The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: February 2016

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1. Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression. Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, Ishikawa K, Chen J, Hajjar RJ, Anderson DG, Costa KD. Mol Ther. pubmed:26471463;  doi:10.1038/mt.2015.193

2. Treatment with chondroitin sulfate to modulate inflammation and atherogenesis in obesity. Melgar-Lesmes P, Garcia-Polite F, Del-Rey-Puech P, Rosas E, Dreyfuss JL, Montell E, Verges J, Edelman ER, Balcells M. Atherosclerosis. pubmed:26714044;  doi:10.1016/j.atherosclerosis.2015.12.016

3. Structural Mechanics Predictions Relating to Clinical Coronary Stent Fracture in a 5 Year Period in FDA MAUDE Database. Everett KD, Conway C, Desany GJ, Baker BL, Choi G, Taylor CA, Edelman ER. Ann Biomed Eng. pubmed:26467552;  doi:10.1007/s10439-015-1476-3

4. Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating. Artzi N, Tzafriri AR, Faucher KM, Moodie G, Albergo T, Conroy S, Corbeil S, Martakos P, Virmani R, Edelman ER. Ann Biomed Eng. pubmed:26314990;  doi:10.1007/s10439-015-1435-z

5. Highly scalable, closed-loop synthesis of drug-loaded, layer-by-layer nanoparticles. Correa S, Choi KY, Dreaden EC, Renggli K, Shi A, Gu L, Shopsowitz KE, Quadir MA, Ben-Akiva E, Hammond PT. Adv Funct Mater. pubmed:27134622;  doi:10.1002/adfm.201504385

6. Three-dimensional multilayered fibrous constructs for wound healing applications. Reis TC, Castleberry S, Rego AM, Aguiar-Ricardo A, Hammond PT. Biomater Sci. pubmed:26584183;  doi:10.1039/c5bm00211g

7. Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA delivery in vivo. Dong Y, Dorkin JR, Wang W, Chang PH, Webber MJ, Tang BC, Yang J, Abutbul-Ionita I, Danino D, DeRosa F, Heartlein M, Langer R, Anderson DG. Nano Lett. pubmed:26727632;  doi:10.1021/acs.nanolett.5b02428

8. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. J Cell Biol. pubmed:26880201;  doi:10.1083/jcb.201506118

9. Advances in discovering small molecules to probe protein function in a systems context. Doyle SK, Pop MS, Evans HL, Koehler AN. Curr Opin Chem Biol. pubmed:26615565;  doi:10.1016/j.cbpa.2015.10.032

10. Controlling and predicting droplet size of nanoemulsions: scaling relations with experimental validation. Gupta A, Eral HB, Hatton TA, Doyle PS. Soft Matter. pubmed:26646895;  doi:10.1039/c5sm02051d

11. Foundations and Emerging Paradigms for Computing in Living Cells. Ma KC, Perli SD, Lu TK. J Mol Biol. pubmed:26908220;  doi:10.1016/j.jmb.2016.02.018

12. The era of synthetic biology and genome engineering: Where no man has gone before. Lu TK, Chandrasegaran S, Hodak H. J Mol Biol. pubmed:26827726;  doi:10.1016/j.jmb.2016.01.025

13. Comparison of the Absorbable Polymer Sirolimus-Eluting Stent (MiStent) to the Durable Polymer Everolimus-Eluting Stent (Xience) (from the DESSOLVE I/II and ISAR-TEST-4 Studies). Lansky AJ, Kastrati A, Edelman ER, Parise H, Ng VG, Ormiston J, Wijns W, Byrne RA. Am J Cardiol. pubmed:26762729;  doi:10.1016/j.amjcard.2015.11.044

14. Enhanced energy transport in genetically engineered excitonic networks. Park H, Heldman N, Rebentrost P, Abbondanza L, Iagatti A, Alessi A, Patrizi B, Salvalaggio M, Bussotti L, Mohseni M, Caruso F, Johnsen HC, Fusco R, Foggi P, Scudo PF, Lloyd S, Belcher AM. Nat Mater. pubmed:26461447;  doi:10.1038/nmat4448

15. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, Shamji AF, Koehler AN, Schenone M, Burgin AB, Schreiber SL, Greulich H, Meyerson M. Nat Chem Biol. pubmed:26656089;  doi:10.1038/nchembio.1984

