The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: September 2015

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1. Vascular Dilation, Tachycardia, and Increased Inotropy Occur Sequentially with Increasing Epinephrine Dose Rate, Plasma and Myocardial Concentrations, and cAMP. Maslov MY, Wei AE, Pezone MJ, Edelman ER, Lovich MA. Heart Lung Circ. pubmed:25790776;  doi:10.1016/j.hlc.2015.02.012

2. Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides. Hsu BB, Conway W, Tschabrunn CM, Mehta M, Perez-Cuevas M, Zhang S, Hammond PT. ACS Nano. pubmed:26284753;  doi:10.1021/acsnano.5b02374

3. Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning. Ozkumur AY, Goods BA, Love JC. Small. pubmed:26121321;  doi:10.1002/smll.201500674

4. A broadly neutralizing human monoclonal antibody is effective against H7N9. Tharakaraman K, Subramanian V, Viswanathan K, Sloan S, Yen HL, Barnard DL, Leung YH, Szretter KJ, Koch TJ, Delaney JC, Babcock GJ, Wogan GN, Sasisekharan R, Shriver Z. Proc Natl Acad Sci U S A. pubmed:26283346;  doi:10.1073/pnas.1502374112

5. Celebrating Soft Matter's 10th Anniversary: Sequential phase transitions in thermoresponsive nanoemulsions. Hsiao LC, Doyle PS. Soft Matter. pubmed:26367251;  doi:10.1039/c5sm01581b

6. Miniaturized, biopsy-implantable chemical sensor with wireless, magnetic resonance readout. Vassiliou CC, Liu VH, Cima MJ. Lab Chip. pubmed:26177607;  doi:10.1039/c5lc00546a

7. Paired exome analysis of Barrett's esophagus and adenocarcinoma. Stachler MD, Taylor-Weiner A, Peng S, McKenna A, Agoston AT, Odze RD, Davison JM, Nason KS, Loda M, Leshchiner I, Stewart C, Stojanov P, Seepo S, Lawrence MS, Ferrer-Torres D, Lin J, Chang AC, Gabriel SB, Lander ES, Beer DG, Getz G, Carter SL, Bass AJ. Nat Genet. pubmed:26192918;  doi:10.1038/ng.3343

8. Allosteric activation of apicomplexan calcium-dependent protein kinases. Ingram JR, Knockenhauer KE, Markus BM, Mandelbaum J, Ramek A, Shan Y, Shaw DE, Schwartz TU, Ploegh HL, Lourido S. Proc Natl Acad Sci U S A. pubmed:26305940;  doi:10.1073/pnas.1505914112

9. Hallmarks of pluripotency. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Nature. pubmed:26399828;  doi:10.1038/nature15515

10. Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution. Stelzer Y, Shivalila CS, Soldner F, Markoulaki S, Jaenisch R. Cell. pubmed:26406378;  doi:10.1016/j.cell.2015.08.046

11. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, Stover DG, Lim E, Wang ZC, Iglehart JD, Young RA, Gray NS, Zhao JJ. Cell. pubmed:26406377;  doi:10.1016/j.cell.2015.08.063

12. A conversation with Rudolf Jaenisch. Jaenisch R, Neill US. J Clin Invest. pubmed:26325030;  doi:10.1172/JCI82629

13. Failure to replicate the STAP cell phenomenon. De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ. Nature. pubmed:26399835;  doi:10.1038/nature15513

14. A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary. Soh YQ, Junker JP, Gill ME, Mueller JL, van Oudenaarden A, Page DC. PLoS Genet. pubmed:26378784;  doi:10.1371/journal.pgen.1005531

15. TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ. EMBO Mol Med. pubmed:26136358;  doi:10.15252/emmm.201404967

16. Proceedings from the Turner Resource Network symposium: The crossroads of health care research and health care delivery. Backeljauw PF, Bondy C, Chernausek SD, Cernich JT, Cole DA, Fasciano LP, Foodim J, Hawley S, Hong DS, Knickmeyer RC, Kruszka P, Lin AE, Lippe BM, Lorigan GA, Maslen CL, Mauras N, Page DC, Pemberton VL, Prakash SK, Quigley CA, Ranallo KC, Reiss AL, Sandberg DE, Scurlock C, Silberbach M. Am J Med Genet A. pubmed:25920614;  doi:10.1002/ajmg.a.37121

17. Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments. Li Z, Theile CS, Chen GY, Bilate AM, Duarte JN, Avalos AM, Fang T, Barberena R, Sato S, Ploegh HL. Angew Chem Int Ed Engl. pubmed:26252716;  doi:10.1002/anie.201505277

18. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM. Cell Rep. pubmed:26299971;  doi:10.1016/j.celrep.2015.07.052

19. Lack of Evidence for PKM2 Protein Kinase Activity. Hosios AM, Fiske BP, Gui DY, Vander Heiden MG. Mol Cell. pubmed:26300261;  doi:10.1016/j.molcel.2015.07.013

20. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Nicolay BN, Danielian PS, Kottakis F, Lapek JDJr, Sanidas I, Miles WO, Dehnad M, Tschop K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. Genes Dev. pubmed:26314710;  doi:10.1101/gad.264127.115

21. Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T. Genes Dev. pubmed:26341558;  doi:10.1101/gad.267393.115

22. Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. Joshi NS, Akama-Garren EH, Lu Y, Lee DY, Chang GP, Li A, DuPage M, Tammela T, Kerper NR, Farago AF, Robbins R, Crowley DM, Bronson RT, Jacks T. Immunity. pubmed:26341400;  doi:10.1016/j.immuni.2015.08.006

23. Coupling Oxygen Consumption with Hydrocarbon Oxidation in Bacterial Multicomponent Monooxygenases. Wang W, Liang AD, Lippard SJ. Acc Chem Res. pubmed:26293615;  doi:10.1021/acs.accounts.5b00312

24. Tonic Zinc Inhibits Spontaneous Neuronal Firing in Dorsal Cochlear Nucleus Principal Neurons by Enhancing Glycinergic Neurotransmission. Perez-Rosello T, Anderson CT, Ling C, Lippard SJ, Tzounopoulos T. Neurobiol Dis. pubmed:25796568;  doi:10.1016/j.nbd.2015.03.012

25. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. J Biomol Screen. pubmed:25918037;  doi:10.1177/1087057115583037

26. Lamellipodin is Important for Cell to Cell Spread and Actin-based Motility in Listeria monocytogenes. Wang J, King JE, Goldrick M, Lowe M, Gertler FB, Roberts IS. Infect Immun. pubmed:26169271;  doi:10.1128/IAI.00193-15

27. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Ye X, Tam WL, Shibue T, Kaygusuz Y, Reinhardt F, Ng Eaton E, Weinberg RA. Nature. pubmed:26331542;  doi:10.1038/nature14897

28. Vasodilator-stimulated phosphoprotein (VASP) restricts cell-to-cell spread of Shigella flexneri at the cell periphery. Lee SY, Gertler FB, Goldberg MB. Microbiology. pubmed:26358985;  doi:10.1099/mic.0.000173

29. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, Hu Y, Udeshi ND, Lau TY, Wirtz-Peitz F, He L, Ting AY, Carr SA, Perrimon N. Proc Natl Acad Sci U S A. pubmed:26362788;  doi:10.1073/pnas.1515623112