Jeong H, Hwang J, Lee H, Hammond PT, Choi J, Hong J. Sci Reppubmed:28842713;  doi:10.1038/s41598-017-10169-5

5. Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA. Martinez-Moreno M, O'Shea TM, Zepecki JP, Olaru A, Ness JK, Langer R, Tapinos N. Cell Reppubmed:28834756;  doi:10.1016/j.celrep.2017.07.068

6. CO2-Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology. Brown P, Sresht V, Eral BH, Fiore A, de la Fuente-Nunez C, O'Mahony M, Mendes GP, Heller WT, Doyle PS, Blankschtein D, Hatton TA. Langmuirpubmed:28699755;  doi:10.1021/acs.langmuir.7b00679

7. A novel Bxb1 integrase RMCE system for high fidelity site-specific integration of mAb expression cassette in CHO cells. Inniss MC, Bandara K, Jusiak B, Lu TK, Weiss R, Wroblewska L, Zhang L. Biotechnol Bioengpubmed:28186334;  doi:10.1002/bit.26268

8. Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. Shao H, Lauffenburger D, Wells A. Biochem Biophys Res Communpubmed:28668391;  doi:10.1016/j.bbrc.2017.06.168

9. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D. J Clin Investpubmed:28691930;  doi:10.1172/JCI93182

10. Engineering Aglycosylated IgG Variants with Wild-type or Improved Binding Affinity to Human Fc gamma RIIA and Fc gamma RIIIAs. Chen TF, Sazinsky SL, Houde D, DiLillo DJ, Bird J, Li KK, Cheng GT, Qiu H, Engen JR, Ravetch JV, Wittrup KD. J Mol Biolpubmed:28694069;  doi:10.1016/j.jmb.2017.07.001

11. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Naturepubmed:28792927;  doi:10.1038/nature23451

12. A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons. Vidaki M, Drees F, Saxena T, Lanslots E, Taliaferro MJ, Tatarakis A, Burge CB, Wang ET, Gertler FB. Neuronpubmed:28735747;  doi:10.1016/j.neuron.2017.06.048

13. Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans. Driscoll K, Stanfield GM, Droste R, Horvitz HR. Proc Natl Acad Sci U S Apubmed:28760991;  doi:10.1073/pnas.1705084114

14. The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Wolfson RL, Sabatini DM. Cell Metabpubmed:28768171;  doi:10.1016/j.cmet.2017.07.001

15. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG. Elifepubmed:28826492;  doi:10.7554/eLife.27713

16. Metabolism and Congenital Malformations - NAD's Effects on Development. Vander Heiden MG. N Engl J Medpubmed:28792881;  doi:10.1056/NEJMp1707487

17. CHARACTERIZATION OF THE EXTRACELLULAR MATRIX OF NORMAL AND DISEASED TISSUES USING PROTEOMICS. Naba A, Pearce OM, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO. J Proteome Respubmed:28675934;  doi:10.1021/acs.jproteome.7b00191

18. Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality. Takahashi N, Gruber CC, Yang JH, Liu X, Braff D, Yashaswini CN, Bhubhanil S, Furuta Y, Andreescu S, Collins JJ, Walker GC. Proc Natl Acad Sci U S Apubmed:28794281;  doi:10.1073/pnas.1707466114

19. Genome-Wide Sensitivity Analysis of the Microsymbiont Sinorhizobium meliloti to Symbiotically Important, Defensin-Like Host Peptides. Arnold MFF, Shabab M, Penterman J, Boehme KL, Griffitts JS, Walker GC. MBiopubmed:28765224;  doi:10.1128/mBio.01060-17

20. Epithelial-to-mesenchymal Transition contributes to Immunosuppression in Breast Carcinomas. Dongre A, Rashidian M, Reinhardt F, Bagnato A, Keckesova Z, Ploegh HL, Weinberg RA. Cancer Respubmed:28428275;  doi:10.1158/0008-5472.CAN-16-3292

21. Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL. J Exp Medpubmed:28666979;  doi:10.1084/jem.20161950

22. Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?. Yamanaka K, Chatterjee N, Hemann MT, Walker GC. PLoS Genetpubmed:28817566;  doi:10.1371/journal.pgen.1006842

23. A structural and mechanistic study of pi-clamp-mediated cysteine perfluoroarylation. Dai P, Williams JK, Zhang C, Welborn M, Shepherd JJ, Zhu T, Van Voorhis T, Hong M, Pentelute BL. Sci Reppubmed:28801573;  doi:10.1038/s41598-017-08402-2

24. Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions. Rojas AJ, Pentelute BL, Buchwald SL. Org Lettpubmed:28777001;  doi:10.1021/acs.orglett.7b01911