Progress: June 2017
1. Advances in the delivery of RNA therapeutics: from concept to clinical reality. Kaczmarek JC, Kowalski PS, Anderson DG. Genome Med. pubmed:28655327; doi:10.1186/s13073-017-0450-0
2. A Modular Toolkit for Generating Pichia pastoris Secretion Libraries. Obst U, Lu TK, Sieber V. ACS Synth Biol. pubmed:28252957; doi:10.1021/acssynbio.6b00337
3. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Pena A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR. Immunity. pubmed:28636956; doi:10.1016/j.immuni.2017.05.007
4. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors. Smith TT, Moffett HF, Stephan SB, Opel CF, Dumigan AG, Jiang X, Pillarisetty VG, Pillai SPS, Wittrup KD, Stephan MT. J Clin Invest. pubmed:28436934; doi:10.1172/JCI87624
5. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, Cochran JR, Wittrup KD. J Exp Med. pubmed:28473400; doi:10.1084/jem.20160831
6. On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger D, White F, Griffith L. Biomaterials. pubmed:28371736; doi:10.1016/j.biomaterials.2017.03.030
7. Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC. Mol Ther Nucleic Acids. pubmed:28624207; doi:10.1016/j.omtn.2017.04.014
8. CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W. Genome Biol. pubmed:28615073; doi:10.1186/s13059-017-1237-8
9. First-Generation Bioresorbable Vascular Scaffolds: Disappearing Stents or Disappearing Evidence?. Bangalore S, Edelman ER, Bhatt DL. J Am Coll Cardiol. pubmed:28412390; doi:10.1016/j.jacc.2017.04.012
10. A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation. Akbari S, Pirbodaghi T, Kamm RD, Hammond PT. Lab Chip. pubmed:28492663; doi:10.1039/c6lc01568a
11. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination. Guarecuco R, Lu J, McHugh KJ, Norman JJ, Thapa LS, Lydon E, Langer R, Jaklenec A. Vaccine. pubmed:28625520; doi:10.1016/j.vaccine.2017.05.094
12. Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins. Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD. Nucleic Acids Res. pubmed:28641400; doi:10.1093/nar/gkx546
13. The promise of organ and tissue preservation to transform medicine. Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM, Markmann JF, Sachs DH, Chandraker A, Wertheim JA, Rothblatt M, Boyden ES, Eidbo E, Lee WPA, Pomahac B, Brandacher G, Weinstock DM, Elliott G, Nelson D, Acker JP, Uygun K, Schmalz B, Weegman BP, Tocchio A, Fahy GM, Storey KB, Rubinsky B, Bischof J, Elliott JAW, Woodruff TK, Morris GJ, Demirci U, Brockbank KGM, Woods EJ, Ben RN, Baust JG, Gao D, Fuller B, Rabin Y, Kravitz DC, Taylor MJ, Toner M. Nat Biotechnol. pubmed:28591112; doi:10.1038/nbt.3889
14. Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Ragelle H, Naba A, Larson BL, Zhou F, Prijic M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG. Biomaterials. pubmed:28327460; doi:10.1016/j.biomaterials.2017.03.008
15. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Nat Mater. pubmed:28319612; doi:10.1038/nmat4866
16. AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures. Raguram A, Sasisekharan V, Sasisekharan R. Trends Microbiol. pubmed:28094093; doi:10.1016/j.tim.2016.12.007
17. Open-source, community-driven microfluidics with Metafluidics. Kong DS, Thorsen TA, Babb J, Wick ST, Gam JJ, Weiss R, Carr PA. Nat Biotechnol. pubmed:28591125; doi:10.1038/nbt.3873
18. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sanchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz OH. Nat Biotechnol. pubmed:28459449; doi:10.1038/nbt.3836
19. Ciprofloxacin-nitroxide hybrids with potential for biofilm control. Verderosa AD, de la Fuente-Nunez C, Mansour SC, Cao J, Lu TK, Hancock REW, Fairfull-Smith KE. Eur J Med Chem. pubmed:28709125; doi:10.1016/j.ejmech.2017.06.058
