The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: May 2016

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1. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A. ALTEX. pubmed:27180100;  doi:10.14573/altex.1603161

2. Microbiome therapeutics - Advances and challenges. Mimee M, Citorik RJ, Lu TK. Adv Drug Deliv Rev. pubmed:27158095;  doi:10.1016/j.addr.2016.04.032

3. Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design. Maass KF, Kulkarni C, Betts AM, Wittrup KD. AAPS J. pubmed:26912181;  doi:10.1208/s12248-016-9892-3

4. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y- or Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates. Cheal SM, Xu H, Guo HF, Lee SG, Punzalan B, Chalasani S, Fung EK, Jungbluth A, Zanzonico PB, Carrasquillo JA, O'Donoghue J, Smith-Jones PM, Wittrup KD, Cheung NV, Larson SM. Eur J Nucl Med Mol Imaging. pubmed:26596724;  doi:10.1007/s00259-015-3254-8

5. Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Tape CJ, Ling S, Dimitriadi M, McMahon KM, Worboys JD, Leong HS, Norrie IC, Miller CJ, Poulogiannis G, Lauffenburger DA, Jorgensen C. Cell. pubmed:27087446;  doi:10.1016/j.cell.2016.03.029

6. Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel. Archary D, Seaton KE, Passmore JS, Werner L, Deal A, Dunphy LJ, Arnold KB, Yates NL, Lauffenburger DA, Bergin P, Liebenberg LJ, Samsunder N, Mureithi MW, Altfeld M, Garrett N, Abdool Karim Q, Abdool Karim S, Morris L, Tomaras GD. Mucosal Immunol. pubmed:26813340;  doi:10.1038/mi.2015.145

7. Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection. Masson L, Arnold KB, Little F, Mlisana K, Lewis DA, Mkhize N, Gamieldien H, Ngcapu S, Johnson L, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS. Sex Transm Infect. pubmed:26511781;  doi:10.1136/sextrans-2015-052072

8. Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer. Dang X, Gu L, Qi J, Correa S, Zhang G, Belcher AM, Hammond PT. Proc Natl Acad Sci U S A. pubmed:27114520;  doi:10.1073/pnas.1521175113

9. An elastic second skin. Yu B, Kang SY, Akthakul A, Ramadurai N, Pilkenton M, Patel A, Nashat A, Anderson DG, Sakamoto FH, Gilchrest BA, Anderson RR, Langer R. Nat Mater. pubmed:27159017;  doi:10.1038/nmat4635

10. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles. Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. Proc Natl Acad Sci U S A. pubmed:27140638;  doi:10.1073/pnas.1603840113

11. mRNA vaccine delivery using lipid nanoparticles. Reichmuth AM, Oberli MA, Jeklenec A, Langer R, Blankschtein D. Ther Deliv. pubmed:27075952;  doi:10.4155/tde-2016-0006

12. A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention. Lee YL, Zhang S, Lin J, Langer R, Traverso G. Adv Healthc Mater. pubmed:27060695;  doi:10.1002/adhm.201501036

13. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression. Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB. Cancer Discov. pubmed:26811325;  doi:10.1158/2159-8290.CD-15-1183

14. Deformability-based cell selection with downstream immunofluorescence analysis. Shaw Bagnall J, Byun S, Miyamoto DT, Kang JH, Maheswaran S, Stott SL, Toner M, Manalis SR. Integr Biol (Camb). pubmed:26999591;  doi:10.1039/c5ib00284b

15. Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi). Cleto S, Jensen JV, Wendisch VF, Lu TK. ACS Synth Biol. pubmed:26829286;  doi:10.1021/acssynbio.5b00216

16. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlof O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, Sjogren M, Ngwa J, Brandimarto J, Stott DJ, Aguilar D, Rice KM, Sesso HD, Demissie S, Buckley BM, Taylor KD, Ford I, Yao C, Liu C, Sotoodehnia N, van der Harst P, Stricker BH, Kritchevsky SB, Liu Y, Gaziano JM, Hofman A, Moravec CS, Uitterlinden AG, Kellis M, van Meurs JB, Margulies KB, Dehghan A, Levy D, Olde B, Psaty BM, Cupples LA, Jukema JW, Djousse L, Franco OH, Boerwinkle E, Boyer LA, Newton-Cheh C, Butler J, Vasan RS, Cappola TP, Smith NL. PLoS Genet. pubmed:27149122;  doi:10.1371/journal.pgen.1006034

17. Induced Pluripotent Stem Cells Meet Genome Editing. Hockemeyer D, Jaenisch R. Cell Stem Cell. pubmed:27152442;  doi:10.1016/j.stem.2016.04.013

18. The history of the Y chromosome in man. Hughes JF, Page DC. Nat Genet. pubmed:27230683;  doi:10.1038/ng.3580

19. A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends. Kern DM, Nicholls PK, Page DC, Cheeseman IM. J Cell Biol. pubmed:27138257;  doi:10.1083/jcb.201510117

20. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL. PLoS Genet. pubmed:27138431;  doi:10.1371/journal.pgen.1006023

21. Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC. Proc Natl Acad Sci U S A. pubmed:27091975;  doi:10.1073/pnas.1604268113

22. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. J Exp Med. pubmed:27069117;  doi:10.1084/jem.20151790

23. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Nat Struct Mol Biol. pubmed:27043298;  doi:10.1038/nsmb.3199

24. Parkinson-associated risk variant in distal enhancer of alpha-synuclein modulates target gene expression. Soldner F, Stelzer Y, Shivalila CS, Abraham BJ, Latourelle JC, Barrasa MI, Goldmann J, Myers RH, Young RA, Jaenisch R. Nature. pubmed:27096366;  doi:10.1038/nature17939

25. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P. Cell. pubmed:27153497;  doi:10.1016/j.cell.2016.04.039

26. Luminidependens (LD) is an Arabidopsis protein with prion behavior. Chakrabortee S, Kayatekin C, Newby GA, Mendillo ML, Lancaster A, Lindquist S. Proc Natl Acad Sci U S A. pubmed:27114519;  doi:10.1073/pnas.1604478113

27. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG. Genes Dev. pubmed:27125672;  doi:10.1101/gad.278549.116

28. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Cell Stem Cell. pubmed:27184401;  doi:10.1016/j.stem.2016.04.002

29. Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin. Riddell IA, Johnstone TC, Park GY, Lippard SJ. Chemistry. pubmed:27111128;  doi:10.1002/chem.201600236

30. Membrane-permeable Mn(III) complexes for molecular MRI of intracellular targets. Barandov A, Bartelle BB, Gonzalez BA, White WL, Lippard SJ, Jasanoff A. J Am Chem Soc. pubmed:27088782;  doi:10.1021/jacs.5b13337

31. Elucidation of the roles of tumor integrin ss1 in the extravasation stage of the metastasis cascade. Chen MB, Lamar JM, Li R, Hynes RO, Kamm RD. Cancer Res. pubmed:26988988;  doi:10.1158/0008-5472.CAN-15-1325

32. A split horseradish peroxidase for the detection of intercellular protein-protein interactions and sensitive visualization of synapses. Martell JD, Yamagata M, Deerinck TJ, Phan S, Kwa CG, Ellisman MH, Sanes JR, Ting AY. Nat Biotechnol. pubmed:27240195;  doi:10.1038/nbt.3563

33. APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest. Lee SY, Kang MG, Park JS, Lee G, Ting AY, Rhee HW. Cell Rep. pubmed:27184847;  doi:10.1016/j.celrep.2016.04.064