16. Single-Cell Detection of Secreted Abeta and sAPPalpha from Human IPSC-Derived Neurons and Astrocytes. Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, Love JC, Young-Pearse TL. J Neurosci. pubmed:26843653;  doi:10.1523/JNEUROSCI.2735-15.2016

17. A Receptor for All Occasions. Irvine DJ. Cell. pubmed:26871625;  doi:10.1016/j.cell.2016.01.030

18. Shooting for the Moon: Nanoscale Approaches to Cancer. Hammond PT. ACS Nano. pubmed:26902596;  doi:10.1021/acsnano.6b01095

19. Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep. Zani BG, Baird R, Stanley JR, Markham PM, Wilke M, Zeiter S, Beck A, Nehrbass D, Kopia GA, Edelman ER, Rabiner R. J Biomed Mater Res B Appl Biomater. pubmed:25772144;  doi:10.1002/jbm.b.33380

20. Implantation of healthy matrix-embedded endothelial cells rescues dysfunctional endothelium and ischaemic tissue in liver engraftment. Melgar-Lesmes P, Balcells M, Edelman ER. Gut. pubmed:26851165;  doi:10.1136/gutjnl-2015-310409

21. Structurally Defined alphaMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Fang T, Duarte JN, Ling J, Li Z, Guzman JS, Ploegh HL. Angew Chem Int Ed Engl. pubmed:26840214;  doi:10.1002/anie.201509432

22. 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA. Cell Stem Cell. pubmed:26686465;  doi:10.1016/j.stem.2015.11.007

23. Tet1 and Tet2 protect DNA methylation canyons against hypermethylation. Wiehle L, Raddatz G, Musch T, Dawlaty MM, Jaenisch R, Lyko F, Breiling A. Mol Cell Biol. pubmed:26598602;  doi:10.1128/MCB.00587-15

24. Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos. Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R. Proc Natl Acad Sci U S A. pubmed:26811475;  doi:10.1073/pnas.1525518113

25. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S. Proc Natl Acad Sci U S A. pubmed:26811477;  doi:10.1073/pnas.1521763113

26. H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs. Surface LE, Fields PA, Subramanian V, Behmer R, Udeshi N, Peach SE, Carr SA, Jaffe JD, Boyer LA. Cell Rep. pubmed:26804911;  doi:10.1016/j.celrep.2015.12.100

27. Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assuncao JA, Bodor C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. Nat Genet. pubmed:26691987;  doi:10.1038/ng.3473

28. Stromal expression of miR-143/145 promotes neoangiogenesis in lung cancer development. Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong RM, Miller KM, Bendor J, Jacks T. Cancer Discov. pubmed:26586766;  doi:10.1158/2159-8290.CD-15-0854

29. Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity. Caron A, Labbe SM, Lanfray D, Blanchard PG, Villot R, Roy C, Sabatini DM, Richard D, Laplante M. Mol Metab. pubmed:26909318;  doi:10.1016/j.molmet.2015.11.005

30. EGLN1 Inhibition and Rerouting of alpha-Ketoglutarate Suffice for Remote Ischemic Protection. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WGJr. Cell. pubmed:26919427;  doi:10.1016/j.cell.2016.02.006

31. Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ. Immunity. pubmed:26872698;  doi:10.1016/j.immuni.2015.11.024

32. Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes. Boodram JN, Mcgregor IJ, Bruno PM, Cressey PB, Hemann MT, Suntharalingam K. Angew Chem Int Ed Engl. pubmed:26806362;  doi:10.1002/anie.201510443

33. Achieving Reversible Sensing of Nitroxyl (HNO) by Tuning the Ligand Environment of Azamacrocyclic Copper(II) Com-plexes. Kim S, Minier MA, Loas A, Becker S, Wang F, Lippard SJ. J Am Chem Soc. pubmed:26836121;  doi:10.1021/jacs.5b12825

34. A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells. Patra M, Johnstone TC, Suntharalingam K, Lippard SJ. Angew Chem Int Ed Engl. pubmed:26749149;  doi:10.1002/anie.201510551

35. Non Mutagenic and Mutagenic DNA Damage Tolerance. D'Souza S, Yamanaka K, Walker GC. Cell Cycle. pubmed:26727652;  doi:10.1080/15384101.2015.1132909