20. Next-generation precision antimicrobials: towards personalized treatment of infectious diseases. de la Fuente-Nunez C, Torres MD, Mojica FJ, Lu TK. Curr Opin Microbiol. pubmed:28623720; doi:10.1016/j.mib.2017.05.014
21. Delivery technologies for genome editing. Yin H, Kauffman KJ, Anderson DG. Nat Rev Drug Discov. pubmed:28337020; doi:10.1038/nrd.2016.280
22. Protein Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh JN, Ardissino D, Gabriel SB, Willer CJ, Abecasis G, Saleheen D, Kubo M, Kato N, Chen YI, Dewey F, Kathiresan S. Circ Res. pubmed:28506971; doi:10.1161/CIRCRESAHA.117.311145
23. Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. Mitt M, Kals M, Parn K, Gabriel SB, Lander ES, Palotie A, Ripatti S, Morris AP, Metspalu A, Esko T, Magi R, Palta P. Eur J Hum Genet. pubmed:28401899; doi:10.1038/ejhg.2017.51
24. Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL. EMBO Rep. pubmed:28396572; doi:10.15252/embr.201643764
25. Noninvasive imaging of human immune responses in a human xenograft model of graft-versus-host disease. Van Elssen CH, Rashidian M, Vrbanac V, Wucherpfennig KW, El Habre Z, Sticht J, Freund C, Jacobsen J, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh H. J Nucl Med. pubmed:28209904; doi:10.2967/jnumed.116.186007
26. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, Gonzalez A, Ounzain S, Pedrazzini T. Sci Transl Med. pubmed:28637928; doi:10.1126/scitranslmed.aai9118
27. Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Rahman S, Magnussen M, Leon TE, Farah N, Li Z, Abraham BJ, Alapi KZ, Mitchell RJ, Naughton T, Fielding AK, Pizzey A, Bustraan S, Allen C, Popa T, Pike-Overzet K, Garcia-Perez L, Gale RE, Linch DC, Staal FJ, Young RA, Look AT, Mansour MR. Blood. pubmed:28270453; doi:10.1182/blood-2016-09-742148
28. The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans. Alvarez-Dominguez JR, Knoll M, Gromatzky AA, Lodish HF. Cell Rep. pubmed:28636939; doi:10.1016/j.celrep.2017.05.082
29. An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N. Cell Rep. pubmed:28658630; doi:10.1016/j.celrep.2017.06.016
30. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES. Cell. pubmed:28666119; doi:10.1016/j.cell.2017.06.011
31. IFNgamma-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Nirschl CJ, Suarez-Farinas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N. Cell. pubmed:28666115; doi:10.1016/j.cell.2017.06.016
32. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Santaguida S, Richardson A, Iyer DR, M'Saad O, Zasadil L, Knouse KA, Wong YL, Rhind N, Desai A, Amon A. Dev Cell. pubmed:28633018; doi:10.1016/j.devcel.2017.05.022
33. Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD. Immunity. pubmed:28636954; doi:10.1016/j.immuni.2017.06.005
34. Nature and Nurture: What Determines Tumor Metabolic Phenotypes?. Mayers JR, Vander Heiden MG. Cancer Res. pubmed:28584183; doi:10.1158/0008-5472.CAN-17-0165
35. Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation. Tech K, Tikunov AP, Farooq H, Morrissy AS, Meidinger J, Fish T, Green SC, Liu H, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Vander Heiden MG, Taylor MD, MacDonald J, Gershon TR. Cancer Res. pubmed:28515149; doi:10.1158/0008-5472.CAN-16-3304
36. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Nat Med. pubmed:28436957; doi:10.1038/nm.4328
37. Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells. Barriga FM, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X, Sevillano M, Guillaumet-Adkins A, Rodriguez-Esteban G, Buczacki SJ, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS, Gut I, Batlle E. Cell Stem Cell. pubmed:28285904; doi:10.1016/j.stem.2017.02.007
38. Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion. Turner CJ, Badu-Nkansah K, Hynes RO. Angiogenesis. pubmed:28667352; doi:10.1007/s10456-017-9563-8
39. Mechanisms of DNA damage, repair, and mutagenesis. Chatterjee N, Walker GC. Environ Mol Mutagen. pubmed:28485537; doi:10.1002/em.22087