The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: August 2015

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1. Non-genetic engineering of cells for drug delivery and cell-based therapy. Wang Q, Cheng H, Peng H, Zhou H, Li PY, Langer R. Adv Drug Deliv Rev. pubmed:25543006;  doi:10.1016/j.addr.2014.12.003

2. Engineering New Approaches to Cancer Vaccines. Mehta NK, Moynihan KD, Irvine DJ. Cancer Immunol Res. pubmed:26156157;  doi:10.1158/2326-6066.CIR-15-0112

3. A Novel Algorithm to Quantify Coronary Remodeling Using Inferred Normal Dimensions. Falcao BA, Falcao JL, Morais GR, Silva RC, Lopes AC, Soares PR, Mariani JJr, Kalil-Filho R, Edelman ER, Lemos PA. Arq Bras Cardiol. pubmed:26291843;  doi:

4. Editorial overview: Special section: Immunological engineering. Irvine DJ, Ploegh H. Curr Opin Immunol. pubmed:26275317;  doi:10.1016/j.coi.2015.07.010

5. H nuclear magnetic resonance (NMR) as a tool to measure dehydration in mice. Li M, Vassiliou CC, Colucci LA, Cima MJ. NMR Biomed. pubmed:26123278;  doi:10.1002/nbm.3334

6. Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation. Antoniadis AP, Mortier P, Kassab G, Dubini G, Foin N, Murasato Y, Giannopoulos AA, Tu S, Iwasaki K, Hikichi Y, Migliavacca F, Chiastra C, Wentzel JJ, Gijsen F, Reiber JH, Barlis P, Serruys PW, Bhatt DL, Stankovic G, Edelman ER, Giannoglou GD, Louvard Y, Chatzizisis YS. JACC Cardiovasc Interv. pubmed:26315731;  doi:10.1016/j.jcin.2015.06.015

7. Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating. Artzi N, Tzafriri AR, Faucher KM, Moodie G, Albergo T, Conroy S, Corbeil S, Martakos P, Virmani R, Edelman ER. Ann Biomed Eng. pubmed:26314990;  doi:10.1007/s10439-015-1435-z

8. Covalent modification of synthetic hydrogels with bioactive proteins via sortase-mediated ligation. Cambria E, Renggli K, Ahrens CC, Cook CD, Kroll C, Krueger AT, Imperiali B, Griffith LG. Biomacromolecules. pubmed:26098148;  doi:10.1021/acs.biomac.5b00549

9. Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo. Almquist BD, Castleberry SA, Sun JB, Lu AY, Hammond PT. Adv Healthc Mater. pubmed:26270898;  doi:10.1002/adhm.201500403

10. Influence of pH and Surface Chemistry on Poly-L-Lysine Adsorption onto Solid Supports Investigated by Quartz Crystal Microbalance with Dissipation Monitoring. Choi JH, Kim SO, Linardy E, Dreaden EC, Zhdanov VP, Hammond PT, Cho NJ. J Phys Chem B. pubmed:26061703;  doi:10.1021/acs.jpcb.5b01553

11. An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease. Zhang S, Ermann J, Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G, Langer R, Karp JM. Sci Transl Med. pubmed:26268315;  doi:10.1126/scitranslmed.aaa5657

12. Nanomedicines Targeting the Tumor Microenvironment. Tong R, Langer R. Cancer J. pubmed:26222084;  doi:10.1097/PPO.0000000000000123

13. Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules. O'Shea TM, Webber MJ, Aimetti AA, Langer R. Adv Healthc Mater. pubmed:26088467;  doi:10.1002/adhm.201500334

14. A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays. Patel AK, Celiz AD, Rajamohan D, Anderson DG, Langer R, Davies MC, Alexander MR, Denning C. Biomaterials. pubmed:26005764;  doi:10.1016/j.biomaterials.2015.05.019

15. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Cell Metab. pubmed:26244933;  doi:10.1016/j.cmet.2015.07.015

16. Isocost Lines Describe the Cellular Economy of Genetic Circuits. Gyorgy A, Jimenez JI, Yazbek J, Huang HH, Chung H, Weiss R, Del Vecchio D. Biophys J. pubmed:26244745;  doi:10.1016/j.bpj.2015.06.034

17. Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery. Wroblewska L, Kitada T, Endo K, Siciliano V, Stillo B, Saito H, Weiss R. Nat Biotechnol. pubmed:26237515;  doi:10.1038/nbt.3301

18. Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates. Chen L, An HZ, Doyle PS. Langmuir. pubmed:26244815;  doi:10.1021/acs.langmuir.5b02200

