The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: July 2015

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Publications Citing Koch Institute Faculty Members

1. Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term. Bajpayee AG, Quadir MA, Hammond PT, Grodzinsky AJ. Osteoarthritis Cartilage. pubmed:26211608;  doi:10.1016/j.joca.2015.07.010

2. Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers. Tian F, Min J, Kanka J, Li X, Hammond PT, Du H. Opt Express. pubmed:26367671;  

3. Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes. Atukorale PU, Yang YS, Bekdemir A, Carney RP, Silva PJ, Watson N, Stellacci F, Irvine DJ. Nanoscale. pubmed:26077112;  doi:10.1039/c5nr01355k

4. Accelerating the Translation of Nanomaterials in Biomedicine. Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C. ACS Nano. pubmed:26115196;  doi:10.1021/acsnano.5b03569

5. Adenovirus-mediated somatic genome editing of Pten by CRISPR/Cas9 in mouse liver in spite of Cas9-specific immune responses. Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer E, Weng Z, Gao G, Xue W. Hum Gene Ther. pubmed:26086867;  doi:10.1089/hum.2015.087

6. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA. Sci Transl Med. pubmed:26180101;  doi:10.1126/scitranslmed.aaa6645

7. Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Celiz AD, Smith JG, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR. Adv Mater. pubmed:26033422;  doi:10.1002/adma.201501351

8. A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production. Mozdzierz NJ, Love KR, Lee KS, Lee HL, Shah KA, Ram RJ, Love JC. Lab Chip. pubmed:26055071;  doi:10.1039/c5lc00443h

9. Photopatterned oil-reservoir micromodels with tailored wetting properties. Lee H, Lee SG, Doyle PS. Lab Chip. pubmed:26082065;  doi:10.1039/c5lc00277j

10. Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor. Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR. Drug Metab Dispos. pubmed:25926431;  doi:10.1124/dmd.115.063495

11. Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. Patil SU, Ogunniyi AO, Calatroni A, Tadigotla VR, Ruiter B, Ma A, Moon J, Love JC, Shreffler WG. J Allergy Clin Immunol. pubmed:25985925;  doi:10.1016/j.jaci.2015.03.026

12. Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope. Robinson LN, Tharakaraman K, Rowley KJ, Costa VV, Chan KR, Wong YH, Ong LC, Tan HC, Koch T, Cain D, Kirloskar R, Viswanathan K, Liew CW, Tissire H, Ramakrishnan B, Myette JR, Babcock GJ, Sasisekharan V, Alonso S, Chen J, Lescar J, Shriver Z, Ooi EE, Sasisekharan R. Cell. pubmed:26189681;  doi:10.1016/j.cell.2015.06.057

13. The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Meyer AS, Zweemer AJ, Lauffenburger DA. Cell Syst. pubmed:26236777;  doi:10.1016/j.cels.2015.06.002

14. Quantitative visualization of alternative exon expression from RNA-seq data. Katz Y, Wang ET, Silterra J, Schwartz S, Wong B, Thorvaldsdottir H, Robinson JT, Mesirov JP, Airoldi EM, Burge CB. Bioinformatics. pubmed:25617416;  doi:10.1093/bioinformatics/btv034

15. Brave New Genome. Lander ES. N Engl J Med. pubmed:26039524;  doi:10.1056/NEJMp1506446

16. Lncing Epigenetic Control of Transcription to Cardiovascular Development and Disease. Rizki G, Boyer LA. Circ Res. pubmed:26139858;  doi:10.1161/CIRCRESAHA.117.304156

17. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cacchiarelli D, Trapnell C, Ziller MJ, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, Rinn JL, Daley GQ, Meissner A, Lander ES, Mikkelsen TS. Cell. pubmed:26186193;  doi:10.1016/j.cell.2015.06.016

18. Pyruvate kinase: Function, regulation and role in cancer. Israelsen WJ, Vander Heiden MG. Semin Cell Dev Biol. pubmed:26277545;  doi:10.1016/j.semcdb.2015.08.004

19. Nontoxic antimicrobials that evade drug resistance. Davis SA, Vincent BM, Endo MM, Whitesell L, Marchillo K, Andes DR, Lindquist S, Burke MD. Nat Chem Biol. pubmed:26030729;  doi:10.1038/nchembio.1821

20. Applications of the CRISPR-Cas9 system in cancer biology. Sanchez-Rivera FJ, Jacks T. Nat Rev Cancer. pubmed:26040603;  doi:10.1038/nrc3950

21. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. Cell. pubmed:26232224;  doi:10.1016/j.cell.2015.07.016

22. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Cell. pubmed:26232225;  doi:10.1016/j.cell.2015.07.017

23. The Extracellular Matrix: Tools and Insights for the "Omics" Era. Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes RO. Matrix Biol. pubmed:26163349;  doi:10.1016/j.matbio.2015.06.003