19. Minor changes in expression of the mismatch repair protein MSH2 exert a major impact on glioblastoma response to temozolomide. McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Cancer Res. pubmed:26025730;  doi:10.1158/0008-5472.CAN-14-3616

20. Endothelial thermotolerance impairs nanoparticle transport in tumors. Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN. Cancer Res. pubmed:26122846;  doi:10.1158/0008-5472.CAN-15-0325

21. Diabetes: A smart insulin patch. Veiseh O, Langer R. Nature. pubmed:26245577;  doi:10.1038/524039a

22. Synthetic communities, the sum of parts. Teague BP, Weiss R. Science. pubmed:26315419;  doi:10.1126/science.aad0876

23. Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells. Li Y, Shen C, Zhu B, Shi F, Eisen HN, Chen J. J Immunol. pubmed:26163589;  doi:10.4049/jimmunol.1500451

24. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dancik V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ. Proc Natl Acad Sci U S A. pubmed:26195741;  doi:10.1073/pnas.1512289112

25. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, Folarin OA, Goba A, Odia I, Ehiane PE, Momoh M, England EM, Winnicki S, Branco LM, Gire SK, Phelan E, Tariyal R, Tewhey R, Omoniwa O, Fullah M, Fonnie R, Fonnie M, Kanneh L, Jalloh S, Gbakie M, Saffa S, Karbo K, Gladden AD, Qu J, Stremlau M, Nekoui M, Finucane HK, Tabrizi S, Vitti JJ, Birren B, Fitzgerald M, McCowan C, Ireland A, Berlin AM, Bochicchio J, Tazon-Vega B, Lennon NJ, Ryan EM, Bjornson Z, Milner DAJr, Lukens AK, Broodie N, Rowland M, Heinrich M, Akdag M, Schieffelin JS, Levy D, Akpan H, Bausch DG, Rubins K, McCormick JB, Lander ES, Gunther S, Hensley L, Okogbenin S, Schaffner SF, Okokhere PO, Khan SH, Grant DS, Akpede GO, Asogun DA, Gnirke A, Levin JZ, Happi CT, Garry RF, Sabeti PC. Cell. pubmed:26276630;  doi:10.1016/j.cell.2015.07.020

26. Association between very small tumor size and increased cancer-specific mortality following radical prostatectomy in node-positive prostate cancer. Muralidhar V, Mahal BA, Nezolosky MD, Beard CJ, Feng FY, Martin NE, Efstathiou JA, Choueiri TK, Pomerantz MM, Sweeney CJ, Trinh QD, Vander Heiden MG, Nguyen PL. BJU Int. pubmed:26235660;  doi:10.1111/bju.13248

27. A roadmap for interpreting C metabolite labeling patterns from cells. Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Noh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. Curr Opin Biotechnol. pubmed:25731751;  doi:10.1016/j.copbio.2015.02.003

28. Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein. Nordman JT, Orr-Weaver TL. Bioessays. pubmed:26059810;  doi:10.1002/bies.201500021

29. Short- and long-term effects of chromosome mis-segregation and aneuploidy. Santaguida S, Amon A. Nat Rev Mol Cell Biol. pubmed:26204159;  doi:10.1038/nrm4025

30. Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C elegans. Bhatla N, Droste R, Sando SR, Huang A, Horvitz HR. Curr Biol. pubmed:26212880;  doi:10.1016/j.cub.2015.06.052

31. Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM. Dis Model Mech. pubmed:26044958;  doi:10.1242/dmm.019059

32. Single Turnover Reveals Oxygenated Intermediates in Toluene/o-Xylene Monooxygenase in the Presence of the Native Redox Partners. Liang AD, Lippard SJ. J Am Chem Soc. pubmed:26267757;  doi:10.1021/jacs.5b07055

33. Singlet-Triplet Gaps of Cobalt Nitrosyls: Insights from Tropocoronand Complexes. Hopmann KH, Conradie J, Tangen E, Tonzetich ZJ, Lippard SJ, Ghosh A. Inorg Chem. pubmed:26203786;  doi:10.1021/acs.inorgchem.5b00901

34. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Hsu AT, Barrett CD, George DeBusk M, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB. Shock. pubmed:26009816;  doi:10.1097/SHK.0000000000000386

35. A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3zetazeta. Lee MS, Glassman CR, Deshpande NR, Badgandi HB, Parrish HL, Uttamapinant C, Stawski PS, Ting AY, Kuhns MS. Immunity. pubmed:26231119;  doi:10.1016/j.immuni.2015.06.018